Investigation of the Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Stem Bark of Sonapatha<i>Oroxylum indicum In Vivo</i>

Lalrinzuali, Khawlhring; Vabeiryureilai, Mathipi; Jagetia, Ganesh Chandra

doi:10.1155/2016/8247014

Cited by 46 publications

(32 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural products are widely used in folk medicine to treat inflammatory conditions, including fever, pain, migraine and arthritis, being targets for the development of new anti-inflammatory drugs. 172 Studies with plant extracts have shown promissory activity. 173 H. isora root extract showed antinociceptive activity in mice.…”

Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 99%

Helicteres L. SPECIES (Malvaceae SENSU LATO) AS SOURCE OF NEW DRUGS: A REVIEW

Fernandes¹,

Assis²,

Souza³

et al. 2020

Quim. Nova

View full text Add to dashboard Cite

Helicteres genus, Malvaceae, has pantropical distribution, encompasses about 60 species, 31 of them found in Brazil. Species belonging to this genus are used for treatment of various diseases and aroused scientific interest in search for bioactive compounds present in these plants. In this context, this review aims to provide a complete and concise overview of scientific advances in phytochemical and pharmacological studies of these species and their use by folk medicine. The presented data were collected from scientific databases, 'Web of Science', 'Scifinder', 'Pubmed', 'Sciencedirect', and 'Google Scholar', using the keyword 'Helicteres'. The species H. isora and H. angustifolia, found in Asia, are the most explored scientifically, whereas studies of species of this genus found in Americas are still rare, being possible to highlight studies carried out in Brazil with H. velutina and H. eichleri. About 149 compounds were isolated and characterized in the genus, being emphasized terpenoids, flavonoids and lignoids. These species have demonstrated various pharmacological properties in vitro and in vivo, incluinding insecticide, antidiabetic, antitumor and hepatoprotective activities. The presented data show the importance of studies carried out isolating bioactive compounds from this genus that may be used in several diseases' treatment or/as prototypes to development of new drugs.

show abstract

Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 99%

Helicteres L. SPECIES (Malvaceae SENSU LATO) AS SOURCE OF NEW DRUGS: A REVIEW

Fernandes¹,

Assis²,

Souza³

et al. 2020

Quim. Nova

View full text Add to dashboard Cite

show abstract

“…A separate experiment was carried out to evaluate the anti-inflammatory activity by xylene-induced ear edema in mice model and the results are listed in Fig. 6 [27]. Although AMD3100 is the only well investigated small molecule CXCR4 antagonist, its bicyclam structure leads to toxicity in the animal model.…”

Section: Resultsmentioning

confidence: 99%

“…The difference in weight of the two ear plugs was taken as a measure of edematous response. The inflammation-suppression percentage was calculated by comparing the drug-treated group to the control group [27]. …”

Section: Methodsmentioning

confidence: 99%

Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library

Bai

Shi

Liang

et al. 2017

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

CXCR4 plays a crucial role in recruitment of inflammatory cells to inflammation sites at the beginning of the disease process. Modulating CXCR4 functions presents a new avenue for antiinflammatory strategies. However, using CXCR4 antagonists for a long term usage presents potential serious side effect due to their stem cell mobilizing property. We have been developing partial CXCR4 antagonists without such property. A new computer-aided drug design program, the FRESH workflow, was used for anti-CXCR4 lead compound discovery and optimization, which coupled both compound library building and CXCR4 docking screens in one campaign. Based on the designed parent framework, 30 prioritized amide-sulfamide structures were obtained after systemic filtering and docking screening. Twelve compounds were prepared from the top-30 list. Most synthesized compounds exhibited good to excellent binding affinity to CXCR4. Compounds Ig and Im demonstrated notable in vivo suppressive activity against xylene-induced mouse ear inflammation (with 56% and 54% inhibition). Western blot analyses revealed that Ig significantly blocked CXCR4/CXCL12-mediated phosphorylation of Akt. Moreover, Ig attenuated the amount of TNF-α secreted by pathogenic E. coli-infected macrophages. More importantly, Ig had no observable cytotoxicity. Our results demonstrated that FRESH virtual high throughput screening program of targeted chemical class could successfully find potent lead compounds, and

show abstract

“…To evaluate the in vivo anti-inflammatory activity of the amide-sulfamide compounds, we performed a xylene-induced ear edema experiment [23]. This xylene-induced ear edema model is widely used in the evaluation of inflammatory activity.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Novel anti-inflammatory agents targeting CXCR4: Design, synthesis, biological evaluation and preliminary pharmacokinetic study

Bai

Liang

Yoon

et al. 2017

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

CXCR4 plays a crucial role in the inflammatory disease process, providing an attractive means for drug targeting. A series of novel amide-sulfamide derivatives were designed, synthesized and comprehensively evaluated. This new scaffold exhibited much more potent CXCR4 inhibitory activity, with more than 70% of the compounds showed notably better binding affinity than the reference drug AMD3100 in the binding assay. Additionally, in the Matrigel invasion assay, most of our compounds significantly blocked the tumor cell invasion, demonstrating superior efficacy compared to AMD3100. Furthermore, compound IIj blocked mice ear inflammation by 75% and attenuated ear edema and damage substantially in an in vivo model of inflammation. Western blot analyses revealed that CXCR4 modulator IIj significantly blocked CXCR4/CXCL12-mediated phosphorylation of Akt. Moreover, compound IIj had no observable cytotoxicity and displayed a favourable plasma stability in our preliminary pharmacokinetic study. The preliminary structure-activity relationships were also summarized. In short, this novel amide-sulfamide scaffold exhibited potent CXCR4 inhibitory activity both in vitro and in vivo. These results also confirmed that developing modulators targeting CXCR4 provides an exciting avenue for treatment of inflammation.

show abstract

Investigation of the Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Stem Bark of SonapathaOroxylum indicum In Vivo

Cited by 46 publications

References 41 publications

Helicteres L. SPECIES (Malvaceae SENSU LATO) AS SOURCE OF NEW DRUGS: A REVIEW

Helicteres L. SPECIES (Malvaceae SENSU LATO) AS SOURCE OF NEW DRUGS: A REVIEW

Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library

Novel anti-inflammatory agents targeting CXCR4: Design, synthesis, biological evaluation and preliminary pharmacokinetic study

Contact Info

Product

Resources

About