Iron Deficiency in COPD Associates with Increased Pulmonary Artery Pressure Estimated by Echocardiography

Plesner, Louis Lind; Schoos, Mikkel Malby; Dalsgaard, Morten; Goetze, Jens P.; Kjøller, Erik; Vestbo, Jørgen; Iversen, Kasper

doi:10.1016/j.hlc.2016.04.020

Cited by 24 publications

(26 citation statements)

References 13 publications

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“…Interestingly, even though mechanical obstruction is the main driver of pre-capillary disease in these individuals, vascular remodelling occurs as well, if the mechanical obstruction persists for a longer time [21]. Pre-capillary PH is also frequently found in patients suffering from chronic hypoxia due to pulmonary diseases, such as in individuals with severe COPD [22]. In these patients, mPAP and PVR are typically mild to moderately elevated, whereas patients with IPAH or CTEPH may present with distinctly higher mPAP and pulmonary vascular resistance (PVR).…”

Section: Pulmonary Hypertensionmentioning

confidence: 99%

Anaemia, iron homeostasis and pulmonary hypertension: a review

et al. 2020

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Anaemia is a highly prevalent condition, which negatively impacts on patients' cardiovascular performance and quality of life. Anaemia is mainly caused by disturbances of iron homeostasis. While absolute iron deficiency mostly as a consequence of chronic blood loss or insufficient dietary iron absorption results in the emergence of iron deficiency anaemia, inflammation-driven iron retention in innate immune cells and blockade of iron absorption leads to the development of anaemia of chronic disease. Both, iron deficiency and anaemia have been linked to the clinical course of pulmonary hypertension. Various mechanistic links between iron homeostasis, anaemia, and pulmonary hypertension have been described and current treatment guidelines suggest regular iron status assessment and the implementation of iron supplementation strategies in these patients. The pathophysiology, diagnostic assessment as well as current and future treatment options concerning iron deficiency with or without anaemia in individuals suffering from pulmonary hypertension are discussed within this review.

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Section: Pulmonary Hypertensionmentioning

confidence: 99%

Anaemia, iron homeostasis and pulmonary hypertension: a review

et al. 2020

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“…NAID is observed in 40 to 50% of patients with COPD (18,92). However, existing strategies to define ID in patients with COPD may be confounded by pseudo increases in inflammation-associated ferritin (93), signifying that ID may be underdiagnosed in COPD. In addition, ID could be particularly deleterious in patients with COPD with extrapulmonary manifestations such as pulmonary hypertension (PH).…”

Section: Prevalence Of Anemia and Id In Copdmentioning

confidence: 99%

The “Iron”-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease

Cloonan

Mumby²,

Adcock³

et al. 2017

Am J Respir Crit Care Med

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“…Importantly, anemia might reflect iron deficiency, which has been linked to the development of pulmonary arterial hypertension14 and presence of chronic inflammation, which is associated with frailty 15. Concentrations of hemoglobin and hematocrit have been shown to provide prognostic information in different populations of COPD patients,16–25 but in many of these studies patients with diseases associated with chronic anemia were excluded 12.…”

Section: Introductionmentioning

confidence: 99%

Association between hemoglobin and prognosis in patients admitted to hospital for COPD

Toft-Petersen¹,

Torp‐Pedersen²,

Weinreich³

et al. 2016

COPD

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Low concentrations of hemoglobin have previously been demonstrated in many patients with COPD. There is evidence of anemia as a prognostic factor in acute exacerbations, but the detailed relationship between concentrations of hemoglobin and mortality is not known. A register-based cohort of patients admitted for the first time to Danish hospitals for acute exacerbations of COPD from 2007 through 2012 was established. Age, sex, comorbidities, medication, renal function, and concentrations of hemoglobin were retrieved. Sex-specific survival analyses were fitted for different rounded concentrations of hemoglobin. The cohort encompassed 6,969 patients. Hemoglobin below 130 g/L was present in 39% of males and below 120 g/L in 24% of females. The in-hospital mortality rates for patients with hemoglobin below or above these limits were 11.6% and 5.4%, respectively. After discharge, compared to hemoglobin 130 g/L, the hazard ratio (HR) for males with hemoglobin 120 g/L was 1.45 (95% confidence interval [CI] 1.22–1.73), adjusted HR 1.37 (95% CI 1.15–1.64). Compared to hemoglobin 120 g/L, the HR for females with hemoglobin 110 g/L was 1.4 (95% CI 1.17–1.68), adjusted HR 1.28 (95% CI 1.06–1.53). In conclusion, low concentrations of hemoglobin are frequent in COPD patients with acute exacerbations, and predict long-term mortality.

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Iron Deficiency in COPD Associates with Increased Pulmonary Artery Pressure Estimated by Echocardiography

Cited by 24 publications

References 13 publications

Anaemia, iron homeostasis and pulmonary hypertension: a review

Anaemia, iron homeostasis and pulmonary hypertension: a review

The “Iron”-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease

Association between hemoglobin and prognosis in patients admitted to hospital for COPD

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