Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus

Misra, Gunjan; Bhatter, Surendra Kumar; Kumar, Ajai; Gupta, Varsha; Khan, M. Firoze

doi:10.3390/medsci4040022

Cited by 11 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in accordance with Kamalam, et al [3], Shetty et al [4], Saha et al [11], Kapoor et al [12] and Misra et al [13] Kamalam et al [3] found a significant increase in serum iron in poor glycemic controls as in comparision with found lower levels of TIBC and UIBC in diabetic patients as compared to the Healthy individuals. Misra et al [13] reported, significant difference between mean serum free iron and TIBC concentration between Group I (Healthy individuals) and Group III (T2DM patients with suboptimal glycemic control) (p < 0.05).…”

Section: Discussionsupporting

confidence: 92%

Relation of Iron, TIBC and Oxidative Stress with Glycosylated Haemoglobin in Diabetes Mellitus

Qureshi

Rai

2020

IJBcRR

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. Scientific evidences suggest that high iron storage may play a role in pathogenesis of type 2 diabetes. Excess iron accumulation induces organ damage due to the overproduction of ROS through Fenton reaction. Thus, the aim of this study was to find out the relation between serum iron, total iron binding capacity (TIBC) and oxidative stress (OS) with glycosylated haemoglobin (HbA1c) in type 2 diabetes mellitus patients. The study consisted of 90 subjects, which were divided into 3 different groups; Group 1 compromised of 30 healthy individuals, Group 2 included 30 T2DM patients with normal glycemic control and Group 3 included 30 T2DM patients with poor glycemic control. Blood samples were collected from the three groups and fasting plasma glucose (FPG), post-prandial plasma glucose (PPPG), HbA1c, Iron, TIBC, Hemoglobin (HB), Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels were analysed. We found, that mean levels of FPG, PPPG, HbA1c, Iron and MDA were significantly higher (p < 0.05) and mean levels of TIBC, SOD and CAT were significantly decreased (p < 0.05) in group 3 as compared to group 2 and group 1. There was no significant difference (p > 0.05) observed in iron, TIBC and Hb levels between group 1 and group 2. We found a significant positive correlation of Iron and MDA with HbA1c and significant negative correlation of TIBC, SOD and CAT with HbA1c in group 3. In our study we found significant positive correlation of HbA1c with MDA and iron that indicates poor glycemic control leads to increased glycation of haemoglobin and other heme containing proteins. It causes more release of iron that leading to production of oxidative stress and thereby it might plays significant role in early appearance of diabetic complications.

show abstract

Section: Discussionsupporting

confidence: 92%

Relation of Iron, TIBC and Oxidative Stress with Glycosylated Haemoglobin in Diabetes Mellitus

Qureshi

Rai

2020

IJBcRR

View full text Add to dashboard Cite

show abstract

“…Our results were consistent with the work done and results found by some other researchers. [16][17][18][19][20] A closer association is there in type 2 DM and iron profile and this is because an alteration in blood glucose metabolism can results in altered iron metabolism and so on.…”

Section: Discussionmentioning

confidence: 99%

Biochemical assessment of iron profile in type 2 diabetes patients.

Shah

Rehman

Khan

et al. 2020

TPMJ

View full text Add to dashboard Cite

Objectives: Iron profile is considered to be an important guide for improved health around the globe. An altered iron profile is a risk factor for numerous diseases. Extreme iron accretion in body results in damaging many cellular structures as well as in oxidative damage with many complications. Thus, iron profile must be considered in many ailments including DM. Study Design: Descriptive study. Setting: Department of Biochemistry, BMC Bannu and Department of Medicine, KGN Teaching Hospital Bannu-KPK. Period: January 2019 to June 2019. Material & Methods: 140 subjects were taken in this study, out of which 70 were suffering from type 2 diabetes and 70 were normal healthy controls. BMI was calculated by dividing body weight (Kg) to square of height (meters). The waist / hip circumference ratio was calculated by dividing the waist circumference (cm) to hip circumference (cm). Sphygmomanometer was used for blood pressure measurement. The serum iron, TIBC, UIBC, plasma glucose and HbA1c were measured by semi-auto analyzer. The serum ferritin was estimated by chemiluminescence method. The % transferrin saturation was calculated by formula serum iron (μg/dl) x 100/ TIBC (μg/dl). Result: The anthropometric parameters like weight, BMI, waist circumference, hip circumference, waist hip circumference ratio, systolic and diastolic blood pressure was statistically extremely significantly (p<0.001) increased in type 2 diabetes mellitus subjects as compared to healthy control subjects. The plasma fasting glucose, HbA1C, serum iron, % saturation and serum ferritin were statistically extremely significantly (p<0.001) increased and UIBC was statistically extremely significantly (p<0.001) decreased while TIBC and hemoglobin were statistically significantly (p<0.05) decreased in type 2 diabetes mellitus subjects as compared to healthy control subjects. Conclusion: Elevated iron and ferritin is a risk factor for diabetes and produce many complications. Proper management must be taken to remove the excess iron that can be very harmful to the body.”

show abstract

“…Elevated iron stores cause insulin resistance and possibly defective secretion of insulin. Patients with DM and elevated serum iron concentrations have higher glucose levels (Misra, Bhatter, Kumar, Gupta, & Khan, ).…”

Section: Discussionmentioning

confidence: 99%

“…These participants had a greater intake of total iron and heme iron in the form of meat consumption. Red meat, especially processed meat, concentrations have higher glucose levels (Misra, Bhatter, Kumar, Gupta, & Khan, 2016).…”

Section: Discussionmentioning

confidence: 99%

Dental iron precipitates in patients with Type 2 diabetes

Ortiz-Arrambide

Juárez-Ibarra

Malagon-Santiago

et al. 2018

Clinical & Exp Dental Res

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a frequent worldwide disease. There are currently more than 46 million people who suffer this disease in North America and the Caribbean. The objective of this study was to determine if there is an association between DM and the presence of iron precipitates (Fe 2+ ) in dental structure. The third molar was extracted for reasons that merit extraction from 40 individuals with and without DM to analyze dentin tissue. Horizontal and longitudinal slices of tooth samples were made and later stained with 10% potassium cyanoferrate. The samples were observed by optical microscope to identify basophilic elements. A nonparametric Spearman correlation was performed to find an association between the quantitative (gender, group, and dentinal tissue) and qualitative variables (gender). The Mann–Whitney U test was used to find differences in the means of the nonparametric variables in two different groups in relation to the P value (<0.05). Iron elements were found in the predentin and circumpulpal dentin areas, and the results obtained showed a statistically significant difference between dentin tissue from patients with diabetes and those without. Individuals with Type 2 DM are prone to present iron precipitates in predentin and circumpulpal dentin tissue. Few iron elements were found in dental organs of individuals without DM.

show abstract

Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus

Cited by 11 publications

References 33 publications

Relation of Iron, TIBC and Oxidative Stress with Glycosylated Haemoglobin in Diabetes Mellitus

Relation of Iron, TIBC and Oxidative Stress with Glycosylated Haemoglobin in Diabetes Mellitus

Biochemical assessment of iron profile in type 2 diabetes patients.

Dental iron precipitates in patients with Type 2 diabetes

Contact Info

Product

Resources

About