Background/aim: In this study, we aimed to compare the effects of propofol-ketamine and propofol-fentanyl sedations on post-procedure nausea-vomiting in children undergoing magnetic resonance imaging (MRI). Materials and methods:This study included 100 pediatric patients (2-10 years old) who had propofol-ketamine and propofol-fentanyl for sedation to undergo MRI. The patients were divided into two groups, and sedation was performed through propofolketamine (Group K; n=50) or propofol-fentanyl (Group F; n=50). For sedation induction, intravenous (IV) bolus of 1.2 mg/kg propofol and 1 mg/kg ketamine were administered in Group K, IV bolus of 1.2 mg/kg propofol and 1 µg/kg fentanyl in Group F. All patients received 0.5 mg/kg IV bolus propofol in additional doses when the Ramsey Sedation Score (RSS) was below 4 for maintenance. Perioperative heart rate, systolic arterial pressure, peripheral oxygen saturation, respiratory rate, and nauseavomiting scores were recorded for each patient.Results: There was no difference between the groups in terms of nausea incidences at the 1 st hour. However, the rate of vomiting was significantly higher in Group K. Conclusion:In our study, we showed that the vomiting rate was higher in the 1 st hour in Group K compared to Group F.