Is the lung parenchyma strip a true airway preparation?

Eyre, P.; Mirbahar, K. B.

doi:10.1007/bf01967610

Cited by 11 publications

(3 citation statements)

References 25 publications

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“…The LPS from the guinea pig [156,157], rat [158], rabbit [159], cat and dog [160], horse [161], pig [162], sheep [163], cow [164], monkey [165], and man [166], have been shown to react to a wide range of autonomic and autacoid agents. However, the use of this preparation as a true airway model has been questioned and several investigators have suggested it no longer be used for the investigation specifically of peripheral airway reactivity [156,167,168]. Nevertheless, the LPS provides a useful model for the pharmacological study of the general pulmonary anaphylactic reaction and for screening antianaphylactic compounds.…”

Section: (Ii) Lung Parenchyma Stripmentioning

confidence: 99%

Pharmacological studies of pulmonary anaphylaxisin vitro: A review

Ogunbiyi

Eyre

1985

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Section: (Ii) Lung Parenchyma Stripmentioning

confidence: 99%

Pharmacological studies of pulmonary anaphylaxisin vitro: A review

Ogunbiyi

Eyre

1985

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“…There is evidence to suggest that the effect of AA on the parenchymal strip preparation may not accurately reflect its action of peripheral airways (Eyre & Mirbahar, 1981). This preparation also comprises vascular smooth muscle which is thought to contribute substantially to its contractile and metabolic profile, and possibly some non-muscular contractile elements (Goldie et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

“…The behaviour of parenchymal strips is believed to reflect accurately that of the peripheral airways (Lulich et al, 1976), although Eyre & Mirbahar (1981) suggest that the reactivity of this tissue is a function of airway, vascular and non-muscular contractile elements. Therefore data indicating that AA produces consistent constriction of parenchymal strips (Mitchell & Denborough, 1980) may not be of any significant relevance to airway smooth muscle.…”

Section: Introductionmentioning

confidence: 99%

The effects of arachidonic acid and non‐steroidal anti‐inflammatory drugs on intrapulmonary airways of the guinea‐pig

Clay¹,

Fenske²

1984

British J Pharmacology

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1A method is described in which changes in intrapulmonary airway tone of guinea-pig isolated lungs are reflected by changes in intraluminal perfusion pressure. 2 A supramaximal dose of arachidonic acid (AA) (61iM) was found to have little on no action on baseline perfusion pressure. However, following elevation of perfusion pressure with histamine, AA caused a dose-dependent pressure decrease. This was also mimicked by prostaglandin El (PGE1) and PGE2-3 AA induced a reduction of histamine elevated perfusion pressure which was inhibited, dosedependently, by several non-steroidal anti-inflammatory agents including indomethacin, phenylbutazone, aspirin, benoxaprofen, BW755C and phenidone. Their respective rank order of potency appeared to correlate with their activity against microsomal cyclo-oxygenase. 4 Indomethacin, phenylbutazone and aspirin induced augmentation of the elevated perfusion pressure due to histamine, whereas BW755C did not. 5 We suggest that the primary arachidonate metabolite present in intrapulmonary airways following histamine-induced constriction is probably a relaxant of the E series. However, our data suggest that both cyclo-oxygenase and lipoxygenase products are associated with the maintenance of airway tone.

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Use of isolated perfused lung in determining pulmonary disposition and potential toxicological significance of inhaled environmental pollutants

Mehendale

1982

Enviro Toxic and Chemistry

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Recent interest in the investigation of the effect of environmental pollutants on the nonrespiratory and respiratory functions of the lung has stimulated the refinement and application of the technique of perfusing isolated intact lung preparations from suitable experimental animals in toxicological and biochemical studies. Available techniques include perfusion with whole blood or constituted perfusion media via pulmonary artery while maintaining ventilation with alternating negative or positive pressure. Viable, ventilating lung preparations can be maintained for 3 h. Such preparations have been employed for studies of uptake, metabolism and disposition of intratracheally or vascularly administered endogenous or exogenous chemicals. Recent development in unilateral or split‐lung perfusion preparations will undoubtedly further enhance the application of these techniques in the study of the interactions of endogenous and exogenous substances in the lung tissue. Isolated, perfused split‐lung preparations are particularly suited to investigate early toxic effects of inhaled pollutants in an attempt to gain insight into underlying mechanisms that lead to lung injury. Areas in which intact perfused lungs have been employed extensively with notable success include uptake, metabolism and disposition of toxic chemicals. These preparations have been used to study the effects of gases such as SO2, NO2, O3 and CO on lung metabolism. Perfused lung preparations have been particularly useful in demonstrating pulmonary activation of toxic chemicals and in the demonstration of specific effects on the lung after chronic administration of chemicals. Areas which have not been actively investigated include the uptake and disposition of gases or vapors, effects of toxic chemicals on respiratory and nonrespiratory functions of the lung and alteration in the hemodynamics of the pulmonary circulation in the presence of interacting chemical or physical agents. It should be technically feasible to adapt the perfused lung preparations for such investigations, and interest in this area will continue.

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Is the lung parenchyma strip a true airway preparation?

Cited by 11 publications

References 25 publications

Pharmacological studies of pulmonary anaphylaxisin vitro: A review

Pharmacological studies of pulmonary anaphylaxisin vitro: A review

The effects of arachidonic acid and non‐steroidal anti‐inflammatory drugs on intrapulmonary airways of the guinea‐pig

Use of isolated perfused lung in determining pulmonary disposition and potential toxicological significance of inhaled environmental pollutants

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