Iron Oxide Nanoparticles for Tissue Repair and Regeneration

Abstract

Iron oxides are naturally occurring compounds, and several methods have been developed for generating iron oxide nanoparticles (IONPs) with a focus on precisely modulating their size and physicochemical properties. Facile synthesis approaches, narrow size distribution, ease of surface modification, tunable magnetic properties, and size-dependent elimination from blood circulation, make IONPs attractive for use in different biomedical applications. This review describes the use of IONPs for application in tissue repair and regeneration with a focus on neural and musculoskeletal tissues.

Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine

“…It has also been reported that nanomaterials with POD-like activity can catalyze RXS generation for chemo-driven antibacterial therapy, 340,341 with iron oxide NPs (IONPs) as a typical example of these chemo-driven therapeutic nanomaterials. 341 Due to their POD-like ability, IONPs can react with H 2 O 2 to promote OH production for effective bactericidal effects. Meanwhile, novel semiconductors with different energy bands can also trigger RXS generation under light irradiation, such as in the PDT therapeutic modality.…”

Ionotropic Gelation-Based Synthesis of Chitosan-Metal Hybrid Nanoparticles Showing Combined Antimicrobial and Tissue Regenerative Activities

“…Furthermore, previous studies have reported that topically applied iron chelators and their novel therapeutic agents are able to improve the wound healing [32]. Recently, the antibacterial properties of these NPs have been studied in some depth [33,34], such as their application in regenerative medicine and tissue engineering [35], above all for neural and musculoskeletal tissues [36]. Thus, an interesting approach would be the incorporation of Fe 3 O 4 NPs within CS polymeric NPs in order to combine their individual regenerative and antimicrobial properties in one unique element.…”