Is there a role of hypoxemia in penile fibrosis

Melman, Arnold

doi:10.1038/sj.ijir.3900424

Cited by 13 publications

(19 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the field of male sexual function, basic science investigations have expanded the understanding of the physiology and pathophysiology of erectile function and dysfunction, which has led to advances in clinical diagnosis and treatment, in particular of the male genital vascular responses to sexual arousal (Bechara, 2000;Daley et al, 1996;Kim, Vardi, Padma-Nathan, Daley, & Goldstein, 1993;Moreland, 1998;Nehra et al, 1996;Pickard, King, Zar, & Powell, 1994;Sattar, Selpigides, Vanderhaeghen, Schulman, & Wespes, 1995;Tahran, Kuyumcuoglu, & Özgül, 1997). Despite the higher prevalence of female compared to male sexual dysfunction, there are limited investigations concerning the physiology and pathophysiology of the female genital vascular responses to sexual arousal (Berman et al, 2001;Islam et al, 2001).…”

Section: Discussionmentioning

confidence: 98%

Duplex Doppler Ultrasound Assessment of Clitoral Hemodynamics After Topical Administration of Alprostadil in Women with Arousal and Orgasmic Disorders

Bechara

Bertolino

Casabé

et al. 2003

Journal of Sex & Marital Therapy

View full text Add to dashboard Cite

There are limited hemodynamic data in women with arousal or orgasmic disorders and even fewer normative control hemodynamic data in women without sexual dysfunction. In addition, there is limited experience with topical vasoactive agents (used to maximize genital smooth muscle relaxation) applied to the external genitalia during hemodynamic evaluations. The aim of this study was to report duplex Doppler ultrasound clitoral cavernosal arterial changes before and after topical PGE-1 (Alprostadil) administration in control women and in patients with arousal and orgasmic sexual disorders. We found that women with sexual arousal and orgasmic disorders had significantly (p < 0.05) diminished clitoral peak systolic and end diastolic velocity responses compared to controls. Further research is needed to establish the diagnostic role of topical vasoactive agents in the hemodynamic evaluation of women with sexual dysfunction.

show abstract

Section: Discussionmentioning

confidence: 98%

Duplex Doppler Ultrasound Assessment of Clitoral Hemodynamics After Topical Administration of Alprostadil in Women with Arousal and Orgasmic Disorders

Bechara

Bertolino

Casabé

et al. 2003

Journal of Sex & Marital Therapy

View full text Add to dashboard Cite

show abstract

“…These erections have Functional DP receptors in trabecular smooth muscle RB Moreland et al been proposed to be key in the preservation of potency. 33 Thus, PGD 2 may influence erectile function through both local and central mechanisms. Further research is needed to understand the role of DP receptors and PGD synthase in the penis.…”

Section: Discussionmentioning

confidence: 99%

Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle

et al. 2002

View full text Add to dashboard Cite

Prostaglandin D 2 (PGD 2 ) binds to specific G-protein coupled receptors (DP) and induces smooth muscle relaxation by stimulating the synthesis of intracellular cAMP. In this study, we examined the role of PGD 2 and DP receptors in regulating human penile smooth muscle contractility. We determined that human corpus cavernosum tissue and smooth muscle cells in culture expressed functional DP receptor and lipocalin-like prostaglandin D synthase by reverse-transcribed polymerase chain reaction (RT-PCR). Functional PGD synthase activity was confirmed by the synthesis of PGD 2 in human corpus cavernosum smooth muscle cells upon addition of exogenous arachidonic acid. Organ bath preparations of human corpus cavernosum tissue strips, contracted with phenylephrine, relaxed in a dose-dependent fashion to either PGD 2 or the DP selective agonist BW245C. Cultures of human corpus cavernosum smooth muscle cells treated with BW245C showed a two-fold increase in cAMP synthesis. These data are consistent with the expression of functional DP receptors in human corpus cavernosum. This suggests the presence of an intact prostanoid autocrine system that may play a role in regulating penile erectile function.

show abstract

“…The injections were felt to improve cavernous oxygenation and therefore limit hypoxia-induced tissue damage. 39,40 This issue, however, remains controversial.…”

Section: Injection Therapymentioning

confidence: 99%

Medical and surgical advances in the radical prostatectomy patient

Nehra

2000

Int J Impot Res

View full text Add to dashboard Cite

Maintaining the quality of life after surgery in the radical prostatectomy patient is of paramount importance. One of the major dilemmas in surgical management of radical retropubic prostatectomy (RRP) is preservation of the neurovascular bundle and, hence, erectile function and the continence mechanism. This manuscript addresses anatomical considerations for the surgeon and discusses the following issues with regard to medical and surgical therapies: (1) incidence of erectile dysfunction solely due to complications during RRP; (2) nerve damage during RRP; (3) vascular damage during RRP; (4) current medical and surgical therapies for restoring or maintaining potency; and (5) new advances on the horizon for management of the prostatectomy patient.

show abstract

Is there a role of hypoxemia in penile fibrosis

Cited by 13 publications

References 17 publications

Duplex Doppler Ultrasound Assessment of Clitoral Hemodynamics After Topical Administration of Alprostadil in Women with Arousal and Orgasmic Disorders

Duplex Doppler Ultrasound Assessment of Clitoral Hemodynamics After Topical Administration of Alprostadil in Women with Arousal and Orgasmic Disorders

Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle

Medical and surgical advances in the radical prostatectomy patient

Contact Info

Product

Resources

About