Is the effect of smoking on rosacea still somewhat of a mystery?

Kucukunal, Asli; Altunay, İlknur Kıvanç; Arıcı, Janset Erkul; Çerman, Aslı Aksu

doi:10.3109/15569527.2015.1046184

Cited by 7 publications

(19 citation statements)

References 23 publications

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“…In this study, we also found that tobacco consumption increased the risk of PPR and PhR, but not of ETR. Although a previous study showed a higher smoking rate among ETR patients, 11 We acknowledge that this study has some limitations. Firstly, although our meta-analysis was conducted using high-quality casecontrol studies, the potential data recall bias in each of the included studies may have an impact on the general results of our study.…”

Section: Discussionmentioning

confidence: 81%

“…Then, 29 articles were excluded for the following reasons: being unrelated to the topic (n = 11), full text not found (n = 2), being a conference summary (n = 7), not meeting the inclusion criteria (n = 6), and potentially coming from the same database (n = 3). Finally, we included 12 case‐control studies for the meta analysis 5,11,12,15,18‐25 . A flow diagram of the literature search is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, we included 12 case-control studies for the meta analysis. 5,11,12,15,[18][19][20][21][22][23][24][25] A flow diagram of the literature search is presented in Figure 1. Table 1.…”

Section: Literature Searchmentioning

confidence: 99%

“…In the general analysis for all included articles, tobacco consumption did not appear to increase the risk of rosacea (OR = 1.22, 95% CI 0.98-1.52, P = .082; I 2 = 90.0%, P = .000) (Figure 2A). However, in a subtype analysis (involving five articles), 5,11,12,15,23 we found a decreased risk of rosacea in current smokers (OR = 0.54, 95% CI 0.41-0.72, P = .000; I 2 = 39.9%, P = .155) ( Figure 2B) and increased risk in ex-smokers (OR = 1.84, 95% CI 1.38-2.47, P = .000; I 2 = 39.9%, P = .155)( Figure 2C) (Supplement Table 1). Considering the high weightage of Spoendlin's study, we performed subtype analysis again after removing that article.…”

Section: The Risk Of Rosacea In Smokingmentioning

confidence: 99%

“…We further analyzed the relationship between rosacea subtypes and smoking based on 3 published articles. 5,11,21 Tobacco consumption appeared to increase the risk of papulopustular rosacea (PPR) (OR = 2.33, 95% CI 1.06-5.14, P = .036; I 2 = 75.3%, P = .017) ( Figure 3B) and phymatous rosacea (PhR) (OR = 4.37, 95% CI 1.21-15.79, P = .024; I 2 = 51.6%, P = .127) ( Figure 3C) but was not associated with erythemato-telangiectatic rosacea (ETR) (OR = 2.30, 95% CI 0.66-8.13, P = .193; I 2 = 90.0%, P = .000) ( Figure 3A) (Table S1).…”

Section: The Risk Of Rosacea In Smokingmentioning

confidence: 99%

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Association between rosacea and smoking: A systematic review and meta‐analysis

Yuan

Yin

2021

Dermatologic Therapy

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Rosacea is a chronic inflammatory disease of the centrofacial region. However, the association between rosacea and smoking remains controversial. To evaluate the association between rosacea and smoking, we performed a systematic review and meta-analysis. A comprehensive systematic search of literature published before October 15, 2020 on online databases (including Web of Science, PubMed, Cochrane Library, and Embase) was performed. The pooled odds ratios (ORs) were calculated. 12 articles were included, covering 80 156 controls and 54 132 patients with rosacea. Tobacco consumption was not found to increase the risk of rosacea. However, using subtype analysis (involving 5 articles), we found there was a decreased risk of rosacea in current smokers but an increased risk in ex-smokers. In addition, smoking appears to increase the risk of papulopustular rosacea and phymatous rosacea. Analysis of all included studies also showed that ex-smoking was associated with an increased risk, while current smoking was associated with a reduced risk of rosacea. In order to prevent many diseases, including rosacea, the public should be encouraged to avoid smoking.

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Section: Discussionmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

“…Finally, we included 12 case-control studies for the meta analysis. 5,11,12,15,[18][19][20][21][22][23][24][25] A flow diagram of the literature search is presented in Figure 1. Table 1.…”

Section: Literature Searchmentioning

confidence: 99%

Section: The Risk Of Rosacea In Smokingmentioning

confidence: 99%

Section: The Risk Of Rosacea In Smokingmentioning

confidence: 99%

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Association between rosacea and smoking: A systematic review and meta‐analysis

Yuan

Yin

2021

Dermatologic Therapy

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Revisiting Rosacea Criteria

Saleem

2018

Dermatologic Clinics

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Cigarette Smoking and Risk of Incident Rosacea in Women

Li¹,

Cho²,

Drucker³

et al. 2017

American Journal of Epidemiology

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The relationship between smoking and rosacea is poorly understood. We aimed to conduct the first cohort study to determine the association between smoking and risk of incident rosacea. We included 95,809 women from Nurses' Health Study II (1991-2005). Information on smoking was collected biennially during follow-up. Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005. We used Cox proportional hazards models to estimate age- and multivariable-adjusted hazard ratios and 95% confidence intervals for the association between different measures of smoking and risk of rosacea. During follow-up, we identified 5,462 incident cases of rosacea. Compared with never smoking, we observed an increased risk of rosacea associated with past smoking (multivariable-adjusted hazard ratio = 1.09, 95% confidence interval: 1.03, 1.16) but a decreased risk associated with current smoking (hazard ratio = 0.65, 95% confidence interval: 0.58, 0.72). We further found that increasing pack-years of smoking was associated with an elevated risk of rosacea among past smokers (P for trend = 0.003) and with a decreased risk of rosacea among current smokers (P for trend < 0.0001). The risk of rosacea was significantly increased within 3-9 years since smoking cessation, and the significant association persisted among past smokers who had quit over 30 years before.

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Is the effect of smoking on rosacea still somewhat of a mystery?

Abstract: While a significantly increased risk of developing rosacea among smokers was observed in this study, ETR seems to be the disease of active smokers. Further studies are required for better understanding of the association between rosacea and smoking.

Cited by 7 publications

References 23 publications

Association between rosacea and smoking: A systematic review and meta‐analysis

Association between rosacea and smoking: A systematic review and meta‐analysis

Revisiting Rosacea Criteria

Cigarette Smoking and Risk of Incident Rosacea in Women

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