Iris atrophy in patients with newly diagnosed multibacillary leprosy: at diagnosis, during and after completion of multidrug treatment

Daniel, Ebenezer; Rao, P S S; Ffytche, T. J.; Chacko, Shirley; Prasanth, Hannah Ranjee; Courtright, Paul

doi:10.1136/bjo.2006.107177

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…If iris atrophy develops into a full-thickness defect, it can alter the shape or position of the pupil causing changes such as polycoria or transillumination defects. 8 Although no patients in our series developed full-thickness iris defects, this is certainly an outcome to consider for cataract surgeons.…”

Section: Discussionmentioning

confidence: 77%

Iris Atrophy After Administration of Intracameral Dexycu in Routine Cataract Surgery: A Case Series

Bergman¹,

Thompson²,

Malouf³

et al. 2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Dexycu (Icon Bioscience INC, Newark, CA) is an FDAapproved single-dose, sustained release intracameral steroid designed to mitigate postoperative inflammation after cataract surgery as an alternative to topical steroid therapy. The purpose of this study was to look at longterm and adverse events associated with Dexycu use. Eighteen eyes from nine patients who underwent cataract surgery were included. Patients were followed for an average of 97 days (range 28-319 days) after surgery on the first eye. Thirteen eyes were treated with Dexycu, and the other five eyes were treated with standard postoperative anti-inflammatory drops. Four of the thirteen eyes receiving Dexycu developed clinically evident iris atrophy (30.7%). None of the five eyes treated with traditional anti-inflammatory drops developed iris atrophy. The Dexycu intraocular dexamethasone implant was designed to mitigate postoperative inflammation and reduce need for topical therapy but may be associated with other potential adverse effects that warrant consideration.

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Section: Discussionmentioning

confidence: 77%

Iris Atrophy After Administration of Intracameral Dexycu in Routine Cataract Surgery: A Case Series

Bergman¹,

Thompson²,

Malouf³

et al. 2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…22 Interestingly, the iris atrophy that developed in MB Indian patients during and after MDTwas significantly associated with intraocular pressures of <10 mm Hg. 21 However, not all studies have demonstrated low pressure among MB patients and both primary and secondary glaucomas occur.…”

Section: Uveal Disease (And Complicated Cataract)mentioning

confidence: 99%

“…Iris atrophy was shown to develop in about 3% of MB patients in India even after completion of MDT and microbiologic cure and in this population it was associated with baseline keratic precipitates. 21 The role played by autonomic dysfunction in the pathogenesis of chronic uveitis is far from clear. In addition to miotic and poorly reacting pupils, low intraocular pressures have been documented and it is hypothesized that these could be due to autonomic dysfunction, caused by some unproven mechanism.…”

Section: Uveal Disease (And Complicated Cataract)mentioning

confidence: 99%

A Overview of Ocular Leprosy After 2 Decades of Multidrug Therapy

Lewallen

Courtright²

2007

International Ophthalmology Clinics

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“…Hal tersebut diduga terjadi karena perubahan permukaan iris tetap berlanjut dan berkaitan dengan adanya presipitasi keratik. 21…”

Section: Kelainan Pada Badan Siliaris Dan Irisunclassified

Kelainan Mata Pada Pasien Kusta

Sari¹

2019

MDVI

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ABSTRAKKeterlibatan intraokular paling sering terjadi pada kusta lepromatosa, dan tidak pernah pada kusta tuberkuloid. Tanda kelainan intraokular juga tidak umum didapati pada empat atau lima tahun pertama perjalanan penyakit. Kelainan mata pada kusta terjadi akibat kerusakan saraf dan invasi basil secara langsung. Komplikasi mata akibat kusta hanya terjadi pada segmen anterior dan adneksa mata. Lesi yang berpotensi menyebabkan kebutaan pada pasien kusta adalah lagoftalmus, hipoestesia kornea, iritis, skleritis dan atrofi iris. Riwayat atau sedang mengalami reaksi kusta tipe II dengan atau tanpa iritis, bercak di pipi atau infiltrasi difus di kulit wajah, pasien yang memiliki kecacatan tingkat I-II atau hanya pada mata, dan adanya penyakit penyerta, misalnya diabetes melitus atau glaukoma juga menjadi faktor risiko terjadinya kebutaan pada pasien kusta. Komplikasi mata juga sering ditemukan pada pasien kusta yang baru terdiagnosis dan yang sedang menjalani pengobatan. Deteksi dini, pengobatan yang efektif dan pengendalian reaksi yang tepat penting untuk menurunkan komplikasi mata pada pasien kusta.Kata kunci: kusta, kelainan mata, prevalensi, deteksi, pengobatan, pencegahan OCULAR ABNORMALITIES IN LEPROSY PATIENT ABSTRACTOcular involvement most commonly found in lepromatous leprosy and never in cases of tuberculoid leprosy. Signs of intraocular abnormality are not commonly found in the first four or five-years course of the disease. In 50% untreated multibacillary leprosy patients ocular lesions will appear at the end of the first decade. Ocular abnormalities in leprosy occurs due to nerve damage and direct invasion of bacilli. This complications due to leprosy occur only in the anterior segment and adnexa. Lesions that could potentially cause blindness in leprosy patients is lagophthalmus, corneal hypoaesthesia, iritis, scleritis and iris atrophy. A history or current episode of type II leprosy reaction with or without iritis, spots on the cheek or diffuse infiltration in the skin, patients who have a disability I-II level or only in the eye, and the presence of comorbidities such as diabetes mellitus or glaucoma is also risk factors of blindness in leprosy. Ocular complications are also commonly found in newly diagnosed leprosy patient and those undergoing treatment. Early detection, effective treatment and proper reaction management is important to reduce ocular complications in leprosy patients.

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Iris atrophy in patients with newly diagnosed multibacillary leprosy: at diagnosis, during and after completion of multidrug treatment

Cited by 13 publications

References 9 publications

Iris Atrophy After Administration of Intracameral Dexycu in Routine Cataract Surgery: A Case Series

Iris Atrophy After Administration of Intracameral Dexycu in Routine Cataract Surgery: A Case Series

A Overview of Ocular Leprosy After 2 Decades of Multidrug Therapy

Kelainan Mata Pada Pasien Kusta

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