Valor prognóstico da correlação imunoistoquímica do Ki-67 e p53 em carcinomas epidermóides da laringe

Abstract

Prognost ic histological factors may contribute to determine the evolution of this neoplasia. Aim: To correlate p53 and Ki-67 immunohistochemical expression with age, histological degree, lymph node involvement and pathological staging in patients with laryngeal epidermoid carcinomas. Methods:We assessed thirty consecutive cases of laryngeal epidermoid carcinomas submitted to immunohistochemistry to check the expression of p53 e Ki-67 antibodies. Results: Mean age was of 56.2 years and the immunoexpression of the markers was observed in the group with more than 50 years of age, especially that o the ki-67 antibody (p=0.032). There was no relation between p53 and Ki-67 with lymph node involvement. Ki-67 was expressed in 70% of the high histology level cases and in 80% in the low histology ones; while p53 was of 70% only in the high level cases. Pathology staging showed that in the group of advanced carcinomas, p53 expression was of 61.5%, while Ki-67 proved positive for the early cases (100%) and advanced (73.1%). Conclusion: There were no significant differences between p53 and Ki-67 immunoexpression in laryngeal epidermoid carcinoma, except in the group of patients with more than 50 years of age, when Ki-67 expression was significantly higher.

Expression of Ki-67 and P16 INK4a in chemically-induced perioral squamous cell carcinomas in mice.

“…In this study, there was a strong direct correlation between the mean tumor volume and tumor malignancy grade, ie, the lesions classified as high grade showed the highest rates of tumor growth when compared with the low-grade ones, showing that morphologically undifferentiated cells are genetically unstable and easily escape from cell cycle control mechanisms, with a tendency to have high cell proliferation rates, in agreement with other studies 16,17 . The Ki-67 immunoreactivity relates to evidence of cell proliferation, so that it is expressed in all cell cycle phases but G0, in which cells are quiescent 18 .…”

“…However, it is interesting to note that in several studies the Ki-67 presents a tendency to strong direct correlation with the lesion malignancy degree, being valuable as a prognostic predictor 17,18 . The p16 INK4a tumor suppressor gene, encoding the p16 protein, is inactivated by hypermethylation in several types of malignancies, including oral squamous cell carcinoma, constituting a crucial event in the early stages of malignant transformation of the affected tissue.…”

Avaliação de voz e qualidade de vida após laringectomia supracricóide

“…The sample of subjects enrolled in this study was constituted by male patients from 46 to 71 years of age, mean age of 59.3 years, in agreement with the literature that indicates a higher predominance of male patients (1,3) .…”

“…Larynx cancer is considered the most common head and neck malignant neoplasm, mainly occurring in male individuals, with an incidence of 130.000 new cases a year in the world (1) . It's main symptom is dysphonia, once the glottis region is generally more affected, followed by the supraglottis and subglottis regions (2) .…”

“…It's main symptom is dysphonia, once the glottis region is generally more affected, followed by the supraglottis and subglottis regions (2) . The most common histological type in larynx is the spinocellular carcinoma, with a ratio of seven men to one woman (1) and a higher incidence from 50 years of age (3) .…”