Iron status and itts relationship with lipid peroxidation in patients with acute myocardial infarction

Baykan, Merih; Çelik, Uğur; Örem, Asım; Malkoç, Meltem; Erdöl, Cevdet; Baykan, E C; Örem, Cihan; Karahan, Burhan

doi:10.2143/ac.56.5.2005687

Cited by 14 publications

(11 citation statements)

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“…Despite being a potent antioxidant, NAC may have prooxidant properties when contacting iron ions [11]. In fact, it has been demonstrated that patients suffering an AMI increase serum iron levels, inducing lipid peroxidation after the ischemic event [1]. Since the reaction between iron and NAC may yield free radicals in biological systems [10,11], it can be .…”

Section: Discussionmentioning

confidence: 99%

“…The DFX dose and regimen were chosen based on previous studies that have already employed this combination [17,18] and on the behavior of iron release post-AMI described in humans [1]. Cardiac function was assessed by echocardiography for 28 days, and an improvement could be seen only at the end of protocol for NAC/DFX treated rats, with a net improvement of 10 % in left ventricular ejection fraction and a substantial attenuation of systolic chamber dilation.…”

Section: Discussionmentioning

confidence: 99%

“…Acute myocardial injury associated to myocardial infarction (AMI) promotes the release of cellular contents, such as troponins, microRNA, and iron [1,2]. In this scenario, free radical generation and oxidative stress take place and may be caused both by inflammatory cells infiltrating the myocardium and by cardiomyocytes after the onset of necrosis [3].…”

Section: Introductionmentioning

confidence: 99%

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N-acetylcysteine Plus Deferoxamine Improves Cardiac Function in Wistar Rats After Non-reperfused Acute Myocardial Infarction

Phaelante

Rohde

Lopes

et al. 2015

J. of Cardiovasc. Trans. Res.

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The antioxidant N-acetycysteine can turn into a prooxidant molecule in presence of iron ions. Thus, our goal was to test if the association of N-acetylcysteine (NAC) and an iron chelator (deferoxamine--DFX) in a rodent model of acute myocardial infarction (AMI) improves cardiac function. Male Wistar rats were subjected to a SHAM surgery or AMI. The animals were randomized: vehicle, NAC (25 mg/kg for 28 days), DFX (40 mg/kg for 7 days), or NAC plus DFX (NAC plus DFX, respectively). Animals were killed 28 days after the AMI. Animals treated with NAC/DFX showed an increase in left ventricular ejection fraction at 28 days when compared with vehicle group (45.2 ± 10.9 % vs. 34.7 ± 8.7 %, p = 0.03). Antioxidant effect of NAC/DFX treatment decreased 4-hydroxynonenal when compared to AMI group (p = 0.06). In conclusion, we showed beneficial effect of NAC/DFX association in improving left ventricle function in an experimental AMI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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N-acetylcysteine Plus Deferoxamine Improves Cardiac Function in Wistar Rats After Non-reperfused Acute Myocardial Infarction

Phaelante

Rohde

Lopes

et al. 2015

J. of Cardiovasc. Trans. Res.

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“…MDA levels can change with time following an acute MI. Erythrocyte MDA levels in patients increase immediately during an acute MI, peak on day 1 post‐MI, and then decline to 57% of the peak value by day 45 post‐MI [31]. In the present study, the different treatments started at 60 days post‐MI, so we expected TBARS levels in the ramipril group to be as low as, or lower than, those in the MI group.…”

Section: Discussionmentioning

confidence: 79%

A proteomic study of the effects of ramipril on post‐infarction left ventricular remodelling in the rabbit

Chen

Lee

Hsu

et al. 2008

European J of Heart Fail

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Objectives: In this study, we used a proteomic approach to investigate the potential proteins regulated by ramipril in post-infarction left ventricular remodelling in the rabbit. Methods and results: Myocardial infarction (MI) was induced in male New Zealand White rabbits (2.5-3 kg) by ligation of the left anterior descending coronary artery. Two months later, the rabbits were either left untreated (MI group) or were treated daily for one month with 0.1 mg/kg wt of ramipril (ramipril group), then sacrificed. One month of ramipril treatment resulted in a significant improvement in the LV ejection fraction (LVEF) and a decrease in hydroxyproline content. The protein profiles of LV tissue showed that ramipril caused upregulation of glutathione peroxidase, superoxide dismutase (SOD), and heart-type fatty acid binding-protein (h-FABP) and downregulation of HSP27 and cyclophilin A. Ramipril treatment caused an increase in catalase, glutathione peroxidase, and SOD activity in the LV tissue. Oxidized glutathione levels and the GSSG/GSH ratio in the heart tissue were lower in the ramipril group than in the MI group. Conclusions: Ramipril increased antioxidative protein expression and enzyme activity, which could partly explain the role of ramipril in attenuating LV remodelling. In addition, the present study identifies several potential protein targets which may help to explain the mechanism by which ramipril exerts its effect in post-infarction LV remodelling in the rabbit.

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“…According to these studies, ferritin may act as a pro-oxidant. Iron donates an electron to promote the formation of reactive oxygen species via the Fenton reaction and this causes oxidation of LDL, a trigger for the development of atherosclerotic CAD 6,7. Inflammation is associated with an abnormality in the redox state in the vasculature.…”

Section: Introductionmentioning

confidence: 99%

Interaction between dyslipidaemia, oxidative stress and inflammatory response in patients with angiographically proven coronary artery disease

Tayal

Goswami

Tyagi

et al. 2012

Cardiovascular Journal of Africa

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IntroductionCoronary artery disease (CAD) is emerging as the biggest killer of the 21st century. A number of theories have been postulated to explain the aetiology of atherosclerosis. The present study attempts to elucidate the interaction, if any, between inflammation, oxidative stress and dyslipidaemia in CAD.MethodsA total of 753 patients undergoing angiography were evaluated and 476 were included in the study. The parameters studied included complete lipid profile, and apolipoprotein B, ferritin and nitric oxide (NO) levels. Statistical analysis was carried out to determine the interrelationship between these parameters and the best predictor of CAD risk. Cut-off points were determined from the receiver operating characteristics curves, and the specificity, sensitivity, positive predictive value, negative predictive value, odds ratio and confidence intervals were calculated.ResultsThe levels of the parameters studied increased with the stenotic state and a positive correlation was observed between ferritin, NO and apolipoprotein B. NO emerged as the most reliable predictor of CAD, with an area under the curve of 0.992 and sensitivity and specificity of 97 and 98%, respectively.ConclusionEnvironmental and genetic risk factors for CAD interact in a highly complex manner to initiate the atherosclerotic process. These risk factors should be considered mutually inclusive, not exclusive when devising pharmacological interventions, as multi-factorial risk management is the cornerstone of CAD management

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Iron status and itts relationship with lipid peroxidation in patients with acute myocardial infarction

Abstract: There was an association of higher iron status with increased lipid peroxidation in patients with myocardial infarction.

Cited by 14 publications

References 0 publications

N-acetylcysteine Plus Deferoxamine Improves Cardiac Function in Wistar Rats After Non-reperfused Acute Myocardial Infarction

N-acetylcysteine Plus Deferoxamine Improves Cardiac Function in Wistar Rats After Non-reperfused Acute Myocardial Infarction

A proteomic study of the effects of ramipril on post‐infarction left ventricular remodelling in the rabbit

Interaction between dyslipidaemia, oxidative stress and inflammatory response in patients with angiographically proven coronary artery disease

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