Investigation of the effects of propofol/ketamine versus propofol/fentanyl on nausea- vomiting administered for sedation in children undergoing magnetic resonance imaging:  a prospective randomized double-blinded study

Gürcan, Haci Semih; Ülgey, Ayşe; Gergin, Özlem Öz; Pehlivan, Sibel Seçkin; Yildiz, Kara Mehmet

doi:10.3906/sag-2009-98

Cited by 5 publications

(9 citation statements)

References 21 publications

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“…[ 15 ] found that the discharge time was almost twice the recovery time, whereas, in our study, the mean recovery time ( P > 0.05) and the discharge time ( P > 0.05) were comparable between both the groups, as it could be explained by the low rates of propofol infusion (75 and 100 µg/kg/min). Adverse effects like nausea and vomiting were seen more with the propofol–ketamine combination[ 15 16 ], but in our study, none of the patients in either group had postprocedure vomiting. Better quality of images was obtained with Group KP.…”

Section: Discussionmentioning

confidence: 55%

Comparison of airway collapsibility following single induction dose ketamine with propofol versus propofol sedation in children undergoing magnetic resonance imaging: A randomised controlled study

Bhardwaj,

Panneerselvam,

Rudingwa

et al. 2024

Indian Journal of Anaesthesia

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Background and Aims: Adequate sedation is essential for children undergoing magnetic resonance imaging (MRI) console. Propofol is commonly used for sedation, but it has the drawback of upper airway collapse at higher doses, which may be overcome by ketamine. This study was designed to evaluate the beneficial effect of ketamine on propofol in preventing airway collapse. Methods: Fifty-eight children undergoing MRI were randomised to Group P (propofol bolus dose followed by infusion or Group KP (bolus dose of ketamine and propofol followed by propofol infusion). The primary aim is to compare the upper airway cross-sectional area (CSA) and diameters (transverse diameter [TD] and anteroposterior diameter [APD]) obtained from MRI during inspiration and expiration. Results: Upper airway collapse as measured by delta CSA in mean (SD) [95% confidence interval] was statistically more significant between the two groups [at the soft palate level, 16.9 mm2 (19.8) [9.3–24.4] versus 9.0 mm2 (5.50) [6.9–11.1] (P = 0.043); at the base of the tongue level, 15.4 mm2 (11.03) [11.2–19.6] versus 7.48 mm2 (4.83) [5.64–9.32] (P < 0.001); at the epiglottis level, 23.9 (26.05) [14.0–33.8] versus 10.9 mm2 (9.47) [7.35–14.5] (P = 0.014)]. A significant difference was obtained for TD at all levels and for APD at the soft palate and base of tongue level. Conclusion: Adding a single dose of ketamine to propofol reduced the upper airway collapse significantly, as evidenced by the MRI-based measurements of upper airway dimensions, compared to propofol alone.

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Section: Discussionmentioning

confidence: 55%

Comparison of airway collapsibility following single induction dose ketamine with propofol versus propofol sedation in children undergoing magnetic resonance imaging: A randomised controlled study

Bhardwaj,

Panneerselvam,

Rudingwa

et al. 2024

Indian Journal of Anaesthesia

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“…Studies have shown that combining ketamine at doses of 0.5–1 mg/kg anesthesia applied in pediatric magnetic resonance imaging and laparoscopic cholecystectomy in adults could increase the incidence of PONV. 32 , 33 Nevertheless, adjuvant fentanyl with ketamine at 0.3 mg/kg for self‐controlled intravenous analgesia after thoracic spine surgery did not increase the incidence of PONV. 34 So, it could be thought that S‐ketamine at the dose of 0.2–0.3 mg/kg was not considered sufficient to increase the incidence of nausea and vomiting.…”

Section: Discussionmentioning

confidence: 91%

“…PONV effects of S‐ketamine are considered dose‐dependent like those triggered by ketamine. Studies have shown that combining ketamine at doses of 0.5–1 mg/kg anesthesia applied in pediatric magnetic resonance imaging and laparoscopic cholecystectomy in adults could increase the incidence of PONV 32,33 . Nevertheless, adjuvant fentanyl with ketamine at 0.3 mg/kg for self‐controlled intravenous analgesia after thoracic spine surgery did not increase the incidence of PONV 34 .…”

Section: Discussionmentioning

confidence: 99%

Thrifty effect of subanesthetic‐dose S‐ketamine on postoperative opioids and its safety and analgesic effectiveness: A prospective, triple‐blind, randomized controlled, polycentric clinical trial

Ding,

Yu,

Luo

et al. 2023

Ibrain

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Aim: To investigate the thrifty effects of subanesthetic-dose S-ketamine on postoperative opioids and its safety and analgesic efficacy. Methods: Four-hundred and twenty patients were divided into the control group (CON group), the S-ketamine 0.2 mg/kg group (ES0.2 group), and the S-ketamine 0.3 mg/kg group (ES0.3 group) randomly. Major indicators include the Visual Analogue Scale (VAS), the times of compression with analgesic pumps after surgery, and analgesic drug consumption from anesthesia induction to 48 h after surgery. Minor records include vital signs, the use of vasoactive drugs, the Ramsay scores, the occurrence of adverse events including nervous system reaction, and the patient's satisfaction with anesthesia.Results: Compared with the CON group, VAS scores decreased in the ES0.2 and ES0.3 groups (p < 0.05). At 10 min after extubation, the VAS scores of the ES0.3 group were lower than that of the ES0.2 group (p < 0.05). The total number of compression with analgesic pumps of the ES0.3 group was lower than that of the CON group (p < 0.05). The opioid consumption after surgery of the ES0.3 group was lower than those of the CON group and the ES0.2 group (p < 0.05). The ES0.3 group's heart rate (HR) was faster but the use of vasoactive, drug consumption was less than the other two groups (p < 0.05).There were no significant differences in the incidence of postoperative adverse events and anesthetic satisfaction among the three groups.Conclusion: Subanesthetic-dose S-ketamine at 0.2-0.3 mg/kg especially the 0.3 mg/kg in general anesthesia induction can safely and effectively reduce postoperative pain and save postoperative opioid consumption.

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“…The commonly used anesthesia methods are propofol plus low-dose fentanyl intravenous analgesia and intravenous combined inhalation anesthesia [ 28 ]. Propofol plus low-dose fentanyl sedation is commonly used in short-term outpatient surgery, such as gastrointestinal endoscopy and induced abortion.…”

Section: Discussionmentioning

confidence: 99%

Comparing Different Anesthesia Methods on Anesthetic Effect and Postoperative Pain in Patients with Early Gastric Cancer during Endoscopic Submucosal Dissection

Zhang¹,

Chen²,

Liu³

et al. 2022

Journal of Oncology

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Endoscopic submucosal dissection (ESD) is a minimally invasive technique to completely peel the pathological mucosa from the submucosa under endoscopy, which has been often utilized to treat early gastric cancer. During the operation, anesthesia is required to reduce the discomfort due to the complexity, high risk, and longtime operation of ESD. In this study, we compared different anesthesia methods on anesthetic effect and postoperative pain in patients (≥65 years old) with early gastric cancer during ESD. For this purpose, 60 patients with early gastric cancer who were more than 65 years old were selected from January 2019 to December 2021, where 30 patients treated with simple intravenous general anesthesia were divided into the simple group and 30 patients treated with intravenous combined inhalation general anesthesia were regarded as the composite group. The hemodynamic index, wake-up time, postoperative pain intensity, operation time, and the incidence of adverse reactions were compared between the two groups. For the hemodynamic index before incision, after incision, and at the end of the operation, the mean arterial pressure (MAP) in the composite group was higher than that in the simple group P < 0.05 and the heart rate (HR) was lower than that in the simple group P < 0.05 . After the ESD operation, the wake-up time and visual analogue scale (VAS) in the composite group were lower than those in the simple group P < 0.05 . In addition, the ESD operation time and incidence of adverse reactions in the composite group was significantly lower than that in the simple group P < 0.05 . These results showed that intravenous combined inhalation general anesthesia had a good anesthetic effect, stable hemodynamics during ESD operation, and slight postoperative pain.

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Investigation of the effects of propofol/ketamine versus propofol/fentanyl on nausea- vomiting administered for sedation in children undergoing magnetic resonance imaging: a prospective randomized double-blinded study

Cited by 5 publications

References 21 publications

Comparison of airway collapsibility following single induction dose ketamine with propofol versus propofol sedation in children undergoing magnetic resonance imaging: A randomised controlled study

Comparison of airway collapsibility following single induction dose ketamine with propofol versus propofol sedation in children undergoing magnetic resonance imaging: A randomised controlled study

Thrifty effect of subanesthetic‐dose S‐ketamine on postoperative opioids and its safety and analgesic effectiveness: A prospective, triple‐blind, randomized controlled, polycentric clinical trial

Comparing Different Anesthesia Methods on Anesthetic Effect and Postoperative Pain in Patients with Early Gastric Cancer during Endoscopic Submucosal Dissection

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