Is APACHE II a useful tool for clinical research?

Moreno, Rui P.; Nassar, Antônio Paulo

doi:10.5935/0103-507x.20170046

Cited by 24 publications

(25 citation statements)

References 37 publications

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“…Consistent with previous findings, 15–17 we also found that a higher percentage of patients who died underwent mechanical ventilation and used vasoactive drugs compared with those who survived. Non-survivors also had significantly higher APACHE II scores than did survivors, which indicated that these patients had more severe illness than those who survived.…”

Section: Discussionsupporting

confidence: 92%

“…Limited evidence suggests that low serum iron levels, high transferrin levels, and low transferrin saturation are associated with morbidity and mortality of critically ill patients in the ICU. 2 Consistent with previous findings, [15][16][17] we also found that a higher percentage of patients who died underwent mechanical ventilation and used vasoactive drugs compared with those who survived. Nonsurvivors also had significantly higher APACHE II scores than did survivors, which indicated that these patients had more severe illness than those who survived.…”

Section: Discussionsupporting

confidence: 91%

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Serum iron levels are an independent predictor of in-hospital mortality of critically ill patients: a retrospective, single-institution study

et al. 2018

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Objective This study aimed to examine the relationship between serum iron levels and in-hospital mortality in critically ill patients. Methods We retrospectively studied 250 critically ill patients who received treatment at the intensive care unit between June 2015 and May 2017. Blood chemistry and hepatic and renal function were measured. Kaplan-Meier survival curves were plotted according to serum iron levels. Correlations between serum iron levels and other variables were analyzed. Results A total of 165 (66.0%) patients had abnormally low serum iron levels (<10.6 μmol/L). Patients who died during hospitalization had markedly higher Acute Physiology and Chronic Health Evaluation II scores and significantly lower serum iron levels compared with those who survived. Cumulative survival was significantly lower in patients with low serum iron levels than in those with normal serum iron levels in subgroup analysis of older patients (n = 192). Multivariate regression analysis showed that, after adjusting for relevant factors, low serum iron levels remained an independent risk for in-hospital mortality (odds ratio 2.014; 95% confidence interval 1.089, 3.725). Conclusions Low serum iron levels are present in a significant proportion of critically ill patients and are associated with higher in-hospital mortality, particularly in older patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Serum iron levels are an independent predictor of in-hospital mortality of critically ill patients: a retrospective, single-institution study

et al. 2018

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“…For many years, many scoring systems have been used in intensive care units to predict mortality and morbidity. Among these systems, APACHE II is accepted as the most successful scoring system in predicting mortality in all intensive care types and different patient groups (9,10 ). In some articles, it has been reported to be successful in COVID 19 patients (11,12).…”

Section: Discussionmentioning

confidence: 99%

Which Factors Are Predicting the Mortality in Patients With Covid 19 in the Intensive Care Unit?

Parpucu

Turan

Dal³

et al. 2021

Preprint

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Background: COVID 19 infection is a global health problem; clinical and laboratory parameters have been developed to predict this disease-related mortality/morbidity. Some of these parameters are clinical parameters, while some are laboratory parameters. This study aims to determine whether APACHE II, GCS, age, presence of comorbidity, and absolute lymphocyte count effectively predict mortality in patients admitted to intensive care due to COVID 19.Method: We have included 108 PCR-positive COVID 19 patients admitted to the intensive care between 1 October and 31 November 2020 in our research. Demographic characteristics of all patients, APACHE II values within the first 24 hours of admission to intensive care, the Glasgow Coma Scale, the presence of comorbidity, lymphocyte count during intensive care admission, duration of intensive care stay, and the mortality rates were recorded.Results: The average age of 108 individuals evaluated in the study was 67 ± 13.61 years, and 56.5% of the patient group consisted of the geriatric age range. Seventy (64.8%) of the patients were female, eighty-nine (82.4%) patients had at least one comorbidity. In the multivariate analysis, it was determined that lymphocyte value, APACHE II score, and the presence of any comorbidity are independent prognostic factors for mortality when accepted to ICU.Conclusion: In our study, we have determined that age, APACHE II value, presence of comorbidity, and baseline lymphocyte counts are independent predictors of mortality.Trial Registry: SEMA TURAN-2021-01-13T10_31_59Registry address:https://bilimselarastirma.saglik.gov.tr

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“…Os dados foram coletados diariamente, desde admissão do paciente na UTI até o momento de alta para unidade de internação, por meio de um instrumento estruturado de coleta, constituído das variáveis: dados de identificação, demográficos, clínicos (doenças pregressas, medicamentos em uso e exames laboratoriais pré-cirurgia), cirúrgicos (tempo de cirurgia, tempo de circulação extracorpórea, uso de drogas vasoativas, tempo de intubação, exames laboratoriais pós-cirurgia e tipo de cirurgia), período de internação na UTI e índice prognóstico Acute Physiology and Chronic Health Evaluation II (APACHE II) 10 .…”

Section: Métodounclassified

Redução de hemoglobina: risco para lesão renal aguda após revascularização do miocárdio

et al. 2020

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Objetivo: verificar se a redução da taxa de hemoglobina no pós-operatório de revascularização do miocárdio interfere na função renal dos pacientes. Método: estudo observacional e prospectivo, desenvolvido entre fevereiro e junho de 2016, com 51 pacientes que realizaram cirurgia de revascularização do miocárdio em um hospital especializado em cardiologia do Distrito Federal. Os dados foram coletados por meio de um instrumento estruturado. O teste exato de Fisher, Qui-quadrado e Kruskal-Wallis foram empregados para análise estatística. Considerou-se significativo resultados com p≤0,05. Projeto de pesquisa aprovado pelo Comitê de Ética, protocolo 44999215.9.0000.0026. Resultados: Entre os pacientes, 45 (78,9%) evoluíram com lesão renal aguda após revascularização do miocárdio. Idade mais elevada (64±9 anos, p=0,05), tempo de circulação extracorpórea (p=0,05), índice de massa corporal (p=0,02), uso de antibióticos (p=0,03) e redução da taxa de hemoglobina (p=0,04), contribuíram para lesão renal aguda. Conclusão: a redução da taxa de hemoglobina foi associada estatisticamente à lesão renal aguda após revascularização do miocárdio.

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Is APACHE II a useful tool for clinical research?

Cited by 24 publications

References 37 publications

Serum iron levels are an independent predictor of in-hospital mortality of critically ill patients: a retrospective, single-institution study

Serum iron levels are an independent predictor of in-hospital mortality of critically ill patients: a retrospective, single-institution study

Which Factors Are Predicting the Mortality in Patients With Covid 19 in the Intensive Care Unit?

Redução de hemoglobina: risco para lesão renal aguda após revascularização do miocárdio

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