Is There A Relationship Between Resistin Levels And Left Ventricular End-Diastolic Pressure?

Yıldırım, Özge Turgay; Yı́ldı́rı́r, Aylin; Sade, Leyla Elif; Hasırcı, Senem; Kozan, Hatice; Özçalık, Emre; Okyay, Kaan; Bal, Uğur Abbas; Aydınalp, Alp; Müderrisoğlu, Haldun

doi:10.14744/anatoljcardiol.2018.66181

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Previous studies have revealed that increased serum levels of resistin were associated with the IR, T2DM, AO, and CV diseases (226,227), while there were no significant correlations between resistin levels and echocardiographic parameters including LVEF, Gensini score index, angiographic parameters, and severity of atherosclerosis (228). Both the Framingham Offspring Study and the Health ABC Study have shown that the serum levels of resistin independently corresponded to a high risk of adverse CV outcomes and worsening kidney function among the patients with HF, but adiponectin levels did not (122,123).…”

Section: Resistinmentioning

confidence: 84%

Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus

Berezin

Lichtenauer

2020

Front. Cardiovasc. Med.

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Adipose tissue dysfunction is a predictor for cardiovascular (CV) events and heart failure (HF) in patient population with obesity, metabolic syndrome, and known type 2 diabetes mellitus. Previous preclinical and clinical studies have yielded controversial findings regarding the role of accumulation of adipose tissue various types in CV risk and HF-related clinical outcomes in obese patients. There is evidence for direct impact of infiltration of epicardial adipocytes into the underlying myocardium to induce adverse cardiac remodeling and mediate HF development and atrial fibrillation. Additionally, perivascular adipocytes accumulation is responsible for release of proinflammatory adipocytokines (adiponectin, leptin, resistin), stimulation of oxidative stress, macrophage phenotype switching, and worsening vascular reparation, which all lead to microvascular inflammation, endothelial dysfunction, atherosclerosis acceleration, and finally to increase in CV mortality. However, systemic effects of white and brown adipose tissue can be different, and adipogenesis including browning of adipose tissue and deficiency of anti-inflammatory adipocytokines (visfatin, omentin, zinc-α2-glycoprotein, glypican-4) was frequently associated with adipose triglyceride lipase augmentation, altered glucose homeostasis, resistance to insulin of skeletal muscles, increased cardiomyocyte apoptosis, lowered survival, and weak function of progenitor endothelial cells, which could significantly influence on HF development, as well as end-organ fibrosis and multiple comorbidities. The exact underlying mechanisms for these effects are not fully understood, while they are essential to help develop improved treatment strategies. The aim of the review is to summarize the evidence showing that adipocyte dysfunction may induce the onset of HF and support advance of HF through different biological mechanisms involving inflammation, pericardial, and perivascular adipose tissue accumulation, adverse and electrical cardiac remodeling, and skeletal muscle dysfunction. The unbalancing effects of natriuretic peptides, neprilysin, and components of renin-angiotensin system, as exacerbating cause of altered adipocytokine signaling Berezin et al. Adipocyte Dysfunction in Heart Failure on myocardium and vasculature, in obesity patients at high risk of HF are disputed. The profile of proinflammatory and anti-inflammatory adipocytokines as promising biomarker for HF risk stratification is discussed in the review.

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Section: Resistinmentioning

confidence: 84%

Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus

Berezin

Lichtenauer

2020

Front. Cardiovasc. Med.

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Resistin and Cardiovascular Disease: A Review of the Current Literature Regarding Clinical and Pathological Relationships

Aşkın

Abuş²,

Tanrıverdi

2022

CCR

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: Serum resistin, mainly secreted by the bone marrow, monocytes, and macrophages, contributes to many processes, including endothelial dysfunction, vascular smooth muscle cell (VSMC) proliferation, and atherothrombosis demonstrating effects on the development of hypertension and coronary artery disease (CAD). Previously published clinical studies have shown that plasma resistin levels are significantly associated with cardiovascular disease risk factors and adverse clinical outcomes associated with the condition. Resistin is associated with vascular smooth muscle cell dysfunction in vitro, most plausibly due to its relationship with oxidative stress in advanced atherosclerosis, whereas in vivo studies have shown resistin to be associated with intimal hyperplasia. We aimed to summarize the role of resistin on cardiovascular disease (CVD), as we could not find any review focused on the role of resistin on CVD.

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Euvolemia as a criterion of diuretic therapy efficacy in chronic heart failure: Literature review

Гарганеева

Кужелева

Мареев

2020

SMJ

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Chronic heart failure (CHF) is a typical outcome for all pathological processes affecting the cardiovascular system and is diagnosed in 1–2% of the population in developed countries. The strategy for managing patients with CHF involves the prescription of diuretics for the relief of volume retention syndrome in addition to pathogenetic pharmacotherapy. Considering the confl icting data concerning the effects of diuretics on the long-term prognosis and clinical course of CHF, a strict approach to the analysis of risk/benefit ratio is necessary while choosing a specific diuretic and determining its optimal dose and duration of use. The article reviews state-of-theart literature on the assessment of hydration status in patients with CHF. The euvolemia state, in which the optimal volume of fl uid is achieved in the body of a patient with CHF is viewed from the perspective of evaluating the efficacy and relevance of diuretic therapy.

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Is There A Relationship Between Resistin Levels And Left Ventricular End-Diastolic Pressure?

Cited by 4 publications

References 30 publications

Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus

Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus

Resistin and Cardiovascular Disease: A Review of the Current Literature Regarding Clinical and Pathological Relationships

Euvolemia as a criterion of diuretic therapy efficacy in chronic heart failure: Literature review

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