Isolated Non-16/18 High-Risk Human Papillomavirus Cervical Infection: Re-Evaluation After One Year

Abstract

Introduction: High-risk human papillomavirus cervical infection is currently a well-established cause of cervical cancer. However, only a few women with persistent infections will develop cervical precancerous and malignant lesions. Approximately 20% of all cervical cancers are attributable to non-16/18 serotypes. This study aims to evaluate the results of our clinical approach to women with this infection.Material and Methods: We conducted an observational and prospective study from September 2012 to September 2017, which included women with isolated non-16/18 high-risk human papillomavirus infection (with normal cytology). After re-evaluation, two groups were compared: women with spontaneous regression of the infection and women with persistent infection. Clinical and demographic data were analysed as well as the rate of progression to precancerous and malignant lesions.Results: We included 165 women, of which 121 were re-evaluated with co-test at least one year later. After re-evaluation, 13.2% of women revealed precancerous lesions but only two (1.7%) of them presented high-grade squamous intraepithelial lesions. Sixty-seven women (55.4%) showed spontaneous regression of the infection and 54 women (44.6%) maintained it. Women with persistent infection developed more precancerous lesions (27.8%; p < 0.001) and high-grade squamous intraepithelial lesions (3.7%; p < 0.001). There was also an association between persistent infection and postmenopausal status.Discussion: Human papillomavirus 16/18 cervical infection is associated with higher risk of cervical cancer when compared with other serotypes.Conclusion: Re-evaluation with co-test one year after the diagnosis of isolated non-16/18 human papillomavirus infection seems to be a reasonable approach.

Risks for cervical abnormalities in women with non‐16/18 high‐risk human papillomavirus infections in south Shanghai, China

“…In LSIL cases, non‐16/18 single and multiple HPV infections accounted for 66.78%, implying a higher risk of disease than HPV16/18. Therefore, the pathogenic risk of non‐16/18 HPV infection in samples from this region was significantly higher than the United States and European countries 26,27 . The top four most frequently infected HPV in HSIL (or SCC) patients were HPV16, HPV52, HPV18, HPV58.…”

“…Therefore, the pathogenic risk of non-16/18 HPV infection in samples from this region was significantly higher than the United States and European countries. 26,27 The top four most frequently infected HPV in HSIL (or SCC) patients were HPV16, HPV52, HPV18, HPV58. HPV52 and HPV58 were common in these patients.…”

The meaning of high‐risk HPV other than type 16/18 in women with negative cytology: Is it really safe to wait for 1 year?

“…Vargas et al re‐evaluated 121 non‐16/18 hrHPV positive/cytology negative patients with co‐test at least one year later. After re‐evaluation, 13.2% of women revealed precancerous lesions and 2 (1.7%) of them presented high‐grade squamous intraepithelial lesions 25 …”

Male papillomavirus infection and genotyping in the Qingyuan area

“…The high-risk subtypes of HPV play an important role in the development of penis cancer [ 11 ]. Infection with multiple HPV subtypes would increase the risk of abnormal proliferation and canceration of infected cells [ 14 – 16 ]. Therefore, it is necessary to reduce the risk of carcinogenesis of infected tissues by increasing the frequency of follow-ups, performing regular pathological examinations for pathological tissues, or strengthening the treatment for high-risk HPV-infected subjects and multiple HPV subtypes (including high-risk subtypes) [ 17 ].…”