Is the Val16Ala Manganese Superoxide Dismutase Polymorphism Associated With the Aging Process?

Taufer, Maristela; Peres, Alessandra; Andrade, Vanessa Moraes de; Oliveira, Graziela de; Sá, Gustavo; Canto, Margo Etiene Pazzato do; Santos, Adriana R. dos; Bauer, Moisés Evandro; Cruz, Ivana Beatrice Mânica da

doi:10.1093/gerona/60.4.432

Cited by 64 publications

(36 citation statements)

References 32 publications

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“…Subjects were recruited from the Cardiology Service, São Lucas Hospital (SLH), Brazil and from an epidemiological study of aging and non-transmissible diseases conducted in the metropolitan area of Gravatai, Porto Alegre. Previous genetic studies have been performed in this research project (24,25). Minimal and maximal ages were 35 and 92 years old, respectively.…”

Section: Methodsmentioning

confidence: 99%

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Piccoli

Gottlieb

Castro

et al. 2008

Arq Bras Endocrinol Metab

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Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a signifi cant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist. A síndrome metabólica (SM) é um agrupamento de fatores de riscos cardiovasculares, tais como hipertensão, dislipidemia, obesidade e diabetes tipo 2. Realizou-se um estudo caso-controle para analisar a associação entre o polimorfi smo (894G>T do gene da enzima endotelial oxido nítrico sintetase (NOS3) e a SM em 616 voluntários. As freqüências genotípicas foram: TT = 9,3%, GG = 37,2% e TG = 53,6%, e as freqüências alélicas T = 0,36 e G = 0,64. Observou-se freqüência mais alta do genótipo TT em homens com SM do que nos controles, independentemente de outros fatores (p = 0,02). Também observou-se associação entre hipertensão e o genótipo TT nas mulheres. Os dados do estudo sugerem que o polimorfi smo 894G>T pode ter papel significativo na interação entre riscos metabólicos, tais como a hipertensão e a SM, ainda que existam diferenças relacionadas ao sexo.

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Section: Methodsmentioning

confidence: 99%

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Piccoli

Gottlieb

Castro

et al. 2008

Arq Bras Endocrinol Metab

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“…Briefly, of the 22 studies (Wang et al, 2001;Woodson et al, 2001;Lin et al, 2003;Liu et al, 2004;Wang et al, 2004;Li et al, 2005;Taufer et al, 2005;Ho et al, 2006;Choi et al, 2007;di Martino et al, 2007;Ergen et al, 2007;Kang et al, 2007;Arsova-Sarafinovska et al, 2008;Iguchi et al, 2008;Mikhak et al, 2008;Bica et al, 2009;Cheng et al, 2009;Iguchi et al, 2009;Sun et al, 2009;Zejnilovic etal., 2009), the sample size ranged between 100 and 3,030, and there were twelve studies on prostate cancer, four studies on esophageal cancer, and six studies on lung cancer. All studies, except for five of them (Taufer et al, 2005;Bica et al, 2009;Sun et al, 2009;Zejnilovic et al, 2009), indicated that the distribution of genotypes in the controls was consistent with HardyWeinberg equilibrium, while only one study conducted by Lin et al (2003) contained no data for Hardy-Weinberg equilibrium.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In prostate cancer, we excluded three studies (Taufer et al, 2005;Ergen et al, 2007;Bica et al; because their controls were not in Hardy-Weinberg equilibrium and we found that the data did not statistically alter the conclusions of our analysis in the homozygote model (Ala/ Ala versus Val/Val, OR = 1.13; 95% CI = 1.01-1.27) or dominant model (Val/Ala+Ala/Ala versus Val/Val, OR = 1.11; 95% CI = 1.01-1.22). In the subgroup analysis by disease stages, one study (Wang et al, 2001) was excluded because the control was not in Hardy-Weinberg equilibrium.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Sun

Wang²,

Lu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Altered expression or function of manganese superoxide dismutase (MnSOD) has been shown to be associated with cancer risk but assessment of gene polymorphisms has resulted in inconclusive data. Here a search of published data was made and 22 studies were recruited, covering 20,025 case and control subjects, for metaanalyses of the association of MnSOD polymorphisms with the risk of prostate, esophageal, and lung cancers. The data on 12 studies of prostate cancer (including 4,182 cases and 6,885 controls) showed a statistically significant association with the risk of development in co-dominant models and dominant models, but not in the recessive model. Subgroup analysis showed there was no statistically significant association of MnSOD polymorphisms with aggressive or nonaggressive prostate cancer in different genetic models. In addition, the data on four studies of esophageal cancer containing 620 cases and 909 controls showed a statistically significant association between MnSOD polymorphisms and risk in all comparison models. In contrast, the data on six studies of lung cancer with 3,375 cases and 4,050 controls showed that MnSOD polymorphisms were significantly associated with the decreased risk of lung cancer in the homozygote and dominant models, but not the heterozygote model. A subgroup analysis of the combination of MnSOD polymorphisms with tobacco smokers did not show any significant association with lung cancer risk, histological type, or clinical stage of lung cancer. The data from the current study indicated that the Ala allele MnSOD polymorphism is associated with increased risk of prostate and esophageal cancers, but with decreased risk of lung cancer. The underlying molecular mechanisms warrant further investigation.

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“…Previous studies have investigated a mutation at c.47T > C (rs4880 polymorphism) in the SOD2 gene and its potential correlation with POAG; results though remain controversial [18][19][20]. Because of: the important role of mitochondria in retinal ganglion cells apoptosis, the increasing evidence of oxidative stress involvement in many pathologic conditions [21,22] including glaucoma, the presence of Mn-SOD enzyme in mitochondria and controversial results from previous studies, we decided to investigate whether this mutation is a risk factor for POAG in Greek population. …”

Section: Introductionmentioning

confidence: 99%

Association of Superoxide Dismutase 2 Polymorphism Rs4880 and Open-Angle Glaucoma in a Greek Patients’ Cohort

Lavaris¹,

Gazouli²,

Kitsos³

et al. 2016

J Genet Syndr Gene Ther

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Purpose: Glaucoma is a multifactorial optic neuropathy and leading cause of visual impairment and blindness. Multigenic inheritance hypothesis is being investigated over the past decades and numerous mainly causative and synergic polymorphisms have been revealed. Aim of this study is to investigate whether superoxide dismutase 2 (SOD2) polymorphism rs4880 is associated with primary open angle glaucoma (POAG) in Greek population. Materials and method:This is a case control study of 106 POAG patients and 120 thoroughly examined, unrelated, healthy control subjects of Greek origin, surveyed for SOD2 polymorphism rs4880 and potential correlation to POAG.Results: SOD2 rs4880 polymorphism showed no statistically significant difference between POAG patients and healthy controls. Mean intraocular pressure (IOP) of both eyes of the heterozygous (T/C) group was found significantly higher than in homozygous (T/T) group (19.13 ± 0.60 vs. Conclusion:Our study did not find any significant association between SOD2 rs4880 polymorphism and POAG. Mean IOP of the polymorphic (C) allele carriers was found significantly higher than in homozygous (T/T) group. As we cannot reject the possibility that oxidative stress might be a crucial factor for the POAG development further studies may be needed to confirm the importance of SOD2 gene in POAG pathogenesis.

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Is the Val16Ala Manganese Superoxide Dismutase Polymorphism Associated With the Aging Process?

Cited by 64 publications

References 32 publications

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Different Association of Manganese Superoxide Dismutase Gene Polymorphisms with Risk of Prostate, Esophageal, and Lung Cancers: Evidence from a Meta-analysis of 20,025 Subjects

Association of Superoxide Dismutase 2 Polymorphism Rs4880 and Open-Angle Glaucoma in a Greek Patients’ Cohort

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