Ion-imprinted supermacroporous cryogel, for in vitro removal of iron out of human plasma with beta thalassemia

Monolithic cryogels made of agarose–chitosan composite and loaded with agarose beads for purification of immunoglobulin G

“…The IgG adsorption capacity decreased significantly from 28.5 to 4.0 mg/g with the increase of the flow rate from 1.0 to 7.0 mL/min. This may due to the decrease in contact time between IgG and the matrix at higher flow rates, these results were in good agreement with those reported [27,30]. Moreover, the column pressure drop only increased slightly during the whole experiment, indicating the obtained cryogels could In order to observe the effect of equilibrium IgG concentration on adsorption capacity, the equilibrium IgG concentration in the range of 0-2.5 mg/mL was investigated.…”

Poly(hydroxyethyl methacrylate) based affinity cryogel for plasmid DNA purification

“…Supermacroporous cryogels are a very good alternative for the purification of large molecules like DNA with many advantages including large pores and short diffusion path [20][21][22][23][24][25][26]. The large pores of cryogels will allow penetration of large pDNA molecules to the internal surface area at high flow rate with low pressure drops [27].…”

Molecularly imprinted composite cryogels for hemoglobin depletion from human blood

“…High back-pressure is not a problem for cryogel columns, whereas it is an important problem for conventional columns composed of microspheres. However, big pores bring along a disadvantage, which is low surface area to cryogels that results in low binding capacity of cryogel column (Yao et al, 2007;Baydemir et al, 2009;Aslıyüce et al, 2010;Koç et al, 2011;Hajizadeh et al, 2012). Composite cryogels increase the surface area by embedding microspheres because of high surface area of microspheres (Yao et al, 2006;Le Noir et al, 2007;Bereli et al, 2010;Ivanov et al, 2012;Sun et al, 2012a;Sun et al, 2012b).…”