Is Transition Zone Sampling at Repeated Saturation Prostate Biopsy Still Useful

Pepe, Pietro; Candiano, Giuseppe; Fraggetta, Filippo; Galia, Antonio; Grasso, Giuseppe; Aragona, Francesco

doi:10.1159/000320108

Cited by 9 publications

(8 citation statements)

References 60 publications

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“…Meanwhile, the sample from the prostatic transition zone by directed needle biopsies may be omitted due to a lower detection rate compared to TURP. 97,98 Initial therapy in primary localized PCa Initial therapy in primary localized PCa includes radical prostatectomy (RP), hormone therapy (HT), brachytherapy and external-beam radiation therapy (RT).…”

Section: Prostate Cancer (Pca) Epidemiological Characteristicsmentioning

confidence: 99%

An overview of prostate diseases and their characteristics specific to Asian men

Xia¹,

Cui²,

Jiang³

2012

Asian J Androl

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In this paper, we reviewed the features of common prostate diseases, such as benign prostatic hyperplasia (BPH), prostate cancer (PCa) and chronic prostatitis (CP) that are specific to Asian men. Compared to the Westerners, Asians exhibit particular characteristics of prostate diseases. Through summarizing the epidemiology, symptomatology, diagnostics and therapeutics of these diseases, we find that Asians have a lower incidence of PCa than whites, but the incidences of BPH and CP are similar. Asian men with CP often suffer from fewer disease sites, but have a higher frequency of pain during urination rather than after sexual climax. Prostate-specific antigen (PSA) is a widely used marker for the diagnosis of PCa in both Asian and Western countries. Although the PSA level may be lower in Asians, the threshold used is based on whites. After reviewing the treatments available for these diseases, we did not find a fundamental difference between Asians and whites. Furthermore, the selection for the most appropriate treatment based on the individual needs of patients remains a challenge to urologists in Asia. After considering the traits of prostate diseases that are specific to Asian men, we hope to pave the way for the development of specific diagnostic and therapeutic strategies targeted specifically to Asian men.

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Section: Prostate Cancer (Pca) Epidemiological Characteristicsmentioning

confidence: 99%

An overview of prostate diseases and their characteristics specific to Asian men

Xia¹,

Cui²,

Jiang³

2012

Asian J Androl

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“…There has been no general agreement regarding the number of cores and the optimal approach. In addition, we noticed that there was no specific relationship between the method used and the cancer detection rates (4,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) (Table IV).…”

Section: Discussionmentioning

confidence: 99%

Comparison Between a Combined Transrectal and Transperineal Approach and a Transrectal Approach for Prostate Rebiopsy

Shida

Hakariya

Takehara

et al. 2016

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Abstract. Aim: To evaluate whether a combination method involving the transrectal (TR) and transperineal (TP)approach 1, 2, 3, 4 and 5 were 49.2% (551/1,119), 34.7% (75/216), 33.3% (20/60), 26.7% (4/15) Transrectal ultrasound (TRUS)-guided biopsy has been recognized as the standard method for confirming a prostate cancer diagnosis worldwide. The utility of magnetic resonance (MR)-guided biopsy has been indicated in recent reports (1, 2). We agree with the opinion, however, that discussion on TRUS biopsy is still important due to its cost and equipment. In short, we think that MR-guided biopsy is often difficult in developing countries. After the initial introduction of the sextant prostate biopsy technique proposed by Hodge (3), the TRUS-guided biopsy technique has evolved with the introduction of extended 10-to 12-core biopsy and, subsequently, to over 20-core saturation biopsy strategies to minimize the sampling error and improve the accuracy of prostate cancer detection (4). However, it is well-recognized that even the standard 12-core TRUS-guided biopsy can miss up to 30% of cancers (5). TRUS-guided biopsy predominantly targets the lateral and posterior peripheral gland and can miss anteriorly located cancers. Therefore, several studies have focused on methods for anterior and apical biopsies.Transperineal (TP) biopsy of the prostate is an alternative approach that is less frequently performed. Kakehi et al. (6) reviewed 212,065 biopsies carried out at 548 institutions during the period between 2004 and 2006 in Japan. Of the 212,065 biopsies, 76% were carried out using the transrectal (TR) approach, 23% using the TP approach and only 1% using the combined methods of TR and TP (TR+TP). Ong et al. (7) reported that TP biopsy accounted for <0.5% of all prostate biopsies performed in Australia in 2007. However, there has been increasing interest in TP biopsy in recent 4685This article is freely accessible online.

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“…Some studies have reported that even low-risk PCA may demonstrate disease upgrading or upstaging. 5 , 6 Even known indicators of the severity of PCA, such as prostate-specific antigen (PSA) kinetics or initial biopsy results at the time of PCA diagnosis, do not reliably predict adverse pathology when men are monitored by AS. 7 Therefore, imaging techniques have played an increasingly important role in the management of localized PCA.…”

Section: Introductionmentioning

confidence: 99%

Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer

Lee

Koo

Lee

et al. 2015

Prostate International

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PurposeTo determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA).MethodsWe retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4%) exhibited non visible tumors on MRI of clinical stage T1c. The imaging results were compared with the pathological findings with respect to both stage and Gleason scores (GS).ResultsOf the 177 prostatectomy patients with non visible tumors on MRI, pathological findings resulted in the upgrading of 49(27.7%) patients to a sum of GS 7 or more. 101(57.1%) patients exhibited tumor volumes greater than 0.5cc. The biochemical recurrence rate was significantly higher in the pathological upgraded group compared with the nonupgraded group after a mean follow-up time of 29 months. In the multiple logistic analysis, non visible tumor on MRI was not a significant predictor of low-risk PCA.ConclusionsEven though cancer foci were not visualized by postbiopsy MRI, the pathological tumor volumes and extent of GS upgrading were relatively high. Therefore, nonvisible tumors by multiparametric MRI do not appear to be predictive of low-risk PCA.

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Is Transition Zone Sampling at Repeated Saturation Prostate Biopsy Still Useful

Cited by 9 publications

References 60 publications

An overview of prostate diseases and their characteristics specific to Asian men

An overview of prostate diseases and their characteristics specific to Asian men

Comparison Between a Combined Transrectal and Transperineal Approach and a Transrectal Approach for Prostate Rebiopsy

Nonvisible tumors on multiparametric magnetic resonance imaging does not predict low-risk prostate cancer

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