Is there a rationale for cortisol-based treatments for PTSD?

Yehuda, Rachel; Golier, Julia A.

doi:10.1586/ern.09.79

Cited by 27 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, low cortisol levels in the immediate aftermath of trauma have been found to predict the development of PTSD (Delahanty, Nugent, Christopher, & Walsh, 2005; Delahanty, Raimonde, & Spoonster, 2000; Yehuda, McFarlane, & Shalev, 1998) as have pre-exposure dysregulations along the glucocorticoid signaling pathway (Van Zuiden, Kavelaars, Geuze, Olff, & Heijnen, 2013). Should the literature support such findings, pharmacologic interventions that regulate cortisol or influence the HPA axis may ultimately be developed as prophylactic measures (Delahanty et al, 2013; Yehuda & Golier, 2009). Indeed, Zohar et al (2011) report a reduced risk for the development of PTSD among patients who received a single, high dose of hydrocortisone within 6 hours of a traumatic event.…”

Section: Biomarkers As Predictors or Risk Factors For Ptsdmentioning

confidence: 99%

Biomarkers of PTSD: military applications and considerations

Lehrner

Yehuda

2014

European Journal of Psychotraumatology

Self Cite

View full text Add to dashboard Cite

BackgroundAlthough there are no established biomarkers for posttraumatic stress disorder (PTSD) as yet, biological investigations of PTSD have made progress identifying the pathophysiology of PTSD. Given the biological and clinical complexity of PTSD, it is increasingly unlikely that a single biomarker of disease will be identified. Rather, investigations will more likely identify different biomarkers that indicate the presence of clinically significant PTSD symptoms, associate with risk for PTSD following trauma exposure, and predict or identify recovery. While there has been much interest in PTSD biomarkers, there has been less discussion of their potential clinical applications, and of the social, legal, and ethical implications of such biomarkers.ObjectiveThis article will discuss possible applications of PTSD biomarkers, including the social, legal, and ethical implications of such biomarkers, with an emphasis on military applications.MethodLiterature on applications of PTSD biomarkers and on potential ethical and legal implications will be reviewed.ResultsBiologically informed research findings hold promise for prevention, assessment, treatment planning, and the development of prophylactic and treatment interventions. As with any biological indicator of disorder, there are potentially positive and negative clinical, social, legal, and ethical consequences of using such biomarkers.ConclusionsPotential clinical applications of PTSD biomarkers hold promise for clinicians, patients, and employers. The search for biomarkers of PTSD should occur in tandem with an interdisciplinary discussion regarding the potential implications of applying biological findings in clinical and employment settings.

show abstract

Section: Biomarkers As Predictors or Risk Factors For Ptsdmentioning

confidence: 99%

Biomarkers of PTSD: military applications and considerations

Lehrner

Yehuda

2014

European Journal of Psychotraumatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Yehuda and Golier (2009) report that it has been hypothesized that individuals who are unable to mount an adequate cortisol response may be slower to terminate the acute stress response when involved in a critical event. The ensuing processes may enhance traumatic recall and sustain activation.…”

Section: Reducing Arousal By Physiological Meansmentioning

confidence: 99%

Early Interventions Following Exposure to Traumatic Events: Implications for Practice From Recent Research

Dyregrov

Regel²

2012

Journal of Loss and Trauma

View full text Add to dashboard Cite

It is has been argued that early interventions for individuals, groups or others affected by traumatic events should not be routinely offered as there is the danger of causing more harm. The notion of ''watchful waiting'' has been espoused in clinical guidelines for the assessment and treatment of posttraumatic stress disorder (PTSD). Instead, a more proactive early intervention is suggested for potentially traumatic events that have the potential to lead to high psychic distress, PTSD, or complicated grief reactions for a significant number of those affected. This involves providing strategies tailored to the needs of these individuals and families and not providing conventional individual therapeutic interventions. Early intervention is wise as recent research has demonstrated that early misconceptions and negative appraisals about one's own reactions to a trauma can be significant in the development and maintenance of posttraumatic reactions and early intervention may help in forming adequate appraisals, thus counteracting misunderstandings and misperceptions. Adopting a ''watchful waiting'' approach with individuals and families has the potential to hinder and impede their longer-term coping responses. Recent advances, especially in the field of memory research, have implications for early interventions. We present recent findings, which make the case for early interventions following exposure to traumatic events.

show abstract

“…Further, G allele carriers evidence higher baseline and post-naloxone cortisol levels, greater peak cortisol response, and greater cortisol area under the curve than participants homozygous for the A allele (31). Acute peritraumatic elevations in cortisol may contain the HPA response and thereby may actually be protective against the development of PTSD (32-34). Thus, as we have proposed elsewhere (35), it is possible that the G allele may protect against the development of PTSD through its potential influence on containment of peritraumatic stress response.…”

mentioning

confidence: 99%

OPRM1 and Diagnosis-Related Posttraumatic Stress Disorder in Binge-Drinking Patients Living with HIV

Nugent

Lally²,

Brown³

et al. 2011

AIDS Behav

View full text Add to dashboard Cite

Posttraumatic stress disorder (PTSD) has been linked to numerous negative outcomes in persons living with HIV (PLH) and there is evidence that PTSD symptoms may play a role in maintaining alcohol use problems. The opioid receptor mu-1 (OPRM1) gene may play a role in both PTSD and alcohol use. We examined the association between PTSD and drinking motives as well as variation in the OPRM1 as a predictor of both PTSD and drinking motives in a sample of 201 PLH reporting recent binge drinking. Self-reported PTSD symptom severity was significantly associated with drinking motives for coping, enhancement, and socialization. OPRM1 variation was associated with decreased PTSD symptom severity as well as enhancement motives for drinking.

show abstract

Is there a rationale for cortisol-based treatments for PTSD?

Cited by 27 publications

References 19 publications

Biomarkers of PTSD: military applications and considerations

Biomarkers of PTSD: military applications and considerations

Early Interventions Following Exposure to Traumatic Events: Implications for Practice From Recent Research

OPRM1 and Diagnosis-Related Posttraumatic Stress Disorder in Binge-Drinking Patients Living with HIV

Contact Info

Product

Resources

About