1990
DOI: 10.1016/0006-291x(90)90636-2
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Islet amyloid polypeptide (IAPP;Amylin) influences the endocrine but not the exocrine rat pancreas

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Cited by 61 publications
(35 citation statements)
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“…Recent studies showed that IAPP and pramlintide suppress postprandial glucagon secretion (25,26). Indeed, we found greater suppression of postprandial glucagon in type 1 diabetic patients when pramlintide was given.…”
supporting
confidence: 48%
“…Recent studies showed that IAPP and pramlintide suppress postprandial glucagon secretion (25,26). Indeed, we found greater suppression of postprandial glucagon in type 1 diabetic patients when pramlintide was given.…”
supporting
confidence: 48%
“…Those cyclic nucleotide phosphodiesterase inhibitors were successfully used in previous studies by Fehmann et al to demonstrate CGRP-stimulated amylase secretion from guinea pig pancreatic acini (1990). The absence of these agents in the present study cannot account for the negative action of IAPP, because our preliminary study showed that even in high concentrations (10-10-10-5 M) IAPP had no effect on basal amylase release as was shown by physiological doses (Fehmann et al 1990). …”
Section: Resultsmentioning
confidence: 51%
“…However, investigation of IAPP's action on pancreatic exocrine function has scarcely begun. The only report noted has shown that physiological doses of IAPP (10-11-10-9 M) has no effect on amylase release from isolated rat pancreatic acini (Fehmann et al 1990). Our present data confirmed this result and further extended the findings to shown that even at pharmacological doses, IAPP has no significant effect on amylase release caused by various stimulants.…”
Section: Resultsmentioning
confidence: 96%
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“…In the present studies amylin did not inhibit glucose-induced insulin secretion, but on the contrary appeared to stimulate it at the higher dose used. It is possible that a portal infusion of amylin produces a pancreatic response more similar to that seen in perfused pancreas preparations where amylin causes either no effect [29] or a stimulation [30] of insulin secretion.…”
Section: Discussionmentioning
confidence: 98%