Iron phosphide nanoparticles as a pH-responsive <i>T</i><sub>1</sub> contrast agent for magnetic resonance tumor imaging

Qiu, Yuan; Lin, Wei‐Wen; Wang, Lili; Li, Rui; Xie, Jiangao; Chen, Xin; Yang, Funmei; Huang, Guoming; Yang, Huanghao

doi:10.1039/c9ra06886d

Cited by 4 publications

(15 citation statements)

References 28 publications

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“…The r 1 values are higher than those of other MRI contrast agents (FeP, Fe@MSNs, MnFe-LDH) and commercially available Gd contrast agents, such as Gd-DTPA and Gd-DOTA. [43][44][45][46][47] On the other hand, the r 2 images showed a clear Fe(III)-concentration dependent change from bright to dark, and the r 2 value was calculated to be 26.59 mM À1 s À1 , suggesting good sensitivity as a T 2 MRI contrast agent. The r 2 /r 1 ratio is estimated to be $2.7 in the range of 2-10, [48][49][50] indicating the simultaneous combination of the T 1 and T 2 contrast effects.…”

Section: Mri Performance Of Dual-fe/omcmentioning

confidence: 98%

In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery

Zhang

et al. 2020

Nanoscale Adv.

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Section: Mri Performance Of Dual-fe/omcmentioning

confidence: 98%

In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery

Zhang

et al. 2020

Nanoscale Adv.

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“…FeP nanoparticles can product significantly enhanced T 1 magnetic resonance signals by releasing paramagnetic Fe ions under acidic TME stimulation. [ 6 ] Due to the excellent loading performance and good degradability of metal phosphate, the combination of metal phosphate nanomaterials and paramagnetic ions can obtain a metal phosphate‐based MRI contrast agent in response to pH stimulation. Moreover, Kataoka's group reported that confining Mn 2+ within pH‐sensitive PEG‐CaP NPs (PEGMnCaP) could achieve rapid amplification of MR signals in response to acidic pH value.…”

Section: Metal‐p Nms For Tumor Diagnosismentioning

confidence: 99%

“…[ 19 ] The excellent optical, magnetic, and catalytic properties make Metal‐P NMs can be used as multifunctional diagnostic (photoacoustic imaging (PAI), fluorescent imaging (FI), magnetic resonance imaging (MRI), and nuclear imaging) and therapeutic (photothermal therapy (PTT), chemodynamic therapy (CDT), photodynamic therapy (PDT), and immunotherapy) agents for tumor theranostics. [ 5–19 ] Moreover, Metal‐P NMs are also suitable to be nanocarriers for delivering drugs owing to their degradable properties. [ 12 ] As a good medicine carrier, Metal‐P NMs can be loaded on chemotherapy drugs, photosensitizers, sonosensitizers, Fenton agents, genes, proteins, and various imaging contrast agents to achieve the integration of multimodal imaging and therapies.…”

Section: Introductionmentioning

confidence: 99%

Tumor Diagnosis and Therapy Mediated by Metal Phosphorus‐Based Nanomaterials

et al. 2021

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to their unique physical and chemical properties. [2] Therefore, to improve the efficacy of early diagnosis and cure rate, many types of inorganic nanomaterials have been prepared for tumor therapy, such as elemental substances (Au, Ag, Pt, etc.), [3a-c] chemical compounds (carbon-, silic-, nitrogen-, phosphorus-based nanomaterials, etc), [3d-f ] metal organic frameworks, and so on. [3g,h] Among above inorganic nanoterials, phosphorus-based nanomaterials have broad application prospects in the field of biomedicine because phosphorus is one of the crucial component elements in our body and it could maintain vital activities in different aspects: [4] 1) Phosphorus is one of the basic elements in protein and phospholipid and it is necessary to maintain the integrity of cell membranes and perform cell functions. 2) Phosphorus is also a necessary component of phosphate in body fluids and it could regulate the pH balance and energy metabolism. 3) Phosphorus is one of the basic elements of our bone for supporting our body. Among the phosphorus-based nanomaterials, metal phosphorus-based nanomaterials (Metal-P NMs) have been widely explored and studied in cancer diagnosis and therapy due to their unique merits, such as excellent optical absorption, inherent magnetic properties, and biodegradable properties.Metal-P NMs mainly include metal phosphide nanomaterials (e.g., ferrous phosphide (Fe 2 P), [5] iron phosphide (FeP), [6] cuprous phosphide (Cu 3 P), [7] trinickel monophosphide (Ni 3 P), [8] dicobalt phosphide (Co 2 P), [9a-c] cobalt phosphides (CoP), [9d,e] cadmium phosphide (Cd 3 P 2 ), [10] and indium phosphide (InP) [11] ), metal phosphate nanomaterials (e.g., calcium phosphate (CaP), [12] calcium bisphosphonate (CaBP), [13] manganese phosphate (MnP), [14,50] zirconium phosphate (ZrP), [15] magnesium phosphate (MgP), [16] gadolinium phosphate (GdPO 4 ), [17] and copper hydroxyphosphate (Cu 2 (OH)PO 4 ) [18] ), and metalblack phosphorus (Metal-BP) nanocomposite. [19] The excellent optical, magnetic, and catalytic properties make Metal-P NMs can be used as multifunctional diagnostic (photoacoustic imaging (PAI), fluorescent imaging (FI), magnetic resonance imaging (MRI), and nuclear imaging) and therapeutic (photothermal therapy (PTT), chemodynamic therapy (CDT), photodynamic therapy (PDT), and immunotherapy) agents for tumor theranostics. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Moreover, Metal-P NMs are also suitable to Metal phosphorus-based nanomaterials (Metal-P NMs) including metal phosphate nanomaterials, metal phosphide nanomaterials, and metal-black phosphorus (Metal-BP) nanocomposite are widely used in the field of biomedicine owing to their excellent physical and chemical properties, biocompatibility, and biodegradability. In recent years, metal phosphate nanomaterials and Metal-BP nanocomposite acted as medicine delivery system have made breakthroughs in tumor diagnosis including magnetic resonance imaging, fluorescence imaging, photoacoustic imaging, nuclear imaging, and therapies ...

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“…For instance, Qiu et al 65 synthesized novel FeP NPs with a pH-activatable T 1 -weighted MR signal. In the presence of an acidic microenvironment (pH = 5.5), nearly 60% of Fe 3+ ions were extracted, which is almost ten-fold that under neutral conditions (pH = 7.4).…”

Section: Ion Extractionmentioning

confidence: 99%

“…Hence, some designs based on valance changes of these diamagnetic ions have emerged. [61][62][63][64][65][66][67] For instance, Liu et al 68 (G) The T 1 -based assay for the detection of glucose in serum, urine, and saliva with different concentrations of glucose. Reproduced with permission.…”

Section: Valance Conversionmentioning

confidence: 99%

Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications

Jin

Yang

et al. 2021

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Magnetic resonance imaging (MRI) is a highly valuable diagnostic tool as it is a noninvasive technique that offers high spatial resolution. The use of contrast agents (CAs) can enhance the precision and specificity of MRI for disease diagnosis, but their imaging signals are "always on" regardless of whether they interact with target tissues or cells. Hence, a poor target-to-background signal ratio (TBR) is inevitably produced. In contrast, activatable CAs with high performance have been used to significantly improve the TBR, thus these CAs have also received extensive attention and undergone in-depth research. In this review, we summarized the recent advances in design strategies and principles of activatable MR CAs, including ion conversion, self-assembly, and disassembly. Additionally, we analyzed the advantages of these strategies in biomedical applications from in vitro biodetection to in vivo disease diagnosis compared to the outcomes of conventional MR CAs. Finally, we discussed the potential limitations, proposed solutions, and future perspectives of these activatable CAs. K E Y W O R D Sactivatable MR imaging, design strategies, target-to-background signal ratio, relaxivity, biomedical applications 1This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Iron phosphide nanoparticles as a pH-responsive T₁ contrast agent for magnetic resonance tumor imaging

Abstract: In this work, the potential of FeP nanoparticles as a pH-responsive T1 contrast agent was investigated.

Cited by 4 publications

References 28 publications

In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery

In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery

Tumor Diagnosis and Therapy Mediated by Metal Phosphorus‐Based Nanomaterials

Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications

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Iron phosphide nanoparticles as a pH-responsive T1 contrast agent for magnetic resonance tumor imaging

Abstract: In this work, the potential of FeP nanoparticles as a pH-responsive T1 contrast agent was investigated.

Cited by 4 publications

References 28 publications

In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery

In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery

Tumor Diagnosis and Therapy Mediated by Metal Phosphorus‐Based Nanomaterials

Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications

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Product

Resources

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Iron phosphide nanoparticles as a pH-responsive T₁ contrast agent for magnetic resonance tumor imaging