Is There a Possible Relation Between Atrophic Gastritis and Premature Atherosclerosis?

Kutluana, Ufuk; Şımşek, İlkay; Akarsu, Mesut; Küpelioğlu, Ali; Karasu, Şebnem; Altekin, Emel

doi:10.1111/j.1523-5378.2005.00356.x

Cited by 12 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, arterial stiffness advanced in accordance with the severity of AG. This correlation between AG and arterial stiffness has been reported in a previous study, in which carotid intima-media thickness was greater in subjects with atrophic gastritis 24) ; however, no report has shown the relation of AG and arterial stiffness evaluated by baPWV or CAVI.…”

Section: Discussionmentioning

confidence: 66%

See 1 more Smart Citation

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

Torisu

Takata

Ansai

et al. 2009

JAT

View full text Add to dashboard Cite

Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects.

show abstract

Section: Discussionmentioning

confidence: 66%

“…For more accurate diagnosis, HP status and AG should be determined by endoscopy and biopsy. Fourth, we did not measure lipoprotein-a 28) , vitamin B12 24) , fibrinogen, and cytokine levels 27) , all of which have been reported to be related to arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

Torisu

Takata

Ansai

et al. 2009

JAT

View full text Add to dashboard Cite

show abstract

“…Some studies demonstrated an association between H. pylori infection and hyperhomocysteinemia 1-4, while the other studies did not. 15, 16, 21-23.…”

Section: Discussionmentioning

confidence: 98%

No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese

Itou¹,

Goto²,

Kondo³

et al. 2007

Int. J. Med. Sci.

View full text Add to dashboard Cite

Recent studies have suggested that Helicobacter pylori (H. pylori) infection might be a risk factor for atherosclerosis. Since the bacterium has not been isolated from atherosclerotic lesions, a direct role in atherogenesis is not plausible. We examined associations of plasma total homocysteine (tHcy) and serum folate, independent risk factors for atherosclerosis, with H. pylori infection and subsequent gastric atrophy among 174 patients (78 males and 96 females) aged 20 to 73 years, who visited an H. pylori eradication clinic of Nagoya University from July 2004 to October 2005. Polymorphism genotyping was conducted for methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) 28-bp tandem repeats by PCR with confronting two-pair primers and PCR, respectively. H. pylori infection and gastric atrophy were not significantly associated with hyperhomocysteinemia (tHcy ≥ 12 nmol/ml), when adjusted by sex, age, smoking, alcohol, and genotypes of MTHFR and TS. The adjusted odds ratio of gastric atrophy for low folate level (≤ 4mg/ml) was 0.21 (95% confidence interval = 0.05-0.78). The associations of tHcy with serum folate and MTHFR genotype were clearly observed in this dataset. The present study demonstrated that folate and MTHFR genotype were the deterministic factors of plasma tHcy, but not H. pylori infection and subsequent gastric atrophy, indicating that even if H. pylori infection influences the risk of atherosclerosis, the influence may not be through the elevation of homocysteine.

show abstract

“…Hyperhomocysteinemia is a well-established independent risk factor for the development of atherosclerosis-related diseases since it causes vascular endothelial damage [45]. Several studies have suggested an association between H. pylori-related atrophic gastritis and hyperhomocysteinemia [27,28,46,47]. Therefore, H. pylori induced hyperhomocysteinemia may be one of the causal mechanisms underlying the reported association between infection and overt atherosclerotic disorders.…”

Section: H Pylori and Ironmentioning

confidence: 95%

Helicobacter pylori Interference with Micronutrients and Orally AdministeredDrugs:ANewMechanism Explaining its Role in Extragastric Disorders

Pietroiusti¹,

Galante²,

Magrini³

et al. 2008

MRMC

View full text Add to dashboard Cite

show abstract

Is There a Possible Relation Between Atrophic Gastritis and Premature Atherosclerosis?

Cited by 12 publications

References 27 publications

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

No associations of Helicobacter pylori infection and gastric atrophy with plasma total homocysteine in Japanese

Helicobacter pylori Interference with Micronutrients and Orally AdministeredDrugs:ANewMechanism Explaining its Role in Extragastric Disorders

Contact Info

Product

Resources

About