Investigation of the relationship between GSTM1 gene variations and serum trace elements, plasma malondialdehyde levels in patients with colorectal cancer

Ay, Arzu; Gülyaşar, Tevfik; Alkanlı, Nevra; Sipahi, Tammam; Çiçin, İrfan; Koçak, Zafer; Süt, Necdet

doi:10.1007/s11033-021-06694-2

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…[ 35 ] MDA is a product of LPO that has been demonstrated to be involved in formation of tumors. [ 36 ] In our present study, enhanced MDA levels observed in lung cancer‐bearing animals could be due to the excessive free radicals produced by administration of B(a)P. TQ supplementation resulted in the free radical quenching effect, resulting in significantly decreased levels of MDA in B(a)P‐induced animals. This evidently indicates that TQ by its antioxidant effect inhibited LPO thereby curbing the formation of LPO products that are involved in carcinogenesis.…”

Section: Discussionmentioning

confidence: 53%

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Nithya

Rajasekaran

Vanitha

et al. 2022

J Biochem & Molecular Tox

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Several studies have suggested that increased consumption of phytochemicals is a comparatively easy and practical strategy to significantly decrease the incidence of cancer. In the present study, we have reported the protective effect of a natural compound, thymoquinone (TQ) against benzo(a)pyrene (B(a)P)‐induced lung carcinogenesis in Swiss albino mice. B(a)P (50 mg/kg body weight) was administered twice weekly for four successive weeks and left until 20 weeks to induce lung cancer in mice. TQ (20 mg/kg body weight) was given orally as a pretreatment and posttreatment drug to determine its chemopreventive and therapeutic effects. B(a)P‐induced lung cancer‐bearing animals displayed cachexia‐like symptoms along with an abnormal increase in lung weight and the activities of marker enzymes adenosine deaminase, aryl hydrocarbon hydroxylase, gamma‐glutamyl transpeptidase, 5′‐nucleotidase and lactate dehydrogenase; tumor marker carcinoembryonic antigen levels. Furthermore, B(a)P‐induced animals showed elevated levels of lipid peroxides with subsequent depletion in the antioxidant status and histological aberrations. These anomalies were accompanied by increased expressions of proliferating cell nuclear antigen and cyclin D1 in the lung sections derived from B(a)P‐induced animals. On TQ treatment, all the above alterations were returned to near normalcy. Furthermore, TQ administration in B(a)P‐induced animals downregulated phosphatidylinositol 3‐kinase/protein kinase B signaling pathway and induced apoptosis as evidenced by a decrease in cytochrome c, proapoptotic Bax, caspase‐3, and p53 with a parallel increase in antiapoptotic Bcl‐2. Our present results demonstrate the potential effectiveness of TQ as an antioxidant, antiproliferative, and apoptotic agent against B(a)P‐induced experimental lung tumorigenesis.

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Section: Discussionmentioning

confidence: 53%

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Nithya

Rajasekaran

Vanitha

et al. 2022

J Biochem & Molecular Tox

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“…Piling of MDA in individuals is correlated with many disease states including liver injury, human immunodeficiency virus, cancer, and diabetes mellitus. MDA formation is stimulated in the plasma of various carcinomas and obese patients 3,4,5,6,7,8,9,10,11 . Similar increase in animal models was seen upon induction with carcinogens into the tissues of the mice 6,8 .…”

Section: Introductionmentioning

confidence: 99%

Effect of oxidative stress markers in breast carcinoma patients

Kumar

John

Shareef

et al. 2022

ijhs

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Background: Curiosity in view of the literature regarding breast cancer especially in our country, there has been little study on breast cancer individuals during and progression of the cancer on oxidative stress markers. Aim: To determine the effect of MDA, TAC, SOD, Catalase, reduced glutathione in breast cancer subjects and to compare them with the apparently healthy controls. Methods: Lately diagnosed female subjects with breast cancer in the age group of 40-60 years were included in the study. Apparently healthy controls were selected from the group of people who were attending for annual health check-up and found to be healthy. Results: On comparison between the two groups, the present study observed significant differences in the values of MDA, TAC, and reduced glutathione. Interestingly, we observed higher levels of MDA in the subjects suffering with breast carcinoma, whereas lower levels in the apparently healthy controls incorporated in the study. Comparing between the groups of LDL and HDL level, the present study observed significant difference. Conclusion: The present study concludes that alterations in the study parameters in breast cancer group are due to dys-balance oxidants production and lower expression of antioxidants.

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“…GSTM1 can inhibit the activity of apoptosis-regulatory kinase 1 (ASK1) (21), an MAP kinase that induces the death of cytotoxic tumor cells by activating the JNK and p38 pathways (22)(23)(24). Multiple studies have indicated that a lack of GSTM1 may contribute to the occurrence of malignant tumors, including colon cancer (25,26), liver cancer (27), and breast cancer (28). Reported experimental results have suggested GSTM1 could be a potential target for colon cancer treatment; however, direct evidence is needed to reveal the role of GSMT1 in colon cancer tumor immunity to support this notion.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the correlation between GSTM1 and tumor immunity in colon cancer

Luo¹,

Tang²,

Ling³

et al. 2022

J Gastrointest Oncol

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Background: Glutathione S-transferase mu 1 (GSTM1) is one of the major glutathione conjugation enzymes. Its expression and activity have been suggested to correlate with the occurrence of colon cancer; however, the role of GSTM1 in tumor immunity remains unclear.Methods: Relevant data downloaded from The Cancer Genome Atlas (TGGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC), and Human Protein Atlas (HPA) was used to perform a multi-dimensional expression analysis of GSTM1 in colon adenocarcinoma (COAD). The correlation between GSTM1 and tumor immunity was analyzed with multiple online tools. Then protein-protein interaction (PPI) network and functional enrichment analyses of GSTM1-associated immunomodulators were performed. Further, we developed the Cox regression model based on the GSTM1-related immunomodulators. Finally, a GSTM1based clinical nomogram and a calibration curve was established to predict the probability and accuracy of long-term survival.Result: GSTM1 was significantly downregulated in COAD versus normal tissues. Infiltration levels of B cells, CD8 + T cells, and dendritic cells were closely correlated to GSTM1 gene copy number deletion, and GSTM1 expression levels in COAD positively correlated with dendritic cell, B cell, neutrophil, and macrophage infiltration. Functional enrichment analysis indicated 36 GSTM1-related immunomodulators are involved in immune-related pathways of regulating T cell activation and lymphocytic activation. A 2-gene prognostic risk signature based on the 36 GSTM1-related immunomodulators was built using the Cox regression model, and the risk signature in combination with stage had an area under the curve (AUC) value of 0.747 by the receiver operating characteristic method. patients with higher risk scores-calculated based on 2 gene prognostic risk characteristics and further identified as an independent prognostic factorwere associated with worse survival using the Kaplan-Meier analysis. Together, the clinical nomogram and calibration curve based on GSTM1 suggested a good prediction accuracy for long-term survival probability.Conclusions: Our study provided evidence supporting the significant role of GSTM1 in COAD immunity and suggests GSTM1 as a potential novel target for COAD immunotherapy.

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Investigation of the relationship between GSTM1 gene variations and serum trace elements, plasma malondialdehyde levels in patients with colorectal cancer

Cited by 7 publications

References 35 publications

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo(a)pyrene‐induced experimental lung cancer

Effect of oxidative stress markers in breast carcinoma patients

Comprehensive analysis of the correlation between GSTM1 and tumor immunity in colon cancer

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