Is there an interaction between BDKRB2−9/+9 and GNB3 C825T polymorphisms and elite athletic performance?

Abstract

The -9 deletion allele in the -9/+9 BDKRB2 polymorphism was previously associated with improved endurance performance. We compared the frequency distribution of the BDKRB2 -9/+9 (rs5810761) polymorphism between athletes (n=155) of sports with different demands (endurance runners; n=74 vs. sprinters; n=81) as well as between athletes of different competitive levels (elite level; n=46 vs. national level; n=109). These results were compared to those of 240 non-athletic healthy individuals. We also tested the influence of the interaction between the BDKRB2 -9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. Genotype distribution and allele frequencies were found to be similar in the endurance athlete, sprinter, and control groups (P=0.83 for genotype distribution and P=0.9 for allele frequencies). Similarly, no statistical differences were found between the subgroups of elite-level endurance athletes and national-level endurance athletes, or between elitelevel and national-level sprinters (P>0.09 for all comparisons). There was no interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms in relation to endurance performance (P=0.16 for interaction effect). In conclusion, the BDKRB2 +9/-9 polymorphism is not associated with endurance performance, at least among Israeli athletes, and the GNB3TT+ BDKRB2 -9/-9 "optimal genotype" is not associated with endurance performance.

Bdkrb2 Gene -9/+9 Polymorphism and Swimming Performance

“…In opposition to these findings, the study of Eynon et al [8–10] revealed no correlation between the C825T polymorphism in the gene GNB3 coding for the guanine nucleotide binding protein β-polypeptide 3 and the BDKRB2 -9/+9 polymorphism, despite the fact that the GNB3 C825T polymorphism was previously associated with elite athletic performance.…”

“…The gene has been shown to be associated with higher skeletal muscle metabolic efficiency and with endurance athletic ability [24, 25, 29]. However, its role in determining individual capacity for physical performance has not been clearly established [10, 26]. …”

“…Our findings are in agreement with some previous results. Eynon et al found that allele frequencies and genotype distribution of the BDKRB2 -9/+9 polymorphism were similar both in Israeli Caucasian athletes and the control group [10]. They also revealed no statistical differences between endurance athletes and sprinters, as well as athletes of different competitive levels.…”

Is Gnb3 C825t Polymorphism Associated With Elite Status of Polish Athletes?

“…It is thus very likely that the combined influence of several genetic loci with a significant contribution, complex interaction of multiple genetic polymorphisms (with or without an individual contribution) and/or gene-environment interactions rather than an individual effect of a single polymorphic site have an influence on individual variation of human athletic performance [19–21, 27]. To test the potential interaction of two polymorphisms that have been previously associated with elite athletic performance and their combined influence on athletic status of Israeli elite athletes, Eynon et al [6] investigated the common variation of 9bp-9/ + 9 (rs5810761) of the bradykinin receptor b2 gene ( BDKRB2 ) and the GNB3 C825T polymorphism. The authors, however, observed no association in relation to endurance performance.…”

Current Progress in Sports Genomics

“…Additionally, when divided into tertiles according to their finishing times, the À9/À9 genotype was only overrepresented in the fastest tertile. However, Eynon et al [61] found no significant differences in the frequencies of the À9 allele and À9/À9 genotype between 74 Israeli endurance athletes and 240 controls. The same negative results were obtained by Sawczuk et al [62] and Grenda et al [63] in two studies involving 334 endurance athletes from Russia and Poland.…”