A double-blind, placebo-controlled study was carried out in 231 adult patients suffering from acute diffuse pharyngitis or acute tonsillitis with fever and dysphagia to assess the effectiveness of niflumic acid combined with standard antibiotic therapy in relieving pain and inflammation. Patients were allocated at random to receive either 4 capsules of 250 mg niflumic acid or placebo daily in addition to 1.5 million units phenoxymethyl penicillin for 4 to 5 days. Clinical assessments before and after 2 and 4 days of treatment showed that there was faster resolution of fever, pain, adenopathy, pharyngeal congestion and dysphagia, and improved patient comfort in the niflumic acid group. Few side-effects were recorded and there were only 4 drop-outs due to side-effects in patients receiving niflumic acid.
Hurst28 states that from time to time there is a close connection between trauma and the development of a gastric ulcer, though he quotes no percentages. Ein¬ horn 29 makes a similar observation.The thought is thrown out merely as a suggestion that perhaps mild traumas have been overlooked in the anamnesis of ulcer cases ; given an ulcer constitution and chemism, may not seemingly mild trauma be a more frequent deciding etiologic factor than has hitherto been admitted? CRITICAL SUMMARY Liniger and Molineus 30 have specified certain pos¬ tulates that need to be satisfied before a case of sus¬ pected traumatic ulcer may be accepted as a true example of such a lesion.
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