Ionoregulatory disruption as the acute toxic mechanism for lead in the rainbow trout (Oncorhynchus mykiss)

Rogers, Joseph T.; Richards, Jeff G.; Wood, Chris M.

doi:10.1016/s0166-445x(03)00053-5

Cited by 157 publications

(83 citation statements)

References 56 publications

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“…However, it has lower sensitivity to metals compared to other ATPases (Lemaire-Gony and Mayer-Gostan, 1994;Lionetto et al, 2000;Atli and Canli, 2013). Pb 2+ inhibited Ca 2+ -ATPase in fish muscle and as a result, changes in calcium levels were observed (Rogers et al, 2003). Studies also showed that Ca 2+ -ATPase activity decreased in several tissues of fish after metal exposures, possibly inhibiting Ca 2+ transport (Wong and Wong, 2000;Rogers and Wood, 2004;Atli and Canli, 2011a).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that Pb 2+ causes disruption of Na + , Cl -and Ca 2+ regulation and disruption in hemoglobin synthesis (Hodson et al, 1978;Rogers et al, 2003Rogers et al, , 2005Rogers and Wood, 2004 , by which this metal directly competes with Ca 2+ for uptake at calcium binding sites and can enter the cells through similar transport pathways (Verbost et al, 1987(Verbost et al, , 1989Spry and Wood, 1985;Rainbow and Blackmore, 2001). Similarly, waterborne Ca 2+ has a marked protective effect against waterborne Cd 2+ toxicity to brook trout (Carrol et al, 1979), tilapia (Pratap et al, 1989;Pratap and Wendelaar Bonga, 1993) and rainbow trout (Hollis et al, 2000;Hansen et al, 2002;Baldisserotto et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Rogers et al (2003) indicated that inhibitory effects of Pb 2+ on gill Na + /K + -ATPase might be connected with the disturbance of the ion homeostasis rather than membrane rupture, respiratory failure or acid-base disturbance. On the other hand, increases in ATPase activities could be related to developing resistance against to Pb 2+ , changes in water ion levels or compensation mechanisms (Flik et al, 1993 (Monserrat et al, 2007 (Roger et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Pb 2+ is released to the environment from various sources such as mining, smelting, coal burning, cement manufacturing, and gasoline (WHO, 1995). Studies showed that Pb 2+ was an antagonist for Ca 2+ in fish (Richards and Playle, 1998;Rogers et al, 2003Rogers et al, , 2005. Chronic exposure of fish to Pb 2+ caused the disruption in Ca 2+ homeostasis and neurological abnormalities (Davies et al, 1976;Mager et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Doğan¹,

Atli²,

Canli³

2015

Turk. J. Fish. Aquat. Sci.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Untitled

Doğan¹,

Atli²,

Canli³

2015

Turk. J. Fish. Aquat. Sci.

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“…Haematological indices like RBC count, concentration of haemogloblim and PCV have been reported to indicate secondary responses of an organism to pollutants (Rogers et al, 2003;Akinrotimi et al, 2012c). The MCV, MCH, and MCHC increased considerably in all treatment compared to the control.…”

Section: Journal Of Fisheriessciencescom George Adi Et Al 11(3): 0mentioning

confidence: 99%

Haematological Changes in African Catfish (Clarias Gariepinus)Exposed to Mixture of Atrazine and Metolachlor in the Laboratory

Adi¹,

Akinrotimi²,

Uk³

2017

fisheries-aqua

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Abstract:Seventy Two (72) male and female African catfish (Clarias gariepinus) juveniles of mean length (10.74 ± 1.81 g) were exposed to different concentrations of atrazine and metolachlor (0.00 mg/1-control, 0.01, 0.02, 0.03, 0.04 and 0.05mg/1) for 14 days to determine its effect on haematological parameters of the fish. The results obtained indicated significant (P<0.05) reductions with increased concentrations of the chemical in haemoglobin (Hb), Red blood Cell (RBC), packed cell volume (PCV), lymphocytes, platelets and mean corpuscular volume (MCV). The white blood cell (WBC), neutrophils, monocytes, mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentrations (MCHC) in fish exposed to the pesticides were significantly (P<0.05) higher than that of the control. The data obtained from this work will contribute to the base line haematological parameters for use in monitoring health status of Clarias gariepinus in the wild and culture medium

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The derivation of effects threshold concentrations of lead for European freshwater ecosystems

Sprang

Nys

Blust

et al. 2016

Enviro Toxic and Chemistry

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The main objective of the present study was to derive ecologically relevant effect threshold concentrations of (dissolved) Pb for selected European Union (EU) freshwater rivers, using the 2008 EU Voluntary Risk Assessment Report as a starting point and more advanced methodologies than those used in the Voluntary Risk Assessment Report. This included 1) implementing more robust quality criteria for selecting chronic toxicity data; 2) the conversion of total to dissolved Pb concentrations using a combination of an empirical equation relating inorganic Pb solubility and geochemical speciation modeling to account for effects of dissolved organic matter; 3) the use of bioavailability models for chronic toxicity for species belonging to 3 different trophic levels; and 4) the use of robust methods for large data set handling (such as species sensitivity distribution [SSD] analysis). The authors used published bioavailability models for an algal species (Pseudokirchneriella subcapitata) and a daphnid (Ceriodaphnia dubia) and developed a new model for the fathead minnow (Pimephales promelas). The research has shown that these models are also useful for, and reasonably accurate in, predicting chronic toxicity to other species, including a snail, a rotifer, midge larvae, and an aquatic plant (read-across). A comprehensive chronic toxicity data set for Pb was compiled, comprising 159 individual high-quality toxicity data for 25 different species. By applying the total dissolved conversion and the bioavailability models, normalized toxicity values were obtained, which were then entered into a SSD analysis. Based on the parametric best-fitting SSDs, the authors calculated that ecological threshold concentrations of Pb protecting 95% of freshwater species for 7 selected European freshwater scenarios were between 6.3 μg dissolved Pb/L and 31.1 μg dissolved Pb/L.

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Ionoregulatory disruption as the acute toxic mechanism for lead in the rainbow trout (Oncorhynchus mykiss)

Cited by 157 publications

References 56 publications

Untitled

Untitled

Haematological Changes in African Catfish (Clarias Gariepinus)Exposed to Mixture of Atrazine and Metolachlor in the Laboratory

The derivation of effects threshold concentrations of lead for European freshwater ecosystems

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