Ion mobility-derived collision cross section database: Application to mycotoxin analysis

Righetti, Laura; Bergmann, Andreas; Galaverna, Gianni; Rolfsson, Óttar; Paglia, Giuseppe; Dall’Asta, Chiara

doi:10.1016/j.aca.2018.01.047

Cited by 65 publications

(65 citation statements)

References 31 publications

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“…While not an exhaustive list, a few of the larger libraries to note are: Li and colleagues' peptide database which includes >2300 CCS values,13 Pagel and colleagues' glycomics database of >900 CCS values,14 and Xu and colleagues' small molecule database containing >1400 CCS values 15. Additionally, many excellent smaller CCS libraries have been generated for lipids,16–18 primary metabolites,18–20 secondary metabolites and other natural products,18,21,22 as well as illicit substances23 among others.…”

Section: Introductionmentioning

confidence: 99%

Collision cross section compendium to annotate and predict multi-omic compound identities

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Collision cross section compendium to annotate and predict multi-omic compound identities

et al. 2019

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“…The new technique is reliable if the extract is subjected to a prior immunoaffinity cleanup and is valid for selection purposes. Righetti et al () have developed ion‐mobility application to detect different mycotoxins such as AFs, OTA, HT‐2, T‐2, ZEA, PAT, DON, and fumonisins in wheat, malt, maize, and rye. The tests demonstrated high reproducibility (relative standard deviation (RSD) < 2%) in various instrument conditions and were not influenced by complex sample matrices, showing a RSD < 0.9%.…”

Section: Detection Techniquesmentioning

confidence: 99%

Rapid and sensitive detection of mycotoxins by advanced and emerging analytical methods: A review

Singh

Mehta

2020

Food Science & Nutrition

149

108

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Quantification of mycotoxins in foodstuffs is extremely difficult as a limited amount of toxins are known to be presented in the food samples. Mycotoxins are secondary toxic metabolites, made primarily by fungal species, contaminating feeds and foods. Due to the presence in globally used grains, it is an unpreventable problem that causes various acute and chronic impacts on human and animal health. Over the previous few years, however, progress has been made in mycotoxin analysis studies. Easier techniques of sample cleanup and advanced chromatographic approaches have been developed, primarily high-performance liquid chromatography. Few extremely sophisticated and adaptable tools such as high-resolution mass spectrometry and gas chromatography-tandem MS/MS have become more important. In addition, Immunoassay, Advanced quantitative techniques are now globally accepted for mycotoxin analysis. Thus, this review summarizes these traditional and highly advance methods and their characteristics for evaluating mycotoxins. K E Y W O R D Sadvanced quantitative techniques, chromatography, immunological, mycotoxins, spectroscopy 2184 | SINGH aNd MEHTa ultraviolet, fluorescence, photomultiplier, ion mobility, and tandem mass spectrophotometry, fourier transforms near infrared, adsorptive stripping voltammetry, and their lower detection limits, and sensitivity of different types of matrice has been reviewed. For the determination of mycotoxins, traditional quantitative methods viz. chromatography, immunological, and the advanced methods viz. ultrahigh-performance liquid chromatography, fluorescence polarization immunoassay, nanoparticle-based methods, microfluidics, and phage display methods have been discussed extensively in this review.

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“…However, several concerns have been raised such as the lack of CCS databases and the tolerance accepted for CCS measurements. While, until a few years ago, CCS had been barely used as verification parameter in screening approaches due to the lack of databases, this situation has now recently changed and several CCS databases for pesticides [112,113], veterinary drugs [114,115,116], mycotoxins [117] and other contaminants [108], have been reported in the last five years.…”

Section: Applications Of Ims In Food Analysismentioning

confidence: 99%

Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends

et al. 2019

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In the last decade, ion mobility spectrometry (IMS) has reemerged as an analytical separation technique, especially due to the commercialization of ion mobility mass spectrometers. Its applicability has been extended beyond classical applications such as the determination of chemical warfare agents and nowadays it is widely used for the characterization of biomolecules (e.g., proteins, glycans, lipids, etc.) and, more recently, of small molecules (e.g., metabolites, xenobiotics, etc.). Following this trend, the interest in this technique is growing among researchers from different fields including food science. Several advantages are attributed to IMS when integrated in traditional liquid chromatography (LC) and gas chromatography (GC) mass spectrometry (MS) workflows: (1) it improves method selectivity by providing an additional separation dimension that allows the separation of isobaric and isomeric compounds; (2) it increases method sensitivity by isolating the compounds of interest from background noise; (3) and it provides complementary information to mass spectra and retention time, the so-called collision cross section (CCS), so compounds can be identified with more confidence, either in targeted or non-targeted approaches. In this context, the number of applications focused on food analysis has increased exponentially in the last few years. This review provides an overview of the current status of IMS technology and its applicability in different areas of food analysis (i.e., food composition, process control, authentication, adulteration and safety).

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Ion mobility-derived collision cross section database: Application to mycotoxin analysis

Cited by 65 publications

References 31 publications

Collision cross section compendium to annotate and predict multi-omic compound identities

Collision cross section compendium to annotate and predict multi-omic compound identities

Rapid and sensitive detection of mycotoxins by advanced and emerging analytical methods: A review

Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends

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