Iodochlorhydroxyquinoline and Diiodohydroxyquinoline: Animal Toxicity and Absorption in Man 1

David, Norman A.; Phatak, Nilkanth M.; Zener, F.B.

doi:10.4269/ajtmh.1944.s1-24.29

Cited by 21 publications

(10 citation statements)

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“…For instances, the average iodide concentrations of 2.2 and 1.7 µg/ml in blood were attained at clinical doses of amebacides, i.e. Diodoquin and Vioform, respectively (David et al, 1944). Most iodine-containing contrast media are contaminated with inorganic iodide, (I − ), at concentrations in the order of ppm.…”

Section: Discussionmentioning

confidence: 99%

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

et al. 2004

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-We hypothesize that iodine allergy is an immune response to iodinated autologous proteins generated in vivo from iodine-containing organic and inorganic chemicals. In this report, effects of protein iodination on elicitogenic activity in guinea pig iodine allergy model and iodinated protein antigen generation in vitro from iodine-containing chemicals were investigated.Active cutaneous anaphylaxis (ACA) and delayed-type hypersensitivity (DTH) tests were performed in guinea pigs immunized with iodine. The amount of iodine (I 2 ) reacted to proteins for giving them an eliciting activity of ACA was ≥0.15 µmol for 1 mg of albumin. DTH reactions were provoked by intradermal injection of 10 6 PECs reacted with ≥0.075 µmol of I 2 . I 2 was generated from a potassium iodide (KI) solution or iodinated contrast media by UV light irradiation. X-ray irradiation of KI and iodinated contrast media in the presence of protein resulted in the generation of iodinated protein antigens. The generation of iodinated protein antigens was inhibited in the presence of reducing agents. Therefore, it is noteworthy that iodine allergy of the present hypothesis is dependent on reactive oxygens. By presenting these ex vivo and in vitro data, we discuss the possibilities for the generation of iodinated protein antigens in vivo.

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Section: Discussionmentioning

confidence: 99%

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

et al. 2004

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“…These findings were later confirmed (3). It was also shown that despite its very poor water-solubility there was a considerable absorption of ICOQ (2,3,7) and that in man the iodine content of the blood rose markedly after administration of ICOQ and DIOQ (2). It is by now well known that administration of ICOQ substantially elevates the iodine content in the blood and that the PBI may remain elevated for considerable periods of time (5,8).…”

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confidence: 99%

Metabolism of 125Iodochloroxyquinoline in Man

Liewendahl¹,

Lamberg²

1967

Nuklearmedizin

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SummaryThe absorption and excretion of 125I-labelled iodochloroxyquinoline (Vio-form®, CIBA) was studied in 3 euthyroid and 3 hyperthyroid subjects. The tracer doses of 0.1—1.0mg/kg or 7.6—60mg, and corresponding to 38.5—68 μCi, were given orally.The average absorption amounted to 43.6 per cent as judged from the urinary excretion during the period of study (10—18 days). The absorption was very rapid, the highest plasma concentration values (0.63—6.5 per cent of the dose/1) being invariably found in the first plasma sample drawn 4 hrs after administration. In two cases the faecal excretion was measured. It amounted to 33 and 64 per cent, the total urinary und faecal recovery in these cases being about 95 per cent in 6—9 days. The thyroid uptake was very low, about 0.4 per cent, and corresponded to 0.11 mg of iodine.The plasma disappearance curves consisted of two or more components. The initial rapid phase had a T1/2 of about 0.3 days and the last phase a T1/2 of 11 days, on the average. The urinary excretion curve showed an initial phase corresponding to a single exponential function and lasted for several days after which the curve attained a more horizontal direction. In two euthyroid subjects there was a spontaneous increase in the urinary excretion, starting on the days 7 and 11 and lasting for several days. This coincided with an increase in the absolute dialysable plasma radioactivity.There was also a constant increase in the dialysable fraction during the experiment. This was thought to indicate a relative increase in one or several highly water-soluble metabolites. The use of TCA-precipitation for studying the protein-bound portion gave higher values for the nonprotein-bound portion in the beginning of the experiment. This was probably due to splitting from the plasma proteins of some loosely bound metabolites. At the end of the experiment both methods gave more equal values for the nonprotein-bound fraction.The renal clearance for the plasma dialysable fraction above a concentration of 15—23 ng/ml was that of a substance actively secreted by the tubules. The maximal renal clearance calculated from the total plasma concentration averaged 12 ml/min.Attempts were made to study the effect of hyperthyroidism and thyroid blocking agents on the distribution of 125ICOQ. In hyperthyroid cases the initial disposal rate appeared to be faster than in the euthyroid cases. In the later phase, however, the plasma curve and the urinary excretion remained on a higher level. The result of thyroid blocking agents was inconclusive.

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“…Pharnmacology.-Widespread oral use of the drug for amoebiasis has shown that it is relatively non-toxic in man (David et al, 1944). In vitro it inhibits Staph.…”

Section: Medical Journalmentioning

confidence: 99%

Topical Use of Vioform

Overton¹

1949

BMJ

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Iodochlorhydroxyquinoline and Diiodohydroxyquinoline: Animal Toxicity and Absorption in Man 1

Cited by 21 publications

References 0 publications

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

Metabolism of 125Iodochloroxyquinoline in Man

Topical Use of Vioform

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