Is Varicella Zoster Virus an Etiologic Factor in Kawasaki Disease? A Case Report and Review of the Literature

MIS-C patients who were reinfected with SARS-CoV-2. Report of 2 cases

“…KD and its recurrences have an unknown etiology, but it is theorized some microbial pathogens (including coronavirus) can trigger immune dysregulation causing KD in genetically susceptible children. 8,9 Recurrence of KD usually occurs within 2 years of the first episode. The presence of coronary artery aneurysm, initial resistance to IVIG therapy, longer duration of fever, male sex, young age, lower hemoglobin levels, and high AST levels in the first episode carries a risk for future recurrence.…”

Reinfección por SARS-CoV-2 en pacientes con antecedentes de MIS-C. Presentación de dos casos

“…Se desconoce la etiología de la EK y su recurrencia, pero se cree que algunos microrganismos patógenos (incluidos los coronavirus) pueden desencadenar una desregulación inmunitaria que provoque la EK en niños genéticamente susceptibles. 8,9 La recurrencia de la EK suele producirse a los…”

Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease

“…In addition to EBV, certain KD patients also have concomitant varicella zoster virus or coxsackievirus A4 infection ( Turkay et al, 2006 ; Toprak et al, 2015 ). Given that the features of HHV6-infected patients resemble those symptoms observed in KD children ( Kakisaka et al, 2012 ; Alramadhan et al, 2020 ), HHV-6B was thus suggested to be a critical mediator during the pathogenesis of KD, and HHV-6B infection was also suggested to be responsible for the increased number of KD patients during the SARS-CoV-2 pandemic ( Dursun and Temiz, 2020 ).…”