Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy

Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells

“…For example in sarcomas, the small molecule inhibitor of c-Kit, imatinib, has dramatically changed the treatment and prognosis of gastrointestinal stromal tumors (GIST) [6]. Several protein kinase pathways have been found to be up-regulated or amplified in liposarcomas, including the proto-oncogenes PI3K/AKT [7] and C-Jun [8,9]. Amplification and over-expression of these kinase pathways are thought to be an early and essential part of the oncogenic program of liposarcoma.…”

c‐Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme

“…A c-Jun deoxyribozyme was also recently shown to induce apoptosis in SW872 liposarcoma cells in vitro and inhibit their ability to form tumours in mice [6]. We analysed the role of c-Jun in liposarcomas by evaluating a series of liposarcomas for c-Jun amplification and for c-Jun and ASK1 protein levels.…”

DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

“…However, later studies revealed that Dz13 is effective against tumors directly [91][92][93][94][95] and probably independently from downregulation of c-jun [43] (see chapter 2).…”

“…Transfection into human erythroleukaemia cell lines of the Dzs designed to bind to t12-lipoxygenase (LOX) mRNA resulted in significant downregulation of 12-LOX Early growth response-1 A zinc finger transcription factor upregulated by mechanical injury to vascular smooth muscle cells and endothelial cells [89,90] c-jun Involved in regulating proliferation, transformation and apoptosis; the protein contains 'leucine zipper' domain and forms homo-and heterodimers resulting in AP-1 factor formation [40,43,[91][92][93][94][95][96] VEGFR1 Important targets in anti-cancer therapy due to their involvement in angiogenesis [36] VEGFR2 [97] Human platelet type 12 lipoxygenase…”