Is the din really harmless? Long-term effects of non-traumatic noise on the adult auditory system

Gourévitch, Boris; Edeline, Jean‐Marc; Occelli, Florian; Eggermont, Jos J.

doi:10.1038/nrn3744

Cited by 67 publications

(51 citation statements)

References 109 publications

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“…That is, SNHL, which may traditionally be categorized as an inner ear disorder whose primary manifestation is related to elevated auditory thresholds, may be also characterized by neurodegenerative, synaptic, and neural firing pattern deficits (Kujawa & Liberman, 2006; 2009; Gourévitch et al, 2014; Nash & Sharma, 2014). Likewise, individuals with diagnosed ANSD, which may typically be considered a neurologic deficiency, often suffer from elevated auditory thresholds as well.…”

Section: 2 Similarities In Pathophysiology Between Snhl and Ansdmentioning

confidence: 99%

“…For instance, precise neural activity is needed for the highly accurate temporal processing that must take place in the auditory system in order to decode complex acoustic signals (i.e., speech and speech in noise; Frisina & Frisina, 1997). Thus, a downregulation of inhibition, secondary to deprivation-induced homeostatic plasticity, could lead to compromised temporal processing abilities (Gourévitch et al, 2014). In addition, recent reports have linked hyperexcitability and lack of neuronal inhibition to tinnitus, hyperacusis, and aging (e.g., Schaette & Kempter, 2006; Caspary et al, 2008; Gold & Bajo, 2014; Gourévitch et al, 2014).…”

Section: 3 How Might VIII Nerve Dys-synchrony Alter the Central Audmentioning

confidence: 99%

“…Thus, a downregulation of inhibition, secondary to deprivation-induced homeostatic plasticity, could lead to compromised temporal processing abilities (Gourévitch et al, 2014). In addition, recent reports have linked hyperexcitability and lack of neuronal inhibition to tinnitus, hyperacusis, and aging (e.g., Schaette & Kempter, 2006; Caspary et al, 2008; Gold & Bajo, 2014; Gourévitch et al, 2014). It is plausible that similar changes in central nervous system structure and function could also occur in a system in which deprivation via reduced or abnormally patterned activity was occurring, especially in development.…”

Section: 3 How Might VIII Nerve Dys-synchrony Alter the Central Audmentioning

confidence: 99%

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Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder

Sharma

Cardon

2015

Hearing Research

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Cortical development is dependent to a large extent on stimulus-driven input. Auditory Neuropathy Spectrum Disorder (ANSD) is a recently described form of hearing impairment where neural dys-synchrony is the predominant characteristic. Children with ANSD provide a unique platform to examine the effects of asynchronous and degraded afferent stimulation on cortical auditory neuroplasticity and behavioral processing of sound. In this review, we describe patterns of auditory cortical maturation in children with ANSD. The disruption of cortical maturation that leads to these various patterns includes high levels of intra-individual cortical variability and deficits in cortical phase synchronization of oscillatory neural responses. These neurodevelopmental changes, which are constrained by sensitive periods for central auditory maturation, are correlated with behavioral outcomes for children with ANSD. Overall, we hypothesize that patterns of cortical development in children with ANSD appear to be markers of the severity of the underlying neural dys-synchrony, providing prognostic indicators of success of clinical intervention with amplification and/or electrical stimulation.

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Section: 2 Similarities In Pathophysiology Between Snhl and Ansdmentioning

confidence: 99%

Section: 3 How Might VIII Nerve Dys-synchrony Alter the Central Audmentioning

confidence: 99%

Section: 3 How Might VIII Nerve Dys-synchrony Alter the Central Audmentioning

confidence: 99%

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Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder

Sharma

Cardon

2015

Hearing Research

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“…There is evidence from animal models that long-term noise exposure at levels well below those causing cochlear trauma can cause changes to the cortical tonotopic map and that these changes may adversely affect sound discrimination (for a review, see Gourevitch, Edeline, Occelli, & Eggermont, 2014). So some of the effects of noise exposure may be the result of central plasticity, rather than purely cochlear effects.…”

Section: Relation Between Noise Exposure and Perceptual Deficits In Hmentioning

confidence: 99%

Perceptual Consequences of “Hidden” Hearing Loss

2014

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Dramatic results from recent animal experiments show that noise exposure can cause a selective loss of high-threshold auditory nerve fibers without affecting absolute sensitivity permanently. This cochlear neuropathy has been described as hidden hearing loss, as it is not thought to be detectable using standard measures of audiometric threshold. It is possible that hidden hearing loss is a common condition in humans and may underlie some of the perceptual deficits experienced by people with clinically normal hearing. There is some evidence that a history of noise exposure is associated with difficulties in speech discrimination and temporal processing, even in the absence of any audiometric loss. There is also evidence that the tinnitus experienced by listeners with clinically normal hearing is associated with cochlear neuropathy, as measured using Wave I of the auditory brainstem response. To date, however, there has been no direct link made between noise exposure, cochlear neuropathy, and perceptual difficulties. Animal experiments also reveal that the aging process itself, in the absence of significant noise exposure, is associated with loss of auditory nerve fibers. Evidence from human temporal bone studies and auditory brainstem response measures suggests that this form of hidden loss is common in humans and may have perceptual consequences, in particular, regarding the coding of the temporal aspects of sounds. Hidden hearing loss is potentially a major health issue, and investigations are ongoing to identify the causes and consequences of this troubling condition.

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“…There is evidence from both animal studies (Kujawa & Liberman, 2009) and human studies (Epstein et al, 2016;Stamper & Johnson, 2015) that noise exposure can lead to loss of synapses between the inner hair cells in the cochlea and the neurons in the auditory nerve, even when the audiogram remains normal or near-normal (Gourevitch et al, 2014;Wan & Corfas, 2015). Following the loss of synapses, the neurons in the auditory nerve degenerate, but this can take a considerable time, up to several years (Kujawa & Liberman, 2015).…”

Section: Effects Of Noise Exposure Not Revealed By the Audiogrammentioning

confidence: 99%

A review of the perceptual effects of hearing loss for frequencies above 3 kHz

Moore

2016

International Journal of Audiology

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Background: Hearing loss caused by exposure to intense sounds usually has its greatest effects on audiometric thresholds at 4 and 6 kHz. However, in several countries compensation for occupational noise-induced hearing loss is calculated using the average of audiometric thresholds for selected frequencies up to 3 kHz, based on the implicit assumption that hearing loss for frequencies above 3 kHz has no material adverse consequences. This paper assesses whether this assumption is correct. Design: Studies are reviewed that evaluate the role of hearing for frequencies above 3 kHz. Results: Several studies show that frequencies above 3 kHz are important for the perception of speech, especially when background sounds are present. Hearing at high frequencies is also important for sound localization, especially for resolving front-back confusions. Conclusions: Hearing for frequencies above 3 kHz is important for the ability to understand speech in background sounds and for the ability to localize sounds. The audiometric threshold at 4 kHz and perhaps 6 kHz should be taken into account when assessing hearing in a medico-legal context.

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Is the din really harmless? Long-term effects of non-traumatic noise on the adult auditory system

Cited by 67 publications

References 109 publications

Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder

Cortical development and neuroplasticity in Auditory Neuropathy Spectrum Disorder

Perceptual Consequences of “Hidden” Hearing Loss

A review of the perceptual effects of hearing loss for frequencies above 3 kHz

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