Iron Deficiency as a Risk Factor for First Febrile Seizure

Abstract

Estimation of Iron status in children with first febrile seizure (FFS). Iron status was evaluated by including Hemoglobin, Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Serum ferritin. MATERIALS AND METHODS: Study was conducted all children with first febrile seizures and febrile illnesses (FI) in Pediatrics Intensive Care Unit and Pediatrics Wards of Sri Adichunchanagiri Institute of Medical Sciences, B.G. Nagara from January 2010 to June 2011. The blood samples from the 50 children comprising the cases and 50 children comprising the controls constituted the material for the study. RESULTS : In the present study 58% cases were diagnosed as Iron Deficiency Anemia (IDA) with Febrile Seizure (FS); 18% controls were diagnosed as IDA with Febrile Illness. IDA was more frequent among children with FS than those with febrile illness alone. The result suggests that IDA may be a risk factor for FFS. Screening for IDA should be considered in children with FFS. CONCLUSION: Iron Deficiency Anemia is associated with the severity of a febrile illness, and more severe cases could be more likely to get seizures.

Low Serum Ferritin is a Risk for Febrile Convulsion in Children

“…HB, HCT, MCH, mean serum ferritin and serum iron, were significantly low in the febrile convulsion group as compared to control group (Table 2). Similar results found in different studies Ahmed 9 and Majumdhar et al 10 analyzed for Iron deficiency as a risk factor for febrile convulsion, by biochemical and hematological investigations. In Majumdhar R et al 10 study mean Hb, MCV and MCH was 8.92g%, 67.03 fl, 30.66 pg respectively which was significantly low in cases compared to control.…”

Iron Deficiency Anemia in Children with Febrile Convulsions: A Case–control Study at Sohag University Hospital

“…Average mean of MCH in case group was statistically significantly lower than normal (30.96±3.58 gms), while in control group it was within normal (32.68±2.32 gms). It came in agreement with Khanna et al (12) , Jang et al (13) , Tripathy et al (15) , and Majumdhar et al (19) .…”

“…This was quite similar to result of studies of Khanna et al (12) and Noorbakhsh (17) . While in Surani et al (14) mean MCV was (8.87 g/dl) and in Majumdhar et al (19) it was (67.03 fl).…”

“…This came in consistence with Tripathy et al (15) and Vikash et al (18) . While in Surani et al (14) Hb level was (8.87 g/dl) and in Majumdhar et al (19) mean it was (8.92 g/dl). In contrast to our results Noorbakhsh (17) found that mean Hb level was within normal (11.6±0.79 g/dl) and also it was around 11 g/dl in Hadi et al (20) .…”

Correlation of serum iron and serum calcium levels in children with febrile seizures

“…URTI, as in present study is also the most common etiology of fever in other studies too. Study by Majumdhar et al 14 had URTI as the commonest cause with no statistical difference with control group. Sultan et al 18 found respiratory tract infections as the commonest cause (78% in cases).…”