Ion substitutions and non-stoichiometry of carbonated apatite-(CaOH) synthesised by precipitation and hydrothermal methods

Frank-Kamenetskaya, O. V.; Kol’tsov, A. B.; Kuzmina, Maria; Zorina, M. L.; Poritskaya, Lilya

doi:10.1016/j.molstruc.2011.02.013

Cited by 120 publications

(30 citation statements)

References 24 publications

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“…This effect may be caused by the incorporation of hydrocarbonate anions into the structure of formed calcium phosphates (the formation of carbonate hydroxylapatite), accompanied by a decrease in their solubility in comparison with brushite. Insoluble calcium carbonates (solubility products SP (СаСО 3 ) = 6.03 × 10 -9 and SP (CaHРО 4 ⋅ 2Н 2 О) = 2.34 × 10 -7 [4]). Carbonate ions most significantly affect the nucleation in the DPF system.…”

Section: Influence Of Inorganic and Organic Impurities On Nucleationmentioning

confidence: 99%

“…It is known that crystallization in the DPF system leads generally to the formation of one compound: calcium hydrophosphate (brushite), while in the model saliva solution octacalcium phosphate is crystallized along with calcium hydrophosphate [4]. The difference in the induction times of different phases is responsible for their different nucleation times, which cause polymodal distribution.…”

Section: Granulometry Of Crystallization Productsmentioning

confidence: 99%

“…One of the urgent lines of research in crystallization from solutions is investigating crystallization in biological media [1][2][3][4][5][6][7][8][9]. The studies carried out in this field are important for several reasons.…”

Section: Introductionmentioning

confidence: 99%

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Main features of nucleation in model solutions of oral cavity

2015

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The regularities of nucleation in model solutions of oral cavity have been investigated, and the induction order and constants have been determined for two systems: saliva and dental plaque fluid (DPF). It is shown that an increase in the initial supersaturation leads to a transition from the heterogeneous nucleation of crystallites to a homogeneous one. Some additives are found to enhance nucleation: > C 6 H 12 O 6 > F -, while others hinder this process: protein (casein) > Mg 2+ . It is established that crystallization in DPF occurs more rapidly and the DPF composition is favorable for the growth of small (52.6-26.1 μm) crystallites. On the contrary, the conditions implemented in the model saliva solution facilitate the formation of larger (198.4-41.8 μm) crystals.

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Section: Influence Of Inorganic and Organic Impurities On Nucleationmentioning

confidence: 99%

Section: Granulometry Of Crystallization Productsmentioning

confidence: 99%

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Main features of nucleation in model solutions of oral cavity

2015

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“…The resorption process may be enhanced through ionic substitution of phosphate and hydroxide anions in the apatite structure for carbonate, silicate and other groups [4]. The carbonate-substituted hydroxyapatites are similar to the mineral components of the natural bone in their composition and structure, and silicate ions in the HA composition play a bridging role in the physiological processes of growth and restoration of bone and cartilaginous tissues, etc.…”

Section: Introductionmentioning

confidence: 99%

“…A significant disadvantage of the HA-based material most frequently used for implantation is its low bioresorbability rate. This problem can be solved through chemical modification of calcium phosphate, since it is known that isomorphic impurities introduced into calcium phosphate may increase both its bioactive properties and solubility.The resorption process may be enhanced through ionic substitution of phosphate and hydroxide anions in the apatite structure for carbonate, silicate and other groups [4]. The carbonate-substituted hydroxyapatites are similar to the mineral components of the natural bone in their composition and structure, and silicate ions in the HA composition play a bridging role in the physiological processes of growth and restoration of bone and cartilaginous tissues, etc.…”

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confidence: 99%

Bio resorbability of the modified hydroxyapatite in Tris-HCL buffer

Голованова

Измайлов

Ghyngazov

2016

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. The solubility of carbonated hydroxyapatite powders and granulated carbonated hydroxyapatite produced from the synovial biofluid model solution has been studied. The kinetic characteristics of dissolution were determined. It was found that the solubility of carbonated hydroxyapatite is higher as compared to that of hydroxyapatite. The impact of the organic matrix on the rate of sample dissolution was revealed. For HA-gelatin composites, as the gelatin concentration grows, the dissolution rate becomes greater, and a sample of 6.0 g / L concentration has higher resorbability. The results of the research can be used to study the kinetics of dissolution and the biocompatibility of ceramic materials for medicine, namely for reconstructive surgery, dentistry, and development of drug delivery systems. IntroductionCurrently, much attention is paid to studying and improving the bioactive properties of the materials produced based on calcium phosphates. Interest in these compounds is due to the fact that the human bone tissue is a biocomposite based on hydroxyapatite (HA) with an admixture of amorphous calcium phosphates, brushite, octacalcium phosphate [1,2] and high-protein collagen. Therefore, calcium phosphate-based materials are widely used in medicine for bone defect replacement [3]. However, widespread use of these compounds is hindered by some problems. The most significant of the problems is low dissolution (i.e. bioresorption) rate of calcium phosphate-based materials. A significant disadvantage of the HA-based material most frequently used for implantation is its low bioresorbability rate. This problem can be solved through chemical modification of calcium phosphate, since it is known that isomorphic impurities introduced into calcium phosphate may increase both its bioactive properties and solubility.The resorption process may be enhanced through ionic substitution of phosphate and hydroxide anions in the apatite structure for carbonate, silicate and other groups [4]. The carbonate-substituted hydroxyapatites are similar to the mineral components of the natural bone in their composition and structure, and silicate ions in the HA composition play a bridging role in the physiological processes of growth and restoration of bone and cartilaginous tissues, etc. One of the most frequently used forms of phosphate calcium HA-based ceramics are granules, coatings and other forms, in which collagen, gelatin and chitosan are used as matrix-carriers. As is well-known, the human body contains buffer solutions, and the study of the resorption processes of the bioactive samples based on HA is one of the urgent issues to promote practical application of these products.The most common buffer simulating the physiological medium of the human body is Tris-HCl buffer with, pH equal to 7.4. Since pH of this buffer is similar to the physiological values of the organism, this buffer was used as the solvent to simulate the medium of a living organism.

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The use of poly (ε‐caprolactone) to enhance the mechanical strength of porous Si‐substituted carbonate apatite

Bang

Kawachi

Nakagawa

et al. 2013

J of Applied Polymer Sci

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Poly(ε‐caprolactone) (PCL)/silicon‐substituted carbonate apatite (Si‐CO3Ap) composite derived from the interconnected porous Si‐CO3Ap reinforced with molten PCL was prepared. PCL was used to improve the mechanical properties of a porous apatite by a simple polymer infiltration method, in which the molten PCL was deposited through the interconnected channel of porous Si‐CO3Ap. The PCL covered and penetrated into the pores of the Si‐CO3Ap to form an excellent physical interaction with Si‐CO3Ap leading to a significant increase in diametral tensile strength from 0.23 MPa to a maximum of 2.04 MPa. The Si‐CO3Ap/PCL composite has a porosity of about 50–60% and an interconnected porous structure, with pore sizes of 50–150 μm which are necessary for bone tissue formation. These results could pave the way for producing a porous, structured biocomposite which could be used for bone replacement. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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Ion substitutions and non-stoichiometry of carbonated apatite-(CaOH) synthesised by precipitation and hydrothermal methods

Cited by 120 publications

References 24 publications

Main features of nucleation in model solutions of oral cavity

Main features of nucleation in model solutions of oral cavity

Bio resorbability of the modified hydroxyapatite in Tris-HCL buffer

The use of poly (ε‐caprolactone) to enhance the mechanical strength of porous Si‐substituted carbonate apatite

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