Iron in ferrous gluconate and Ascofer®

Gozdyra, R.; Dubiel, S. M.; Cieślak, J.

doi:10.1088/1742-6596/217/1/012146

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…Apart from main component additional components related to the high spin ferric compound were observed in the Mössbauer spectra. Ferric ions accompanying ferrous iron compound contained in dietary supplements were also observed by other authors [3,[5][6][7][8]. All observed ferric components have similar hyperfine parameters, but their content is different in investigated medicaments.…”

Section: Resultssupporting

confidence: 78%

Stability of Ferrous Fumarate in Medicaments for Women: Application of Mössbauer Spectroscopy

Kądziołka-Gaweł

Wojtyniak

2016

Acta Phys. Pol. A

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Determination of the iron state (Fe 2+ or Fe 3+ ) and content of iron in commercial pharmaceutical products containing ferrous fumarate FeC4H2O4 was made by the Mössbauer spectroscopy and X-ray fluorescence method. Also, influence of thermal treatment on stability of ferrous fumarate in selected medicaments has been investigated. The investigated samples were annealed in definite temperature: 373, 473, and 573 K for 5 h. Room temperature Mössbauer spectra of initial samples gave clear evidence that two phases of iron were presented. The major component was connected with ferrous fumarate with a contribution from ≈85% to ≈50%, depending on investigated medicaments. Ferrous fumarate was stable up to annealing temperature 473 K. Above this temperature significant oxidation of Fe 2+ to Fe 3+ was observed.

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Section: Resultssupporting

confidence: 78%

Stability of Ferrous Fumarate in Medicaments for Women: Application of Mössbauer Spectroscopy

Kądziołka-Gaweł

Wojtyniak

2016

Acta Phys. Pol. A

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“…Both IS and QS for the ferric ion are overlapped with ferrous-LS. However, the identification of the spin state and valence state of the minor phase in ferrous gluconate is unclear, yet [ 10 , 11 ]. The surface integral of the fitted spectrum is applied to the composition of the sample.…”

Section: Resultsmentioning

confidence: 99%

“…We may suppose that the doublet with δ and Δ E Q values of 0.12 and 0.9 mm/s is attributed to a ferric phase in ferrous gluconate, according to a certificate analysis. This results in ferrous gluconate oxidation and the formation of ferric gluconate [ 10 , 11 ]. The doublet with δ and Δ E Q values of 1.09 and 3.06 mm/s is attributed to ferrous gluconate.…”

Section: Resultsmentioning

confidence: 99%

Analyses of Ferrous and Ferric State in Dynabi_TabUsing Mössbauer Spectroscopy

Uhm

Lim

Choi

2017

International Journal of Analytical Chemistry

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Antianemic medicament ferrous gluconate, ferrous fumarate, and a Dynabi tablet with a basic iron bearing ingredient were studied with the use of Mössbauer spectroscopy. Room temperature spectra of ferrous gluconate gave clear evidence that the two phases of iron were present: ferrous (Fe2+) as a major one with a contribution at and above 91 a.u.% and ferric (Fe3+) whose contribution was found to be ~9 a.u.%. In the case of ferrous fumarate, a single phase was measured corresponding to ferrous (Fe2+) state. A Dynabi tablet consists of ferrous fumarate and ferrous fumarate. The ferric phase in ferrous gluconate is able to be reached about ~3.6 a.u.% in a tablet.

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