Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis

Yung, Kam Chau; Zhang, Ze Wen; Yao, Wen; Qiu, Jin; Xu, Cheng; He, Chunqing; Xu, Xian Ru; Yin, Jun

doi:10.1080/10245332.2018.1439679

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…The results of our study are similar with the study of Yung et al and Kadikoylu et al where it was found that there exists a significant difference between IDA and platelet count. It was statistically significant between IDA and thrombocytosis and normal platelet count (p<0.01) 13,14 . A study showed mean red cell distribution width in IDA pregnant women 12.83 ± 1.03% in contrast with our study there was a negative correlation between Hb and RDW but a negative correlation between haemoglobin level and platelet count i.e.…”

Section: Discussionmentioning

confidence: 86%

Relationship Between Red Blood Cell and Platelet Indices in Iron Deficiency Anemia

Rabbani

Farooq

Naeem

et al. 2021

PAFMJ

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Objective: To find out the correlation between the red blood cell and platelet indices in patients presenting with iron deficiency anemia at a tertiary care hospital of Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Department of Hematology, Combined Military Hospital Lahore, from Sep 2018 to Mar 2019. Methodology: The patients of age 1-70 years of either gender presenting with IDA were included in the study. The blood sample of patients were sent to laboratory to assess the red blood cell and platelet indices. SPSS-23 was used to analyze data. Results: Two hundred and seven patients fulfilling the inclusion criteria were included in this study. The mean age was 25.6 ±17.8years. Correlation was weak and insignificant between haemoglobin and packed cell volume (r=-0.385**, p<0.01), haemoglobin and mean cell volume (r=-0.225**, p<0.01), packed cell volume and mean cell haemoglobin (r =0.263**, p<0.01), & mean cell haemoglobin and mean platelet volume (r=0.143*, p<0.05). Correlation was moderate and significant between platelet distribution width and mean platelet volume (r=0.511**) & platelet distribution width and platelet large cell ratio (0.502**, p<0.01). Correlation was strong between mean platelet volume and platelet large cell ratio (r=0.759**, p<0.01). Conclusion: In conclusion, there was significant relation between red blood cell and platelets indices in iron deficiency anemia. Furthermore, haemoglobin and packed cell volume are weekly correlated, platelet distribution width and mean platelet volume are moderately correlated and mean platelet volume and platelet large cell ratio are strongly correlated.

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Section: Discussionmentioning

confidence: 86%

Relationship Between Red Blood Cell and Platelet Indices in Iron Deficiency Anemia

Rabbani

Farooq

Naeem

et al. 2021

PAFMJ

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“…54 If we consider only absolute iron deficiency (i.e., excluding iron deficiency related to inflammation, see section 3.1.2), reactive thrombocytosis has been observed at the following frequencies: 13% in a study of 615 subjects by Kuku et al, 55 28% in 86 women by Kadikoylu et al, 56 and almost 33% in a large population of 36 327 IDA patients by Song et al 57 As mentioned above, the main mechanism whereby absolute iron deficiency favors thrombocytosis could be a shift of MEPs toward MkPs at the expense of ErPs. 23 It has also been reported that thrombocytosis in IDA could involve a downregulation of tubulin, which is one of the main components of the platelet cytoskeleton, 58 but this may be a consequence rather than a causative factor. Estimates of the thrombotic risk in the event of thrombocytosis related to absolute iron deficiency differ greatly: no cases of thrombosis were recorded by Kuku et al, 55 whereas thrombotic complications were observed by Song et al in 16% of IDA patients with thrombocytosis, compared with 8% in IDA without thrombocytosis.…”

Section: Absolute Iron Deficiencymentioning

confidence: 99%

Iron and platelets: A subtle, under‐recognized relationship

et al. 2021

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“…According to the World Health Organization guidelines, the persistent diagnosis of essential thrombocythemia requires a platelet count of ≥450,000/μL in patients with thrombocytosis, and it should be determined whether thrombocytosis is primary or secondary. The criteria of the World Health Organization are often used for diagnosis 6 .…”

Section: Introductionmentioning

confidence: 99%

Thrombocytosis in children

Babacan

Şenol

2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: We aimed to investigate the frequency and causes of thrombocytosis in patients admitted to the Department of Pediatric Hematology and Oncology of Elazig Fethi Sekin City Hospital, Elazig, Turkey. METHODS: Between 2019 and 2021, the laboratory parameters of 2,500 patients admitted to the Hematology Department were studied. During this examination, 319 (12.76%) patients were found to have thrombocytosis. Demographic characteristics (age and gender), hematologic parameters (hemoglobin, white blood cells, and platelets), and ultimate diagnoses ot the cases were recorded from their files. RESULTS: Of these 319 patients with thrombocytosis, 197 (1.8%) were male and 122 (38.2%) were female, and the mean age was 72.0±69.0 (1–216) months. The median platelet count of the patients was 590.43±280.12/μL (450,000–750,000). The most common cause of secondary thrombocytosis was infection, accounting for 37.9% of all patients. Other common causes were sickle cell anemia (21%), iron deficiency anemia (15.4%), colloid tissue disease (6.6%), hemolytic anemia (5.0%), splenectomy (4.5%), and other causes (9.7%). CONCLUSION: In our study, infections were the most common cause of thrombocytosis. In addition to infections, sickle cell anemia and iron deficiency anemia should also be considered in the differential diagnosis of thrombocytosis.

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Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis

Cited by 6 publications

References 7 publications

Relationship Between Red Blood Cell and Platelet Indices in Iron Deficiency Anemia

Relationship Between Red Blood Cell and Platelet Indices in Iron Deficiency Anemia

Iron and platelets: A subtle, under‐recognized relationship

Thrombocytosis in children

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