The Pharmacology of Dimethyl Sulfoxide

David, Norman A.

doi:10.1146/annurev.pa.12.040172.002033

Cited by 172 publications

(88 citation statements)

References 33 publications

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“…It is possible, albeit unlikely, that sources produce DMSO in high enough local concentrations that it could exist in the solid state. A more likely scenario is that DMSO could exist in pseudoparticulate form by adsorbing to the silicate and calcite surfaces of marine diatoms and coccolithophorids, given its strong capacity to adsorb to positively charged surface (7,16). Finally, cold temperatures may inhibit diffusion of DMSO into the cell.…”

Section: Discussionmentioning

confidence: 99%

Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1

Gralnick

Vali

Lies

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

199

209

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Shewanella species are renowned for their respiratory versatility, including their ability to respire poorly soluble substrates by using enzymatic machinery that is localized to the outside of the cell. The ability to engage in ''extracellular respiration'' to date has focused primarily on respiration of minerals. Here, we identify two gene clusters in Shewanella oneidensis strain MR-1 that each contain homologs of genes required for metal reduction and genes that are predicted to encode dimethyl sulfoxide (DMSO) reductase subunits. Molecular and genetic analyses of these clusters indicate that one (SO1427-SO1432) is required for anaerobic respiration of DMSO. We show that DMSO respiration is an extracellular respiratory process through the analysis of mutants defective in type II secretion, which is required for transporting proteins to the outer membrane in Shewanella. Moreover, immunogold labeling of DMSO reductase subunits reveals that they reside on the outer leaflet of the outer membrane under anaerobic conditions. The extracellular localization of the DMSO reductase in S. oneidensis suggests these organisms may perceive DMSO in the environment as an insoluble compound.DMSO ͉ metabolism ͉ cold temperature adaptation

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Section: Discussionmentioning

confidence: 99%

Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1

Gralnick

Vali

Lies

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

199

209

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“…Divalent cations are adept at shielding phosphates, and form much more stable co-ordination complexes with phosphate than do monovalent cations (Sillen, 1964). DMSO is very effective at solvating metallic cations (Meek et al, 1960;David, 1972), and should be particularly effective at organizing and stabilizing ionic interactions along boundaries between hydrophobic lipid bilayers and the aqeous environment. Thus these compounds may be facilitating the otherwise unlikely association of two phosphate-rich structures.…”

Section: (B) Specificity and Channels In Transformationmentioning

confidence: 99%

Studies on transformation of Escherichia coli with plasmids

Hanahan

1983

Journal of Molecular Biology

10,357

4,255

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Factors that affect the probability of genetic transformation of Escherichia coli by plasmids have been evaluated. A set of conditions is described under which about one in every 400 plasmid molecules produces a transformed cell. These conditions include cell growth in medium containing elevated levels of Mg 2+. and incubation of the cells at 0~ in a solution of Mn 2+, ("a 2+, Rb + or K +, dimethyl sulfoxide, dithiothreitol, and hexamine cobalt (III). Transibrmation efficiency declines linearly with increasing plasmid size. Relaxed and supercoiled plasmids transfol'm with similar probabilities. Non-transforming DNAs compete consistent with mass. No significant variation is observed between competing DNAs of difi~rent source, complexity, length or form. Competition with both transforming and nontransforming plasmids indicates that each cell is capable of taking up many DNA molecules, and that the establishment of a transformation event is neither helped nor hindered significantly by the presence of multiple plasmids.

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“…By becoming incorporated below the hydrophilic head group in a nonspecific manner, molecules of DMSO increase the average head group area and the amenability to bending in the lipid membranes, the entry of water molecules is then facilitated, inducing non-specific water pore formation. 44 However, although the dermal application of DMSO did not show significant toxicity in earlier studies, it was reported that 45 Moreover, Hanslick et al reported that DMSO could induce widespread apoptotic neurodegeneration in the central nervous system of juvenile mice, and possibly caused similar damage in children. Even at a concentration as low as 0.5%, DMSO could lead to apoptosis in the central nervous system, and at the postnatal age of 7 and 30 which are equivalent to human childhood ages, severe damage was observed after DMSO exposure.…”

Section: Discussionmentioning

confidence: 98%

Selective inhibition of MG-63 osteosarcoma cell proliferation induced by curcumin-loaded self-assembled arginine-rich-RGD nanospheres

Chang¹,

Sun²,

Webster³

2015

IJN

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Osteosarcoma is the most frequent primary malignant form of bone cancer, comprising 30% of all bone cancer cases. The objective of this in vitro study was to develop a treatment against osteosarcoma with higher selectivity toward osteosarcoma cells and lower cytotoxicity toward normal healthy osteoblast cells. Curcumin (or diferuloylmethane) has been found to have antioxidant and anticancer effects by multiple cellular pathways. However, it has lower water solubility and a higher degradation rate in alkaline conditions. In this study, the amphiphilic peptide C18GR7RGDS was used as a curcumin carrier in aqueous solution. This peptide contains a hydrophobic aliphatic tail group leading to their self-assembly by hydrophobic interactions, as well as a hydrophilic head group composed of an arginine-rich and an arginine-glycine-aspartic acid structure. Through characterization by transmission electron microscopy, self-assembled structures of spherical amphiphilic nanoparticles (APNPs) with diameters of 10–20 nm in water and phosphate-buffered saline were observed, but this structure dissociated when the pH value was reduced to 4. Using a method of codissolution with acetic acid and dialysis tubing, the solubility of curcumin was enhanced and a homogeneous solution was formed in the presence of APNPs. Successful encapsulation of curcumin in APNPs was then confirmed by Fourier transform infrared and X-ray diffraction analyses. The cytotoxicity and cellular uptake of the APNP/curcumin complexes on both osteosarcoma and normal osteoblast cell lines were also evaluated by methyl-thiazolyl-tetrazolium assays and confocal fluorescence microscopy. The results showed that the curcumin-loaded APNPs had significant selective cytotoxicity against MG-63 osteosarcoma cells when compared with normal osteoblasts. We have demonstrated for the first time that APNPs can encapsulate hydrophobic curcumin in their hydrophobic cores, and curcumin-loaded APNPs could be an innovative treatment for the selective inhibition of osteosarcoma cells.

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The Pharmacology of Dimethyl Sulfoxide

Cited by 172 publications

References 33 publications

Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1

Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1

Studies on transformation of Escherichia coli with plasmids

Selective inhibition of MG-63 osteosarcoma cell proliferation induced by curcumin-loaded self-assembled arginine-rich-RGD nanospheres

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The Pharmacology of Dimethyl Sulfoxide

Cited by 172 publications

References 33 publications

Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1

Extracellular respiration of dimethyl sulfoxide by Shewanella oneidensis strain MR-1

Studies on transformation of Escherichia coli with plasmids

Selective inhibition of MG-63 osteosarcoma cell&nbsp;proliferation induced by curcumin-loaded self-assembled arginine-rich-RGD nanospheres

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Selective inhibition of MG-63 osteosarcoma cell proliferation induced by curcumin-loaded self-assembled arginine-rich-RGD nanospheres