Investigation of some pathophysiological effects of prolonged hypocalcaemia in sheep induced by infusing Na2EDTA solution for 4 hours daily on three consecutive days

Fenwick, D. C.; Daniel, R.C.W.

doi:10.1016/0007-1935(92)90083-d

Cited by 5 publications

(2 citation statements)

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“…This may be caused by phosphorus loss in colostrum, inadequate phosphorus intake around parturition, inadequate phosphorus mobilization from bone, and/or phosphorus diuresis caused by the high blood concentrations of parathyroid hormone (PTH) due to hypocalcemia [17]. In the present study, the plasma P concentrations significantly decreased followed by a reduction in the Ca concentrations during Ca-free HD, which was the same result as in previous studies on experimental hypocalcemia induced by Na 2 EDTA infusion in cows and sheep [3,9,18,19,22]. In experimental hypocalcemia, it is suggested that the hypophosphatemia is due to PTH action.…”

Section: Discussionsupporting

confidence: 89%

“…The clinical signs observed during hemodialysis were mobility, demeanor, shivering, ruminal motility and heart sound quality by auscultation. Blood There are numerous reports dealing with an experimentally induced hypocalcemia in ruminants as a model for studies of the pathophysiology and prophylaxis of milk fever (parturient paresis, parturient hypocalcemia) [3,8,9,12,13,18,19,22]. Most of the reports have described an intravenous infusion of disodium ethylenediaminetetraacetic acid (Na 2 EDTA) solution to induce experimental hypocalcemia.…”

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confidence: 99%

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Experimental Hypocalcemia Induced by Hemodialysis in Goats.

Yamagishi

Oishi

Sato

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. To evaluate whether hemodialysis with a dialysate containing no calcium (Ca-free HD) can induce hypocalcemia and restore the clinical signs and blood biochemical changes in naturally occurred hypocalcemic disorder in ruminants, the clinical signs and the changes in plasma electrolytes and minerals concentrations were observed in goats during 6-hr hemodialysis. The four goats received hemodialysis with the dialysate containing calcium (Ca HD), and 10 days later they had Ca-free HD. The plasma ionized Ca (Ca ++ ) and total Ca (TCa) concentrations were not affected by Ca HD, whereas the levels significantly decreased during whole period of Ca-free HD. The Ca ++ and TCa concentrations were 0.69 ± 0.06 mmol/l and 5.9 ± 0.3 mg/dl at 6 hr of Ca-free HD, respectively. The clinical signs observed during Ca-free HD seemed to resemble to those in naturally occurred hypocalcemic cases that were reported previously. Therefore, Ca-free HD was suggested to be one of the possible methods to induce experimental hypocalcemia in ruminants.-KEY WORDS: experimental hypocalcemia, goat, hemodialysis, ruminant.

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