Is benzene exposure from gasoline carcinogenic?

Jamall, Ijaz S.; Willhite, Calvin C.

doi:10.1039/b712987d

Cited by 11 publications

(7 citation statements)

References 91 publications

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“…Gasoline contains mutagenic hydrocardons such as benzene, toluene, ethylbenzene, and xylenes [32, 33]. Role of gasoline in cancer development remains illusive [34]. Some showed positive relationship between chronic gasoline exposure and AML while others failed to establish such correlation [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

Lin

Gao

et al. 2011

American J Hematol

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Risk factors of mydelodysplastic syndromes (MDS) remain largely unknown. We conducted a hospital-based case-control study consisting of 403 newly diagnosed MDS patients according to World Health Organization classification and 806 individually gender and age-matched patient controls from 27 major hospitals in Shanghai, China, to examine relation of lifestyle, environmental, and occupational factors to risk of MDS. The study showed that all MDS (all subtypes combined) risk factors included anti tuberculosis drugs [odds ratio (OR) IntroductionMyelodysplastic syndromes (MDS) represent a heterogeneous group of neoplastic clonal stem cell disorders characterized by clinical presentations of anemia, thrombocytopenia, and leucopenia. MDS may be categorized into subtypes according to histological, immunological, and genetic characteristics. MDS was usually diagnosed by French-American-British (FAB) classification with subtypes including refractory anemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-T), and chronic myelomonocytic leukemia (CMML) [1]. Since its publication in 2001, World Health Organization (WHO) classification for MDS has become widely adopted [2]. In the WHO MDS system, blast cutoff is less than 20% compared to 30% in FAB system. Additional WHO MDS subtypes include refractory cytopenia with multiple dysplasia (RCMD), MDS with isolated del(5q), and MDS unclassifiable (MDS-u) and the WHO MDS system does not include CMML [3].Secondary MDS is usually resulted from radiation and chemotherapy. Little is known about the etiology of primary or de novo MDS. Most previous studies on MDS risk factors focused on FAB MDS [4][5][6]. Here, we report a large hospital-based case-control study of 403 WHO MDS cases and 806 age and sex-matched controls in a Chinese population to assess effects of lifestyle, environmental, and occupational factors on MDS development.

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Section: Discussionmentioning

confidence: 99%

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

Lin

Gao

et al. 2011

American J Hematol

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“…They determined that cohort studies did not demonstrate statistically significant associations between gasoline exposure and leukemia. A more recent review by Jamall and Willhite 35 focused on benzene exposures arising from gasoline. The authors evaluated gasoline exposures using benzene as a surrogate for deriving risk-based clean-up levels for gasoline impacted soil and groundwater.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, 13 studies were excluded because they were either not relevant to occupational gasoline exposures or refinery exposures, which were made irrelevant by follow-up studies, or were reviews that did not contribute new information (Appendix Table A1). 9,35 –37,39,40,42,44 –49 A total of 54 studies were thus identified for evidence-based ranking on quality and relevance to the research question and are included in Appendix Table A2.…”

Section: Methodsmentioning

confidence: 99%

An evidence-based analysis of epidemiologic associations between lymphatic and hematopoietic cancers and occupational exposure to gasoline

Keenan¹,

Gaffney²,

Ronk³

et al. 2013

Hum Exp Toxicol

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The presence of benzene in motor gasoline has been a health concern for potential increased risk of acute myelogenous leukemia and perhaps other lymphatic/hematopoietic cancers for approximately 40 years. Because of the widespread and increasing use of gasoline by consumers and the high exposure potential of occupational cohorts, a thorough understanding of this issue is important. The current study utilizes an evidence-based approach to examine whether or not the available epidemiologic studies demonstrate a strong and consistent association between occupational exposure to gasoline and lymphatic/hematopoietic cancers. Among 67 epidemiologic studies initially identified, 54 were ranked according to specific criteria relating to the relevance and robustness of each study for answering the research question. The 30 highest-ranked studies were sorted into three tiers of evidence and were analyzed for strength, specificity, consistency, temporality, dose-response trends and coherence. Meta statistics were also calculated for each general and specific lymphatic/hematopoietic cancer category with adequate data. The evidence-based analysis did not confirm any strong and consistent association between occupational exposure to gasoline and lymphatic/hematopoietic cancers based on the epidemiologic studies available to date. These epidemiologic findings, combined with the evidence showing relatively low occupational benzene vapor exposures associated with gasoline formulations during the last three decades, suggest that current motor gasoline formulations are not associated with increased lymphatic/hematopoietic cancer risks related to benzene.

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“…Al-Masri and Haddad ( 2012 ) concluded from their study on TENORM emissions from oil- and gas-fired power plants that TENORM was present in fly and bottom ash collected from major Syrian power plants fired by heavy oil and natural gas. On the other hand, many scholars have reported that benzene used in several industry applications found to cause carcinogenic diseases associated with leukemia, and more specifically with acute myeloid leukemia cancer (Vigliani and Saita 1964 ; Aksoy et al 1974 ; Infante et al 1977 ; Yin et al 1978 ; Jamall and Willhiteb 2008 ; WHO 2010 ).…”

Section: Tenorm Occupational Exposure Scenario Modeling and Predictiomentioning

confidence: 99%

Dynamic modeling of TENORM exposure risk during drilling and production

ALNabhani

Khan

Yang

2017

J Petrol Explor Prod Technol

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Exposure to Technologically Enhanced Naturally Occurring Nuclear Radioactive Material (TENORM) from oil and gas drilling and production activities can have effects on both the environment and workers involved in the industry. There is a significant lack of available information regarding dynamic modeling and risk assessment of TENORM occupational exposure in the oil and gas industry, and available studies show that workers in the field are at risk of being exposed to varying levels of radiation. This paper presents a methodology to bridge this knowledge gap by modeling workforce TENORM radiation exposure at different oil and gas operation stages. This was achieved by integrating SHIPP (System Hazard Identification, Prediction and Prevention) Methodology And Rational Theory (SMART approach). The SMART approach was applied to develop an integrated framework for TENORM occupational exposure risk assessment. Application of the proposed approach is illustrated with a scenario, and outcomes from modeling this scenario explain how system degraded as a function of safety barrier performance.

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Is benzene exposure from gasoline carcinogenic?

Cited by 11 publications

References 91 publications

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

Case–control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population

An evidence-based analysis of epidemiologic associations between lymphatic and hematopoietic cancers and occupational exposure to gasoline

Dynamic modeling of TENORM exposure risk during drilling and production

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