Ion sensitive floating <i>In situ</i> gel for controlled delivery of famotidine and domperidone maleate for the treatment of gastro oesophageal reflux disease

Jorapur, Devika; Nagesh, C; Suma, N.; Chandrasekhara, S; Attimarad, Sunil L; Kengeri, Savitha

doi:10.5958/0974-360x.2018.00389.x

Rese. Jour. of Pharm. and Technol.

2018

DOI: 10.5958/0974-360x.2018.00389.x

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Ion sensitive floating In situ gel for controlled delivery of famotidine and domperidone maleate for the treatment of gastro oesophageal reflux disease

Devika Jorapur¹,

C Nagesh²,

N. Suma³

et al.

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Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Shabaraya,

T Ashwini,

Vineetha

2023

European Pharmaceutical Journal

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A revolutionary concept for achieving long-term medication release is the gastroretentive in situ gelling system. The goal of this research was to formulate and test a gastroretentive in situ gel for ketoprofen delivery to targeted site to increase the residence and delivery time. Ketoprofen gastroretentive in situ gels were synthesized using a cation-driven gelation approach using various combinations and concentrations of polymers such as gellan gum, sodium alginate, and hydroxypropyl methylcellulose (HPMC) K100M. Visual appearance, pH, viscosity, in vitro gelation, in vitro buoyancy, drug content, density measurement, gel strength measurement, water uptake, and in vitro drug release were all evaluated. The total floating time was more than 12 h, with a floating lag time of less than 2 min. The formulations showed pH ranging from 6.89 to 7.61 and drug content ranging from 82.01% to 95.53%. For 11 h, the percent cumulative drug release of formulations F5 and F14, which contained a greater concentration of polymer sodium alginate (1.5%) and a combination of gellan gum and HPMC K100M (0.175% and 0.2%), was 84.10% and 85.49%, respectively. In vitro dissolution experiments and stability investigations both revealed no significant changes in drug content. The findings revealed that the formulated in situ gels aided in extending gastric residence duration, allowing the drug to be released in the stomach.

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Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Shabaraya,

T Ashwini,

Vineetha

2023

European Pharmaceutical Journal

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Gel Based Formulations in Oral Controlled Release Drug Delivery

Biswas¹,

Mishra²,

Sufian³

2022

RJPT

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Gel-based formulations may be classified as hydrogels, emulgels, and organogels or oleogels. This categorization depends on the polarity of the liquid component present in it. Hydrogels offer excellent potential to be used in oral drug delivery due to inherent biocompatibility, diversity of both natural and synthetic components. In particular, stimuli-responsive hydrogels can meet the physiological changes along the gastro intestinal tract to achieve site-specific, controlled release of protein, peptide and many other molecules for systemic treatment. There are many different techniques for the preparation of different sort of customized hydrogel. In recent years the popularity of oleogels is also in increasing order due to the easy method of preparation and inherent long-term stability of these products to provide the ideal drug delivery matrix. Oleogels are comprised of non-polar dispersion medium like fixed oil, mineral oil, organic solvents which are gelled with organogelator. Most of the studies on oleogels has been conducted on their use in food applications. Hydrogel and oleogel both have good acceptance in the field of oral drug delivery. This review work highlights brief description about both Hydrogels and Oleogels focusing their characteristics, advantages, disadvantages, application, some major techniques of the preparations and modifications of the same in oral drug delivery.

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Ion sensitive floating In situ gel for controlled delivery of famotidine and domperidone maleate for the treatment of gastro oesophageal reflux disease

Cited by 2 publications

References 0 publications

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Gel Based Formulations in Oral Controlled Release Drug Delivery

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