Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of ellagic acid in the rat formalin test

Mansouri, Mohammad Taghi; Naghizadeh, Bahareh; Ghorbanzadeh, Behnam

doi:10.1016/j.pbb.2014.02.009

Cited by 32 publications

(28 citation statements)

References 37 publications

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“…According to the previous reports, ellagic acid and gallic acid exhibit analgesic potential through peripheral and central mechanisms [19][20][21]7]. EtOAc showed analgesic potential through both peripheral and central components.…”

Section: Discussionmentioning

confidence: 95%

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Phytochemical Constituents and Analgesic Activity of Ethyl Acetate Fraction of Punicagranatum L (Punicaceae)

Hwi¹

2015

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 95%

“…Ellagic acid has been reported to possess both peripheral and central anti-nociceptive activities when tested by writhing test and hot tail flick test [19,20]. Some studies have confirmed the antinociceptive effects of gallic acid in models of acute pain such as the acetic acid writhing test and cyclophosphamide-elicited cystitis [9,21].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Constituents and Analgesic Activity of Ethyl Acetate Fraction of Punicagranatum L (Punicaceae)

Hwi¹

2015

Trop. J. Pharm Res

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“…The reference drug, indomethacin (10 mg/kg, i.p. ), were also used for comparison (16). Carrageenan was injected under the plantar region of right hind paw, and the volume was measured using a plethysmometer (UGO Basile, Italy) at hours one, two, three, four, and five of carrageenan challenge.…”

Section: Experimental Groupsmentioning

confidence: 99%

“…Numerous preclinical and some clinical studies suggest that flavonoids have potentials for the prevention and treatment of several diseases (14,15). Furthermore, they have shown different pharmacologic effects including anti-inflammatory and antinociceptive effects (16)(17)(18), improvement of learning behavior (19), and antioxidant, anti-aging, and antineoplastic characteristics (13,20,21).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effect of Hydroalcoholic Extract of the Washingtonia filifera Seeds in Carrageenan-Induced Paw Edema in Rats

Hemmati

Kalantari‬

Siahpoosh

et al. 2015

Jundishapur J Nat Pharm Prod

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Background:Medicinal plants are believed to be important sources of new chemical substances with potential therapeutic effects. Washingtonia filifera is characterized by its high content of flavonoids. Numerous studies suggest that flavonoids have potential for the prevention and treatment of several diseases. Objectives: This study aimed to investigate the anti-inflammatory activity of the Washingtonia filifera seeds' hydroalcoholic extract (WSE). Materials and Methods:The hydroalcoholic extract was administered to male Wistar rats. Carrageenan-induced paw edema was used to evaluate the anti-inflammatory activity. The WSE (100, 200, and 400 mg/kg) or vehicle were administered intraperitoneally 30 minutes before the subplantar injection of carrageenan. Intraperitoneal indomethacin (10 mg/kg) was used as standard drug. Results: The intraperitoneal WSE (100 -400 mg/kg) produced the anti-inflammatory effect in a dose-dependent manner with a median effective dose (ED50) of 164.4 mg/kg (124.16 -203.7 mg/kg). Furthermore, the anti-inflammatory effect of WSE was comparable to indomethacin (10 mg/kg) Conclusions: These results indicated that WSE has a potent anti-inflammatory action and confirmed that the extract contains an effective anti-inflammatory substance(s).

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“…It has been reported to show different pharmacological effects, including chemoprevention and antioxidant (Festa et al 2001;Townsend & Tew 2003), inhibition of tumorigenesis (Buniatian 2003), antinociception and anti-inflammation (Mansouri et al , 2014, inhibition of anaphylactic reaction in vivo and in vitro (Choi & Yan 2009), inhibition of lipopolysaccharide-induced prostaglandin E2 synthesis in human monocytes (Karlsson et al 2010), antidepressant (Girish et al 2012) and also anxiolytic (Girish et al 2013) activities.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

Mansouri

Farbood

Naghizadeh

et al. 2016

Pharmaceutical Biology

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(2016) Beneficial effects of ellagic acid against animal models of scopolamine-and diazepam-induced cognitive impairments, Pharmaceutical Biology, 54:10, 1947-1953, DOI: 10.3109/13880209.2015 PHARMACEUTICAL BIOLOGY, 2016 VOL. 54, NO. 10, 1947-1953 http://dx.doi.org/10.3109/13880209.2015 Context In a previous study, it has been shown that ellagic acid (EA), a polyphenolic compound found in pomegranate and different berries, prevents cognitive and hippocampal long-term potentiation (LTP) impairments induced by traumatic brain injury in rats through antioxidant and anti-inflammatory mechanisms.Objective The present study was conducted to assess the potential of EA as a memory enhancer. Materials and methodsThe elevated plus maze (EPM) and passive avoidance (PA) paradigm were used to evaluate learning and memory parameters. Three doses (10, 30 and 100 mg/kg, i.p.) of EA were administered to animals. Memory impairment was induced by scopolamine treatment (0.4 mg/kg, i.p.) and/or diazepam (1 mg/kg, i.p.). Acquisition trials were carried out 30 min after scopolamine treatment and retention trials were performed for 5 min 24 h after the acquisition trials.Results EA at doses 30 and 100 mg/kg significantly reversed the amnesia induced by scopolamine (0.4 mg/kg, i.p.) in the EPM and PA tests in mice. Also, EA at doses 30 and 100 mg/kg significantly antagonized the amnesia induced by diazepam (1 mg/kg, i.p.) in EPM test in rats. Moreover, chronic administration of EA at dose 30 mg/kg ameliorated the memory deficit induced by diazepam (1 mg/ kg, i.p.) in rats. Discussion and conclusion This study demonstrates that ellagic acid is effective in preventing scopolamine-and diazepam-induced cognitive impairments without altering the animals' locomotion. This suggests the potential of EA application as a useful memory restorative agent in the treatment of dementia seen in elderly persons.ARTICLE HISTORY

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Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of ellagic acid in the rat formalin test

Cited by 32 publications

References 37 publications

Phytochemical Constituents and Analgesic Activity of Ethyl Acetate Fraction of Punicagranatum L (Punicaceae)

Phytochemical Constituents and Analgesic Activity of Ethyl Acetate Fraction of Punicagranatum L (Punicaceae)

Anti-inflammatory Effect of Hydroalcoholic Extract of the Washingtonia filifera Seeds in Carrageenan-Induced Paw Edema in Rats

Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments

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