Ionic liquid-based microwave-assisted extraction of verbascoside from Rehmannia root

Fan, Yunchang; Xu, Chunxiang; Li, Jing; Zhang, Lei; Yang, Lei; Zhou, Zhulin; Zhu, Yahui; Zhao, Dan

doi:10.1016/j.indcrop.2018.07.063

Cited by 23 publications

(9 citation statements)

References 38 publications

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“…In the current study, the entire IL-MA-SLE consumes less time, 15 min compared to the 45 min required in the UA-SLE method. Moreover, MW power is energetic enough to deal with the plant matrix while allowing a faster diffusion of the target compounds to the solvent [ 45 , 46 ]. Another important advantage of the method proposed in this study in comparison with the more conventional method and our previous study [ 20 ] is the use of an IL of low cytotoxicity (which only requires ethanol in the synthetic procedure), thus gaining in greenness over the organic solvent required in the UA-SLE method, and the imidazolium IL utilized in our previous MA-SLE method [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Structurally Different Ionic Liquid-Based Surfactants in a Green Microwave-Assisted Extraction for the Flavonoids Profile Determination of Mangifera sp. and Passiflora sp. Leaves from Canary Islands

et al. 2020

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Aqueous solutions of ionic liquids (ILs) with surface active properties were used as extraction solvents, taking advantage of their impressive solvation properties, in a green microwave-assisted solid-liquid extraction method (IL-MA-SLE) for the extraction of flavonoids from passion fruit and mango leaves. The extraction method was combined with high-performance liquid chromatography and photodiode-array detection (HPLC-PDA) and optimized by response surface methodology using the Box-Behnken experimental design. Under optimum conditions, the extraction efficiency of six structurally different IL-based surfactants was evaluated. Thus, imidazolium-, guanidinium- and pyridinium-type ILs with different tailorable characteristics, such as side chain length and multicationic core, were assessed. The decylguanidinium chloride ([C10Gu+][Cl–]) IL-based surfactant was selected as key material given its superior performance and its low cytotoxicity, for the determination of flavonoids of several samples of Passiflora sp. and Mangifera sp. leaves from the Canary Islands, and using as target analytes: rutin, quercetin and apigenin. The analysis of 50 mg of plant material only required 525 µL of the low cytotoxic IL-based surfactant solution at 930 mM, 10.5 min of microwave irradiation at 30 °C and 50 W, which involves a simpler, faster, more efficient and greener method in comparison with other strategies reported in the literature for obtaining bioactive compounds profiles from plants.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Structurally Different Ionic Liquid-Based Surfactants in a Green Microwave-Assisted Extraction for the Flavonoids Profile Determination of Mangifera sp. and Passiflora sp. Leaves from Canary Islands

et al. 2020

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“…Phenylethanoid-phenylpropanoid glycosides (PPGs) are widely distributed compounds in the kingdom of plants, most of these compounds isolated from medicinal plants, which are soluble in water and organic solvents [12]. This kind of glycosides are not specific to any organ in the plant, they have been isolated from plant leaves, aerial parts, barks, roots, callus and cell cultures [13] [14]. Most of these glycosides reported yet, were isolated from Plantaginaceae, Orobanchaceae Scrophulariaceae, Lamiaceae, Oleaceae and Lamiaceae families [15].…”

Section: Introductionmentioning

confidence: 99%

Verbascoside—A Review of Its Antitumor Activities

Khalaf¹,

Jasim²,

Ibrahim³

2021

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Cancer is a set of diseases including abnormal growth of cells that can spread to another tissue. Verbascoside (or acteoside) is a naturally occurring, water-soluble secondary metabolite with significant biological properties, which is distributed widely in plant kingdom. Verbascoside is pharmacologically active compounds with many recent evidences that support its biological activities and safety. This review focuses on the recent studies that concerned with the antitumor activities of verbascoside alone and as a synergistic agent as well as nanoproduct. It also shows the latest advances in its antitumor effects, cytotoxic selectivity and its efficiencies in treating cancer, in vitro and/or vivo.

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“…Recently, ionic liquids (ILs) have become promising alternatives to the traditional organic solvents employed in sample preparation because of their unique properties, such as negligible vapor pressure, high thermal stability, non-flammability and good solubility for many inorganic and organic compounds [17]. Therefore, ILs have been extensively applied as substituents for conventional organic solvents in various extraction processes including salt-induced liquid-liquid extraction (SI-LLE) [18], dispersive liquid-phase microextraction (DLPME) [19], microwave-assisted extraction (MAE) [20], pressurized liquid extraction [21], ultrasonic-assisted extraction [22][23][24] and temperature-controlled liquid phase micro-extraction (TC-LPME) [25][26][27][28]. In this context, hydrophobic ILs are usually used to extract liquid samples, while hydrophilic ILs are mostly used to extract solid samples.…”

Section: Introductionmentioning

confidence: 99%

Determination of Ferulic Acid in Angelica sinensis by Temperature-Controlled Hydrophobic Ionic Liquids-Based Ultrasound/Heating-Assisted Extraction Coupled with High Performance Liquid Chromatography

Huang

Chao

et al. 2020

Molecules

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Hydrophilic ionic liquids are often used to extract the active ingredients of medicinal plants, while hydrophobic ionic liquids are rarely used to directly extract solid samples. In this paper, a simple, novel and efficient temperature-controlled hydrophobic ionic liquids-based ultrasound/heating-assisted extraction (TC-ILs-UHAE) procedure coupled with high-performance liquid chromatography (HPLC) was developed and applied to the determination of ferulic acid (FA) in Chinese herbal medicine Angelica sinensis. During the extraction procedure, hydrophobic ionic liquids (ILs) were dispersed into water to form cloudy solution (fine droplets) with the aid of ultrasound and heating simultaneous. After extraction, phase separation was easily achieved by centrifuging at 0 °C. Among all ILs used, 1-butyl-3-methylimidazolium bis(trifluoromethanesulphonyl)imide ([C4mim]NTf2) exhibited the highest extraction ability and the possible extraction mechanism was discussed. Additionally, the synergistic effect of heating and ultrasound on the extraction efficiency was investigated. Under the optimized conditions, a good linearity was observed with correlation coefficient (r) of 0.9995. The limit of detection of FA (LOD, S/N = 3) was 9.6 µg/L and the spiked recoveries of FA for real samples were in the range of 91.67 to 102.00% with relative standard deviation (RSD) lower than 3.87%. Compared with the traditional extraction methods, the proposed method gave the highest yield of FA and had the shortest extraction time. Therefore, this method is a potential simple, green and highly efficient technique and expected to be applied to the extraction of other bioactive ingredients in medicinal plants.

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Ionic liquid-based microwave-assisted extraction of verbascoside from Rehmannia root

Cited by 23 publications

References 38 publications

Evaluation of Structurally Different Ionic Liquid-Based Surfactants in a Green Microwave-Assisted Extraction for the Flavonoids Profile Determination of Mangifera sp. and Passiflora sp. Leaves from Canary Islands

Evaluation of Structurally Different Ionic Liquid-Based Surfactants in a Green Microwave-Assisted Extraction for the Flavonoids Profile Determination of Mangifera sp. and Passiflora sp. Leaves from Canary Islands

Verbascoside—A Review of Its Antitumor Activities

Determination of Ferulic Acid in Angelica sinensis by Temperature-Controlled Hydrophobic Ionic Liquids-Based Ultrasound/Heating-Assisted Extraction Coupled with High Performance Liquid Chromatography

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