Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization

Baneshi, Nazanin; Moghadas, Bahareh Kamyab; Adetunla, Adedotun; Yusof, Mohd Yusmiaidil Putera Mohd; Dehghani, Mohammad; Khandan, Amirsalar; Saber‐Samandari, Saeed; Toghraie, Davood

doi:10.1016/j.jmrt.2021.10.107

Cited by 31 publications

(5 citation statements)

References 53 publications

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“…In various studies, it was reported that the scaffolds produced using different methods for bone regeneration have a porous structure. [51][52][53] The pores in all scaffolds are arranged as interconnected pores, indicating that the pores in the scaffolds provide sufficient space for cell adhesion and proliferation. In Figure 8(d), it is seen that nanoparticle formulations were prepared successfully and they show a monodisperse distribution.…”

Section: Characterization Of Scaffoldsmentioning

confidence: 99%

Silk fibroin nanoparticles and β–tricalcium phosphate loaded tissue engineered gelatin bone scaffolds: A Nature-based, low-cost solution

Yıldız,

Birer,

Turgut Birer

et al. 2023

J Biomater Appl

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Tissue engineering has recently attracted attention as an alternative to traditional treatment methods for tissue and organ damage. Since bone is one of the most important vital parts of the body, the treatment of bone damage is important. Silk fibroin is a natural polymer with properties such as biocompatibility and biodegradability, which attracts attention with its controlled release, especially in drug delivery systems. In this study, gelatin-based scaffolds loaded with silk fibroin nanoparticles and β -tricalcium phosphate (β -TCP) were developed to be used as a potential drug delivery system in bone tissue engineering. The chosen nanoparticle formulation has a 294 nm average diameter with a 0.380 polidispersity index (PDI). In vitro characterization of scaffolds was performed by mechanical, morphological characterization, swelling capacity, Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FT-IR) measurements, and biocompatibility was evaluated by cell culture studies. Swelling index, tensile strength, elongation at break, and Young modulus of the β -TCP and silk nanoparticles loaded scaffold were found as 456%, 1.476 MPa, 6.75%, and 24 MPa, respectively. In vitro cell culture studies have shown that scaffolds prepared in the present study can accelerate osteoblast differentiation and increase the healing rate of bone tissues. In addition, they have the potential to be used as a drug delivery system in bone tissue engineering that needs to be evaluated with further studies.

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Section: Characterization Of Scaffoldsmentioning

confidence: 99%

Silk fibroin nanoparticles and β–tricalcium phosphate loaded tissue engineered gelatin bone scaffolds: A Nature-based, low-cost solution

Yıldız,

Birer,

Turgut Birer

et al. 2023

J Biomater Appl

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“…[ 52 ] Freeze‐dried scaffolds present interconnected 3D networks with over 90% porosity, offering ideal biomimetic microenvironments for the spreading, proliferation, and differentiation of cells. [ 53 ] However, the simple planar geometries and lack of microstructural control hinder their use for applications where well‐engineered architectures are required, such as 3D tissue shaping and culture [4b,54] . Recently, some progress have been made in addressing the aforementioned issues.…”

Section: Fabrication Methods For Polymeric Tissue Scaffoldsmentioning

confidence: 99%

Polymeric Scaffolds for Regeneration of Central/Peripheral Nerves and Soft Connective Tissues

Cao

Zhang

2023

Advanced NanoBiomed Research

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The advancement in material science and fabrication techniques has led to the booming of tissue engineering in recent years, covering tissue culture, repair, regeneration, and the rest. Among the aforementioned, considering the indispensable roles of central/peripheral nerve and soft connective tissues playing in life‐sustaining activities, their regenerations have attracted intense research attention, especially using polymeric scaffolds, an easy‐to‐access, cost efficient, biocompatible and diverse family of engineering materials. Herein, commonly used natural and synthetic polymeric materials for tissue scaffolds are outlined. Specially, polymer‐based hybrids, being able to provide both structural support and bio‐microenvironments, are discussed. Additionally, representative manufacturing approaches for polymeric scaffolds, including freeze‐drying, electrospinning, 3D printing, soft lithography among others are highlighted. Notably, combined techniques (e.g., electrospinning, 3D printing, etc.) allowing tailorable structural configurations of composite polymeric scaffolds are also reviewed. Furthermore, recent achievements in central/peripheral nerve and soft connective tissues regenerations using polymeric scaffolds are discussed in detail. In the end, conclusions and outlooks are provided to draw a roadmap for future research.

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“…Bone loss resulting from critical fractures, tumor resection, or osteoporosis often requires the use of multiple therapeutic methods such as corrective surgery, radiation, and targeted drug administration. [ 21 ] Supplements of exogenous scaffolds are used to support reconstruction and facilitate the regeneration of surrounding soft tissue. [ 22 ] Despite autografts or allografts being conventionally used, this procedure has limitations such as immunogenic reactions, postoperative pain, graft and donor site morbidity, and structural imperfections.…”

Section: Introductionmentioning

confidence: 99%

3D‐Printed Polyetheretherketone Smart Polymer Nanocomposite Scaffolds: Mechanical, Self‐Sensing, and Biological Attributes

Schneider,

Basak,

Hou

et al. 2024

Adv Eng Mater

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This study demonstrates the mechanical, self‐sensing and biological characteristics of carbon nanotubes (CNTs) and graphene nanoplatelets (GNPs) engineered 3D‐printed PEEK composite scaffolds, utilising custom‐made feedstocks. Microstructural analysis and macroscale testing reveal that the PEEK/CNT scaffolds with 6wt.% CNT content and 46% relative density, achieve a gauge factor of up to 75, a modulus of 0.64 GPa, and a compressive strength of 64 MPa. The PEEK/CNT2.5/GNP2.5 scaffolds evince still better performance, at a relative density of 73%, reporting a modulus of up to 1.1 GPa and a compressive strength of 122 MPa. Importantly, stability in mechanical and piezoresistive performance up to 500 cycles is noted, indicating a durable and reliable performance under cyclic loading. Murine pre‐osteoblast cells (MC3T3‐E1) are used to biologically characterise sulfonated scaffolds over 14 days. Cytotoxicity, DNA, and alkaline phosphatase (ALP) levels are quantified through in vitro assays, evaluating cell viability, proliferation and osteogenic properties. Notably, PEEK/CNT 6wt.% scaffolds exhibit nearly 80% cytocompatibility, while PEEK/CNT2.5/GNP2.5 scaffolds reach nearly 100%. Both types of scaffolds support cell differentiation, as evidenced by elevated ALP levels. These findings carry significant promise in bone tissue engineering, paving the way for the development of adaptive, intelligent structural implants boasting enhanced biocompatibility and self‐sensing capabilities.This article is protected by copyright. All rights reserved.

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Investigation the mechanical properties of a novel multicomponent scaffold coated with a new bio-nanocomposite for bone tissue engineering: Fabrication, simulation and characterization

Cited by 31 publications

References 53 publications

Silk fibroin nanoparticles and β–tricalcium phosphate loaded tissue engineered gelatin bone scaffolds: A Nature-based, low-cost solution

Silk fibroin nanoparticles and β–tricalcium phosphate loaded tissue engineered gelatin bone scaffolds: A Nature-based, low-cost solution

Polymeric Scaffolds for Regeneration of Central/Peripheral Nerves and Soft Connective Tissues

3D‐Printed Polyetheretherketone Smart Polymer Nanocomposite Scaffolds: Mechanical, Self‐Sensing, and Biological Attributes

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