Is increased constitutive skin and hair pigmentation an early sign of puberty?

Sitek, Aneta; Żądzińska, Elżbieta; Rosset, Iwona; Antoszewski, Bogusław

doi:10.1016/j.jchb.2013.03.003

Cited by 11 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is believed that sex differences in adult pigmentation originate in puberty due to increased hormonal secretion, while in children it exhibits a different pattern. Many reports indicate that prepubertal girls reveal a darker skin color as well as a darker hair color than boys (Banerjee, ; Frost, ; Frost, ; Kalla & Tiwari, ; Kalla, ; Leguebe, & Twiesselmann, ; Sitek, Rosset, Żądzińska & Antoszewski, ; Tiwari & Kalla, ). The causes and adaptive implications (if any) of this “reversed sexual dimorphism” in pigmentation characteristics have not been explained.…”

Section: Introductionmentioning

confidence: 99%

Do skin and hair pigmentation in prepubertal and early pubertal stages correlate with 2D:4D?

Sitek

Kozieł

Kasielska‐Trojan

et al. 2018

American J Hum Biol

View full text Add to dashboard Cite

Objectives: In most human populations women are less pigmented than men. However, before puberty, boys tend to have lighter skin than girls. Previous research has shown that skin pigmentation in European women is negatively correlated with digit ratio (2D:4D). Therefore, it has been hypothesized that skin pigmentation in females is partially controlled by prenatal hormones. The aim of this study was to examine the correlation between 2D:4D and pigmentation in girls and boys in the prepubertal or early pubertal stages of ontogenesis. Methods: The study group consisted of 598 Polish children (275 boys), aged 6.5-10.5 years. All underwent spectrophotometric measurements of skin and hair melanin index (SMI and HMI) and had the second and the fourth finger on both hands measured directly. Results: SMI (in girls) and HMI (in girls and boys) were positively correlated with age but 2D:4D was not. We regressed SMI and HMI on age and used the residuals as a measure of age-independent pigmentation. In girls, positive correlations were found between resSMI and 2D:4D for the right hand, but there was no correlation with left 2D:4D. In boys, resSMI did not correlate with 2D:4D. The resHMI was not related to 2D:4D in girls or boys. Conclusion: Skin pigmentation in prepubertal or early pubertal girls is related to 2D:4D such that high 2D:4D is associated with higher pigmentation. This relationship may be mediated by the individual rate of sexual maturation.

show abstract

Section: Introductionmentioning

confidence: 99%

Do skin and hair pigmentation in prepubertal and early pubertal stages correlate with 2D:4D?

Sitek

Kozieł

Kasielska‐Trojan

et al. 2018

American J Hum Biol

View full text Add to dashboard Cite

show abstract

“…Non-genetic observational studies have consistently reported darkening of hair and skin pigmentation in children of European ancestry during the peri-pubertal years 17,18 . Furthermore, the established sexual dimorphism in pigmentation 16 reportedly appears from puberty onwards 17 and the relatively darker skin and hair of men compared to women is postulated to reflect the stronger stimulation of melanogenesis by androgens compared to estrogens 21 .…”

Section: Discussionmentioning

confidence: 99%

“…Noting that three novel loci for puberty timing were located proximal to genes previously associated with pigmentation (HERC2, IRF4, C16orf55), we assessed the broader relationship between these traits. It is known that men have darker natural hair colour than women in European ancestry populations 16 and this sex difference appears following the progressive darkening of hair and skin colour during adolescence 17,18 . However, a link between interindividual variation in natural hair colour and puberty timing has not previously been described.…”

Section: Genetic and Phenotypic Links Between Hair Colour And Pubertymentioning

confidence: 99%

Expanded genomic analyses for male voice-breaking highlights a shared phenotypic and genetic basis between puberty timing and hair colour

Hollis

et al. 2018

Preprint

View full text Add to dashboard Cite

The timing of puberty is highly variable and has important consequences for long-term health.Most of our understanding of the genetic control of puberty timing is based on studies in women, as age at menarche is often recorded. Here, we report a multi-trait genome-wide association study for male puberty timing, based on recalled timing of voice breaking and facial hair, with an effective sample size of 205,354 men, nearly four-fold larger than previously reported. We identify 78 independent signals for male puberty timing, including 29 signals not previously associated with puberty in either sex. Novel mechanisms include an unexpected phenotypic and genetic link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and, in Mendelian randomization analyses, shows causal relationships with higher risk of prostate cancer and shorter lifespan. These findings highlight the relationships between puberty timing and later health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes.

show abstract

“…A direct association of just this single variant with blond hair might be caused by the fact that this is an intermediate hair colour category that has a tendency to change in an individual during his/her ontogeny. Many people who are blond during childhood or early adulthood switch to darker hair colour later in life (Rees, 2003; Sitek et al, 2013). It would be a good idea to compare the genetic makeup of people who had blond hair consistently throughout their entire life with those who became darker-haired after adolescence.…”

Section: Discussionmentioning

confidence: 99%

“…Many questions regarding the interactions of the genes involved in the process of melanogenesis and the patterns of phenotype inheritance remain to be answered. One must also remember that hair pigmentation is additionally influenced by environmental factors such as sun exposure (Hessefort et al, 2008), diet (Finner, 2013), hormonal metabolism (Slominski et al, 2004; Tobin, 2008; van Beek et al, 2008), and also by an individual’s age (Sitek et al, 2012; Sitek et al, 2013). It is still necessary to continue research in this field, since populations from different geographical regions and of mixed ancestry might differ in the SNP pool that correlates with a given hair colour.…”

Section: Introductionmentioning

confidence: 99%

Association of five SNPs with human hair colour in the Polish population

Siewierska-Górska

Sitek

Żądzińska

et al. 2016

Preprint

Self Cite

View full text Add to dashboard Cite

Twenty-two variants of the genes involved in hair pigmentation (OCA2, HERC2, MC1R, SLC24A5, SLC45A2, TPCN2, TYR, TYRP1) were genotyped in a group of 186 Polish subjects, representing a range of hair colours (45 red, 64 blond, 77 dark). A genotypephenotype association analysis was performed.Using z-statistics and the associated p-value, we identified three variants highly associated with different hair colour categories (rs12913832:A>G in HERC2, rs1805007:T>C and rs1805008:C>T in MC1R). Two variants: rs1800401:C>T in OCA2 and rs16891982:C>G in SLC45A2 showed a high probability of a relation with hair colour, although that probability did not exceed the threshold of statistical significance after applying the Bonferroni correction. We created and validated mathematical logistic regression models in order to test the usefulness of the sets of polymorphisms for hair colour prediction in the Polish population. We subjected four models to stratified cross-validation. The first model consisted of three polymorphisms that proved to be important in the associative analysis. The second model included, apart from the mentioned polymorphisms, additionally rs16891982:C>G in SLC45A. The third model included, apart from the variants relevant in the associative analysis, rs1800401:C>T in OCA. The fourth model consisted of the set of polymorphisms from the first model supplemented with rs16891982:C>G in SLC45A and rs1800401:C>T in OCA. The validation of our models showed that the inclusion of rs16891982:C>G in SLC45A and rs1800401:C>T in OCA increases the prediction of red hair in comparison with the algorithm only including rs12913832:A>G in HERC2, rs1805007:T>C and rs1805008:C>T in MC1R. The model consisting of all the five above-mentioned genetic variants showed good prediction accuracies, expressed by the area under the curve (AUC) of the receiver operating characteristics: 0.84 for the red-haired, 0.82 for the dark-haired and 0.71 for the blond-haired.

show abstract

Is increased constitutive skin and hair pigmentation an early sign of puberty?

Cited by 11 publications

References 32 publications

Do skin and hair pigmentation in prepubertal and early pubertal stages correlate with 2D:4D?

Do skin and hair pigmentation in prepubertal and early pubertal stages correlate with 2D:4D?

Expanded genomic analyses for male voice-breaking highlights a shared phenotypic and genetic basis between puberty timing and hair colour

Association of five SNPs with human hair colour in the Polish population

Contact Info

Product

Resources

About