Investigation of the Peripheral Analgesic Activity of Oxicams and Their Combinations with Caffeine

CREATION OF ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITIONS (review)

“…It is known to be a psychostimulant, found in coffee, tea, energy and many beverages. Caffeine is found in plants such as coffee, tea, cocoa and others [41][42][43][44][45][46][47][48][49][50][51][52].…”

“…and others with caffeine were studied. Our long-term research has shown that caffeine enhances the pharmacological effects of NSAIDs of different chemical structure and analgesics [41-52], so we believe that caffeine is a suitable adjuvant of NSAIDs of different chemical structure in terms of anti-inflammatory and analgesic effects [41][42][43][44][45][46][47][48][49][50][51][52]. Due to the fact that pharmaceutical compositions with coxibs are not available on the pharmaceutical market, we decided to create Rofecoxib is also widely used in clinical practice in Ukraine [58].…”