Isolation and Anti-Fatty Liver Activity of a Novel Cerebroside from the Sea CucumberAcaudina molpadioides

The anti-tumor activities of cerebrosides derived from sea cucumber <i>Acaudina molpadioides</i> and starfish <i>Asterias amurensis in vitro</i> and <i>in vivo</i>

“…AMC were prepared and analyzed using the procedure described by Xu et al 6 . The preparation of AMC and AAC solution was followed by the liposome preparation done by Z. Hossain et al 25 , and diluted to the desired concentrations by medium before use.…”

“…Except a few species that inhabit in brackish water, starfi sh are bascially benthic organisms found in all oceans. There are over 1,500 known Cerebrosides are one of the simplest lipid classes of glycosphingolipids and consist of monosaccharides such as glucose and galactose , an amide-linked fatty acid and sphingoid base which is also called long-chain base 6 . Cerebrosides have been shown to display variety of biological activities such as anti-tumor, immunomodulatory, and antimicrobial activities 7 10 .…”

The Protective Effects of Cerebrosides from Sea Cucumber and Starfish on the Oxidative Damage in PC12 Cells

“…Compared with other sources, the contents of cerebrosides in marine organisms are lower, but due to the marine special ecological environment, cerebrosides in marine organisms have novel structures and stronger bioactivity 14 . The glycosphingolipids of marine invertebrates, including sea cucumber and starfish, have unique sphingoid bases with a conjugated diene 19 .…”

“…It is one of the simplest lipid classes of glycosphingolipids and consists of monosaccharides, an amide-linked fatty acid and sphingoid base which is also called long-chain base 14 . Cerebroside has been…”

Isolation of cytotoxic glucoerebrosides and long-chain bases from sea cucumber Cucumaria frondosa using high speed counter-current chromatography

“…The EtOAc/n-BuOH phase was concentrated in vacuo to yield a residue, which was washed with cold acetone to produce an acetone-insoluble fraction less polar lipid fraction . The less polar lipid fraction was volatilized to dryness, which are crude cerebrosides of sea cucumber Cucumaria frondosa 48.2 g , and then frozen at 20 for isolation by HSCCC 23 .…”