Isolated Abdominal Wall Metastasis of Endometrial Carcinoma

Luz, Rita; Leal, Rui Filipe Monteiro; Simões, Jorge; Gonçalves, Matilde; Matos, Isabel

doi:10.1155/2014/505403

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…Although the pathophysiology is not fully understood, distant metastasis in any solid tumor is traditionally considered to be related to lymphatic and hematogenous dissemination. Therefore, the anterior abdominal wall, with an abundant arterial supply, anastomotic venous network, and lymphatic system that drains cranially and caudally to several lymphatic chains, including pelvic and para-aortic lymph nodes, provides a favorable condition for metastases[ 11 ]. Other mechanisms have been postulated, including direct extension and spread through embryonic remnants[ 5 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the anterior abdominal wall, with an abundant arterial supply, anastomotic venous network, and lymphatic system that drains cranially and caudally to several lymphatic chains, including pelvic and para-aortic lymph nodes, provides a favorable condition for metastases[ 11 ]. Other mechanisms have been postulated, including direct extension and spread through embryonic remnants[ 5 , 12 ]. Moreover, when the metastases are connected to the surgical incision, whether the surgical approach is laparotomy or laparoscopy, one of the potential explanations may be that tumor cells penetrate the uterine wall or the fallopian tube to disseminate intraperitoneally to the recent trauma, and hypothesis is that malignant cells spill through the cervical os during hysterectomy and implant directly in the incision[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…First, a comprehensive examination is necessary for patients with abdominal wall recurrence to rule out other metastases. An enlarged excision can be performed if there is no distant disease[ 11 ]. The surgical procedure consists of an enlarged excision of the tumor and reconstruction of the abdominal wall.…”

Section: Discussionmentioning

confidence: 99%

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Plastic surgery for giant metastatic endometrioid adenocarcinoma in the abdominal wall: A case report and review of literature

Wang¹,

Wang²,

Liang³

et al. 2022

WJCC

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BACKGROUND Endometrial cancer (EC) is a common gynecological malignancy, but metastasis to the abdominal wall is extremely rare. Therefore, an appropriate treatment approach for large metastatic lesions with infection remains a great challenge. CASE SUMMARY We report the case of a 65-year-old woman who developed abdominal metastasis of endometrioid adenocarcinoma, as defined by International Obstetrics and Gynecology stage II, in which the lesion was complicated by infection. A right hemicolectomy was performed for colon metastasis in relation to her initial gynecological cancer 3 years ago. When admitted to our department, a complete resection of the giant abdominal wall lesion was performed, and a Bard composite mesh was used to reconstruct the abdominal wall. A local flap was used to close the resultant large defect in the external covering of the abdomen. The patient underwent chemotherapy following cytoreductive surgery. Pathology revealed metastasis of EC, and molecular subtyping showed copy number high of TP53 mutation, implying a poor prognosis. CONCLUSION When EC patients develop giant abdominal wall metastasis, a plastic surgeon should be included before contemplating resection of tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Plastic surgery for giant metastatic endometrioid adenocarcinoma in the abdominal wall: A case report and review of literature

Wang¹,

Wang²,

Liang³

et al. 2022

WJCC

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“…Las localizaciones típicas de recurrencia son: cúpula vaginal, nódulos linfáticos pélvicos y para aórticos; y a distancia los mas comunes son ovarios, peritoneo y pulmones 12 . Se han descrito otras localizaciones consideradas atípicas, tales como nódulos extra abdominales (supraclaviculares, axilares y mediastinales), hígado, bazo, glándulas adrenales, esqueleto axial y sistema nervioso central 12 , en menor frecuencia se han identificado recurrencias en colón e intestino delgado 18 , así como en pared abdominal 19 .…”

Section: Discussionunclassified

Reporte de caso: Metástasis gástrica de carcinoma endometrial, una localización inusual

Rueda-Espinel

Rueda-Perea

Orostegui-Correa

2020

Rev. chil. obstet. ginecol.

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Introduction: the endometrial carcinoma is the sixth cancer worldwide. Usually it is diagnosed in early stages. The sites of recurrence includes vaginal cuff and lymph nodes, however some metastasis have been described to vagina, peritoneum and lungs, among others. Case report: Elder female with history of an endometrial carcinoma 7 years ago, surgically treated. With histopathology that reported myometrial infiltration in a 95% without invasion to other organs and lymphadenectomy free of neoplasm (FIGO IB), who consult at the emergency room due to abdominal pain and black stool, with further studies that make evident a gastric lesion with biopsy reported as a poorly differentiated carcinoma, vimentin positive, compatible with gastric metastasis secondary to an endometrial carcinoma. Chemoterapy was indicated, documenting total posterior response of the lesion. Discussion: Secondary lessions in stomach are rare. If they are present at the moment of diagnosis half of the patients concomitantly have metastasis in other organs. The endometrial carcinoma hasn't been described as a common localization that result in this compromise. Conclusion: the case exposed is a clinical challenge, a therapeutic success is shared. Limited evidence is available. Further studies are necessary to evaluate the prognosis, therapeutic options and to define the relevance of screening tests for early detection.

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“…In the present case, the metastasis appeared late; more than 4 years after surgical resection. Luz et al 9 reported a case of an isolated abdominal wall metastasis after vaginal rather than abdominal hysterectomy for EC just over 6 months after surgery. She underwent surgical excision, and the defect was repaired using a synthetic mesh as in this case.…”

Section: Discussionmentioning

confidence: 99%

Late metastatic endometrial carcinoma at the repair site of an abdominal wall incisional hernia

Meshikhes

Albadr

Sulais

et al. 2017

SMJ

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The abdominal wall is a very rare site for endometrial cancer metastases. Its appearance generally indicates advanced cancer with poor prognosis. We report a case of a 55-year-old female who presented with an incisional hernia 4 years after abdominal panhysterectomy for endometrioid adenocarcinoma in 2009. Open hernia mesh repair was performed but on follow-up, she complained of pain and a swelling at the repair site. This was radiologically diagnosed as fibromatosis, but tru-cut biopsy confirmed presence of fibromatosis as well as a metastatic endometrial carcinoma. She was started on neoadjuvant chemotherapy, but had poor response, and therefore, radical excision was performed. She remained well with no metastatic recurrence at 12-month follow-up. This case illustrates late appearance of abdominal wall metastasis from abdomino-pelvic malignancies and highlights the need to exclude the presence of recurrence or metastases prior to surgical repair of incisional hernia occurring after the resection of abdominal or pelvic malignancy.

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Isolated Abdominal Wall Metastasis of Endometrial Carcinoma

Cited by 5 publications

References 24 publications

Plastic surgery for giant metastatic endometrioid adenocarcinoma in the abdominal wall: A case report and review of literature

Plastic surgery for giant metastatic endometrioid adenocarcinoma in the abdominal wall: A case report and review of literature

Reporte de caso: Metástasis gástrica de carcinoma endometrial, una localización inusual

Late metastatic endometrial carcinoma at the repair site of an abdominal wall incisional hernia

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