Iron deficiency and thrombocytosis

Holbro, Andreas; Volken, Thomas; Buser, Andreas; Sigle, Jörg; Halter, Joerg; Passweg, Jakob; Thewis, André; Infanti, Laura

doi:10.1111/vox.12454

Cited by 18 publications

(9 citation statements)

References 13 publications

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“…The results of our work showed that a considerable number of IDA patients associated with increased platelet counts, which was consistent with the previous report [5]. Count of platelets in normal human is in a stable range and in a dynamic balance.…”

Section: Discussionsupporting

confidence: 93%

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Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis

et al. 2018

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Section: Discussionsupporting

confidence: 93%

“…Tubulin is the main component of microtubules, and commonly there are three types of the protein, αtubulin, β-tubulin and γ-tubulin [5]. The former two are the main tubulins belonging to spherical molecule.…”

Section: Molecular Biology Of Tubulinmentioning

confidence: 99%

Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis

et al. 2018

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“…They also observed a weak but statistically significant inverse correlation (r=-0.25, p<0.01) between hemoglobin levels and platelet counts among all patients with microcytic anemia. On the other hand, Holbro et al [21] found that the platelet counts did not show significant association to the cause of anemia. However, correlation analysis revealed that platelet counts had significantly be it weak correlation to the degree of anemia irrespective of the etiology.…”

Section: Discussionmentioning

confidence: 93%

Relationship between platelet counts, mean platelet volume, platecrit and Beta Thalassemia Carriers

Akbayram

Örkmez

2020

Journal of Contemporary Medicine

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Aim: β-thalassemia carriers (BTC) is generally asymptomatic; however, in clinical practice, there is hypochromic microcytic mild anemia caused by a hereditary reduction in beta globin synthesis. In the literature, there is also some information about platelet indices in BTC. The aim of this study was to evaluate platelet indices in children with BTC. In addition, we compared platelet indices between anemia (Hb<11 g/dl) and non-anemia BTC (Hb ≥11 g/dl). Material and Method: A cross sectional study included a total of 153 subjects aged 1-16 years were recruited from Gaziantep University Hospital outpatient clinics electronic database. Results: Platelet counts were normal in 90 patients with BTC. Thrombocytosis and thrombocytopenia were detected in 59 (38.5%) and four (2.6%) patients, respectively. This study group was divided into two groups as group 1, cases<11 g/dl (n=86), and group 2, cases≥11g/dl (n=67) according to the hemoglobin levels. The children with the group 1 had significantly higher mean levels of platelet counts and platecrit than those with group 2 (p<0.05). In the logistic regression test, linear correlation between platelet counts and platecrit (r=0.94, p<0.01) was observed, whereas there were inverse correlations between platelet counts and age (r=-0.32, p<0.01), mean platelet volume (r=-0.18, p<0.05), hemoglobin (r =-0.18, p<0.05). Conclusion: We found that both thrombocytosis and thrombocytopenia may occur in BTC. Herein we also found significantly elevated platelet counts in BTC with anemia.

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“…In studies conducted in humans, the relationship between iron deficiency and platelets has been demonstrated. However, its mechanism has not yet been fully understood (7,16). The fact that the EPO level in dogs with iron deficiency in our study was higher than it was in dogs with a normal serum iron level (P = 0.027, Fig.…”

Section: Resultsmentioning

confidence: 99%

Relationship between anemia, iron deficiency, and platelet production in dogs

Matur¹,

Ekiz²,

Erek³

et al. 2019

Medycyna Weterynaryjna

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Platelet production increases in anemic people. In particular, iron deficiency causes reactive thrombocytosis in such patients. Although anemia and iron deficiency are frequently seen in dogs, there are no published studies on this subject. The aim of the present study was to investigate the relationship between anemia, iron deficiency, and platelet production in dogs. A total of 81 dogs brought to the university animal hospital with signs of anemia were used. Haemogram parameters, serum iron (Fe), erythropoietin (EPO), and thrombopoietin (TPO) levels, as well as total iron binding capacity (TIBC), were measured. Transferrin saturation (TSAT) ratios were calculated. The animals were categorized as anemic or non-anemic, mildly anemic or moderately/ severely anemic, and having iron deficiency or no iron deficiency according to haemogram parameters and the serum Fe level. A high platelet number was observed in dogs with mild anemia. Dogs with mild anemia also had higher serum EPO levels than dogs with moderate/severe anemia (P = 0.047). Iron deficiency was detected in 31 dogs. The platelet number was higher in dogs with iron deficiency (P = 0.004). It was also observed that dogs with iron deficiency had higher serum EPO levels (P = 0.027) and lower TPO levels (P = 0.025) than dogs without iron deficiency. In conclusion, it can be said that mild anemia and iron deficiency cause thrombocytosis in dogs. The increased serum EPO levels, both in dogs with mild anemia and those with iron deficiency, suggest that the increase in platelet production is due to EPO. Nevertheless, there is a need for further research to fully understand the underlying mechanism.

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Iron deficiency and thrombocytosis

Cited by 18 publications

References 13 publications

Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis

Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis

Relationship between platelet counts, mean platelet volume, platecrit and Beta Thalassemia Carriers

Relationship between anemia, iron deficiency, and platelet production in dogs

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