Investigation on the Efficacy of Povidone-Iodine against Antiseptic-Resistant Species

Kunisada, Toshiyuki; Yamada, K.; Oda, Seiji; Hara, Osamu

doi:10.1159/000246025

Cited by 110 publications

(85 citation statements)

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“…However, Pseudomonas aeruginosa strains exhibiting raised MIC to chlorhexidine have been observed [29] and MRSA strains with decreased susceptibility have been frequently isolated from clinical settings [30,31]. While other studies also reported the development of resistance towards chlorhexidine [32,33], this was not found in the present study. Although a slight increase in the IC 50 was noted, the change was statistically not significant.…”

Section: Discussioncontrasting

confidence: 57%

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Analysis of the Adaptation Capacity of Staphylococcus aureus to Commonly Used Antiseptics by Microplate Laser Nephelometry

Wiegand

Abel

Ruth

et al. 2012

Skin Pharmacol Physiol

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Background: Bacterial colonization and infection are important factors in compromised wound healing. Antiseptics have become an alternative for antimicrobial applications as antibiotic resistance is increasing; they have multiple targets with a broad spectrum of activity. Hence, the risk for developing resistance should be low. However, concerns have been raised that their growing use may result in bacteria that are less susceptible. Methods: The capacity of common antiseptics such as silver nitrate, polihexanide, octenidine, chlorhexidine and polyvinylpyrrolidone (PVP)-iodine to induce adaptation in a Staphylococcus aureus strain was analyzed in vitro using microplate laser nephelometry. S. aureus was repeatedly incubated with the respective half maximal inhibitory concentration (IC₅₀) over a time period of 100 days. The influence of the continued treatment was determined by in situ monitoring of changes in the dose-response curves and calculation of the current IC₅₀ values for the substances tested. Results: During the experiment, S. aureus quickly adapted to high concentrations of the antibiotic mupirocin during repeated treatment. Moreover, a significant increase of the IC₅₀ for silver nitrate was observed over time. On the other hand, no significant difference was observed for polihexanide or chlorhexidine. While the IC₅₀ for octenidine was also found to increase significantly, although the change was only marginal, reiterated incubation with PVP-iodine led to a decrease in the IC₅₀. Conclusion: Repeated treatment of S. aureus with polihexanide, chlorhexidine, octenidine and PVP-iodine did not trigger bacterial adaptation to these substances.

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Section: Discussioncontrasting

confidence: 57%

“…Furthermore, PVP-iodine shows high bactericidal activity against resistant bacteria strains, e.g. MRSA or Enterococcus faecium [37] and it was shown that it does not induce adaptation in bacteria [32]. In fact the results presented here prove that repeated treatment with PVP-iodine even led to a more susceptible S. aureus strain in vitro.…”

Section: Discussionmentioning

confidence: 63%

Analysis of the Adaptation Capacity of Staphylococcus aureus to Commonly Used Antiseptics by Microplate Laser Nephelometry

Wiegand

Abel

Ruth

et al. 2012

Skin Pharmacol Physiol

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“…saliva, which may suppress the antibacterial properties of antiseptics. On the other hand, methicillin-resistant Staphylococcus aureus (MRSA) resistant to chlorhexidine gluconate (CHG) and benzalkonium chloride as well as other bacterial antiseptics have been reported [1,2,3,4,5]. In fact, oral antiseptics are not always effective in killing MRSA colonizing the pharynx in some patients.…”

Section: Introductionmentioning

confidence: 99%

In vitro Short-Time Killing Activity of Povidone-Iodine (Isodine® Gargle) in the Presence of Oral Organic Matter

Yoneyama

Shimizu²,

Tabata³

et al. 2006

Dermatology

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In order to estimate the clinical efficacy of a povidone-iodine oral antiseptic (PVP-I) on oral bacterial infectious diseases, we studied the effect of oral organic matter on the in vitro killing activity of PVP-I. In addition, we compared the in vitro short-time killing activity of PVP-I with those of other oral antiseptics using mouth-washing and gargling samples collected from healthy volunteers. When any of the mouth-washing and gargling samples was used, the standard (0.23–0.47%) or lower concentrations of PVP-I killed methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, including multidrug-resistant strains, within 15–60 s in the presence of oral organic matter. 0.02% benzethonium chloride (BEC) and 0.002% chlorhexidine gluconate (CHG) did not show effects against MRSA and P. aeruginosa (including multidrug-resistant strains) in mouth-washing and gargling samples even after 60 s. The above-mentioned results show that the in vitro killing activity of the standard concentration of PVP-I was hardly affected by the oral organic matter and that a mouth-washing or gargling solution containing PVP-I has a stronger bactericidal activity than BEC and CHG. Although mouth-washing and gargling samples were obtained from healthy individuals in this study, PVP-I may be used for protection against infections in patients with various diseases, if proper concentrations and usage are encouraged.

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“…However, solution with 1:10,000 dilution still presents bactericidal activity. 64,65 Potential disadvantages of povidone-iodine solution are tendency for an irritation to the applied site, cytotoxicity and staining of the tissues. Although in some in-vivo and animal studies the cytotoxicity was observed, these results were not confirmed in humans.…”

Section: E Povidone-iodine Solutionmentioning

confidence: 99%

Negative pressure wound therapy with instillation (NPWTi): Current status, recommendations and perspectives in the context of modern wound therapy.

Bobkiewicz

Studniarek

Drews

et al. 2016

NPWTJ

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REVIEWAbstract-Introduction of negative pressure wound therapy (NPWT) revolutionized the conception of wound healing. Currently, increasing number of studies confirmed the high efficiency of this therapy in many clinical scenarios. Moreover, some innovations have been introduced in recent years to improve the management of complex and chronic wounds. NPWT with instillation (NPWTi) combines traditional NPWT with application of topical irrigation solutions within the bed of the wound. Bioburden reduction, decreases time to wound closure, promotes granulation and tissue formation. Fewer operative visits are required when using NPWTi compared to standard NPWT. However, there are still questioned aspects of the NPWTi and thus its superiority over standard NPWT has not been fully indicated. Moreover, based on current studies no firm conclusions have been taken concerning the type of instilled solution preferably used, range of dwell-time phase, range of negative pressure and others. The main goal of the publication is to overview and summarize the current state of art concerning NPWTi. Moreover, mechanisms of action, review of the most commonly used instilled solutions are discussed and clinical evidence of NPWTi are described.

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Investigation on the Efficacy of Povidone-Iodine against Antiseptic-Resistant Species

Cited by 110 publications

References 0 publications

Analysis of the Adaptation Capacity of <b><i>Staphylococcus aureus</i></b> to Commonly Used Antiseptics by Microplate Laser Nephelometry

Analysis of the Adaptation Capacity of <b><i>Staphylococcus aureus</i></b> to Commonly Used Antiseptics by Microplate Laser Nephelometry

In vitro Short-Time Killing Activity of Povidone-Iodine (Isodine<sup>®</sup> Gargle) in the Presence of Oral Organic Matter

Negative pressure wound therapy with instillation (NPWTi): Current status, recommendations and perspectives in the context of modern wound therapy.

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