Is Ki67 a marker for the transformation of laryngeal dysplasia to carcinoma?

Mirza, Sazan Abdulwahab; Jeannon, Jean Pierre; Soames, J.V.; Wilson, Janet A.

doi:10.1080/00016480500416785

Cited by 13 publications

(15 citation statements)

References 12 publications

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“…In that review, the authors only included 9 articles. Six of these articles were also included in our review [13,[15][16][17][18]23], and three were excluded because they also included invasive carcinomas in their data analysis. The authors made a meta-analysis with p53, the only biomarker with sufficient data to attempt to apply this type of analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Contradictory results have been obtained for this marker (Tables 1, 2): one retrospective study reported a higher rate of malignant progression in cases with elevated Ki67 expression [15], whereas another reported no prognostic significance for this marker [18], and a case-control study showed a higher Ki67 expression in non-progressing controls [23].…”

Section: Proliferation Markersmentioning

confidence: 99%

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Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

Rodrigo

Suárez

Takes

et al. 2011

Eur Arch Otorhinolaryngol

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Some laryngeal epithelial precursor lesions progress to invasive carcinoma and others do not. Routine light microscopic classification has limited value in predicting the evolution of these lesions. This article reviews the experience to date with the use of molecular markers for the prognostic evaluation of laryngeal epithelial precursor lesions. We conducted a thorough review of the published literature to identify those studies using biomarkers to predict malignant progression of laryngeal epithelial precursor lesions. Of the 336 studies identified in this systematic search, 15 met the inclusion criteria and form the basis of this review. Limited studies suggest that certain biomarkers are potentially reliable predictors of malignant progression including various regulators of cell adhesion and invasion (e.g. FAK, cortactin, osteopontin, and CD44v6) and proliferation-associated markers such as TGF-βRII and Kv3.4. The predictive value of these markers, however, has yet to be confirmed in large-scale prospective studies. Although the cell cycle-related proteins are the most frequently studied markers, none have been consistently reliable across multiple studies. The absence of standardization in methodologies, test interpretation, and other parameters may contribute to study inconsistencies. Various biomarkers have proved to have potential prognostic value and could be clinically relevant. The utility and prognostic power of these biomarkers should be confirmed in large, well-designed, standardized prospective studies.

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Section: Discussionmentioning

confidence: 99%

Section: Proliferation Markersmentioning

confidence: 99%

Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

Rodrigo

Suárez

Takes

et al. 2011

Eur Arch Otorhinolaryngol

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“…Mirza et al 21 studied 80 patients histologically diagnosed with laryngeal mucosal dysplasia and performed immunohistochemistry tests for Ki-67. Ki-67 expression was categorized in terms of intensity in a scale from 0 to 4.…”

Section: Discussionmentioning

confidence: 99%

Valor prognóstico da correlação imunoistoquímica do Ki-67 e p53 em carcinomas epidermóides da laringe

Rodrigues

Motta

Machado

et al. 2008

Rev. Bras. Otorrinolaringol.

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Prognost ic histological factors may contribute to determine the evolution of this neoplasia. Aim: To correlate p53 and Ki-67 immunohistochemical expression with age, histological degree, lymph node involvement and pathological staging in patients with laryngeal epidermoid carcinomas. Methods:We assessed thirty consecutive cases of laryngeal epidermoid carcinomas submitted to immunohistochemistry to check the expression of p53 e Ki-67 antibodies. Results: Mean age was of 56.2 years and the immunoexpression of the markers was observed in the group with more than 50 years of age, especially that o the ki-67 antibody (p=0.032). There was no relation between p53 and Ki-67 with lymph node involvement. Ki-67 was expressed in 70% of the high histology level cases and in 80% in the low histology ones; while p53 was of 70% only in the high level cases. Pathology staging showed that in the group of advanced carcinomas, p53 expression was of 61.5%, while Ki-67 proved positive for the early cases (100%) and advanced (73.1%). Conclusion: There were no significant differences between p53 and Ki-67 immunoexpression in laryngeal epidermoid carcinoma, except in the group of patients with more than 50 years of age, when Ki-67 expression was significantly higher.

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“…The management of these identified patients may include chemo-preventive approaches, local surgical therapies such as cord stripping, or laser treatment, in addition to intensive smoking cessation programmes in an effort to prevent the subsequent development of cancer [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Ki67, p27 and p53 Expression in Squamous Epithelial Lesions of Larynx

Mondal¹,

Kaushik

Datta

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Precise assessment of the biological behavior and progression of squamous epithelial lesions of the larynx with a view to predict the prognosis and therapeutic challenges remains an elusive goal. The knowledge and data regarding the expression of proliferative markers indicating the biological activity in different histological grades of squamous epithelial lesions are lacking till date. To evaluate the relationship between Ki67, p27 and p53 expression as well as topographic distribution of Ki67 with the histological subtypes or grades of laryngeal squamous intraepithelial and invasive lesions. Sixty-two consecutive cases with histologically documented intraepithelial and invasive squamous lesion were studied for Ki67, p27 and p53 expression. MannWhitney U, Kruskal-Wallis and Spearman's correlation tests were used for statistical analysis. The mean Ki67 labeling index in hyperplasia, dysplasia and carcinoma were 12.15, 22.03 and 35.53 % respectively and this difference was statistically significant (P \ 0.05). There was strong positive correlation between Ki67 labeling index and increasing grades of squamous lesions. p27 expression was progressively decreased and p53 expression was progressively increased as the lesions progressed from hyperplasia to dysplasia and dysplasia to carcinoma. The topographic distribution of Ki67 positive cells increased with progressive grades of dysplasia. The Ki67 labeling index correlates well with the histological grade of both intraepithelial and invasive lesions of the larynx. And the topographic distribution of Ki67 expression depends on the grade of the dysplasia. Hence, Ki67 expression has a definite role in predicting the biological behavior of the lesions.

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Is Ki67 a marker for the transformation of laryngeal dysplasia to carcinoma?

Cited by 13 publications

References 12 publications

Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

Valor prognóstico da correlação imunoistoquímica do Ki-67 e p53 em carcinomas epidermóides da laringe

Ki67, p27 and p53 Expression in Squamous Epithelial Lesions of Larynx

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