ISOLATION AND CHARACTERIZATION OF Β-Sitosterol FROM ELAEAGNUS ANGUSTIFOLIA CULTIVATED IN IRAQ

Zeez, Rand A; Abaas, Ibrahim S.; Kadhim, Enas Jawad

doi:10.22159/ajpcr.2018.v11i11.29030

Cited by 14 publications

(10 citation statements)

References 9 publications

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“…In addition to presence of benzoic compounds such as vanillic acid in EALE, 12 there is some reports which are shown that senjed leaves contain flavonoids, alkaloids, steroids, terpenoids, as well as betasitosterol. 9 Previous studies shown that vanillic acid could decrease the insulin resistance and the hyperglycemia effectively. 22,23 Also, there are some reports which are indicate that the most of flavonoids have potent alpha-glucosidase inhibitory property and anti-hyperglycemic effect, as well as improving glucose tolerance.…”

Section: Discussionmentioning

confidence: 99%

“…8 Senjed leaves contains most useful constituents such as flavonoids, alkaloids, steroids, terpenoids, as well as beta-sitosterol. 9 It has been shown that flavonoids and phenolic compounds of senjed leaves are greater than its flower, especially in methanolic and ethanolic extracts. 10 Studies have been shown that senjed fruit polysaccharide could decrease the blood glucose and lipids in diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats

Sadat¹,

Alami²,

Mousavi³

2020

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Introduction: Diabetes mellitus is a metabolic disorder, which affects many people throughout the world. The inefficacy and multiple side effects of most synthetic anti-diabetic drugs are reported by various studies. Thus, many researchers are focused on the use of medicinal plants as safe and potent anti-hyperglycemic drugs. The aim of this study is the evaluation of the effect of Afghan senjed (Elaeagnus Angustifolia L.) leaves aqueous alcoholic extract on blood glucose level of diabetic rats. Methods: Rats were divided into 6 groups: normal, diabetic, metformin and Elaeagnus Angustifolia leaves extract (EALE) groups, which received 200, 400 and 800 mg/kg doses of extract for 15 days. Diabetes was induced by single dose intraperitoneal administration of streptozotocin (STZ). During treatment, the effect of single and repeated oral administration of EALE on blood glucose level of diabetic rats was evaluated. On last day, the effect of EALE on oral glucose tolerance test (OGTT) was also assessed. Results: All doses of EALE showed significant reduction in blood glucose level, an improvement of glucose tolerance and enhancement in body weight. Conclusion: EALE possessed an antihyperglycemic property in diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats

Sadat¹,

Alami²,

Mousavi³

2020

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“…Phytosterols (PS) are biologically active steroidal compounds obtained from plant foods and cholesterol is found in animals [1,2]. Beta-sitosterol, campesterol, and stigmasterol are the common phytosterols in plant and animal diet such as edible oils, nuts, cereals and citrus fruits [3,4]. These steroids have a common cholesterol skeleton with different side chains.…”

Section: Introductionmentioning

confidence: 99%

Bioavailability Problems of Phytosterols: A Systematic Review

DUDEKULA

KUMAR²,

RANGANAYAKULU³

2022

Int J App Pharm

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Phytosterols (PS) are biologically active steroidal compounds obtained from plant foods and cholesterol is found in animals. They have a prominent role in reducing the low-density lipoprotein (LDL) cholesterol levels, thus decreasing the risk of many diseases. PSs also have anti-cancer, antioxidant, antiulcer, immunomodulatory, antibacterial, antifungal effects and modulate inflammation by promoting the wound healing and inhibition of platelet aggregation. The most challenging part concerned about phytosterols was bioavailability. Phytosterol’s absorption and the concentration of circulation over the body were lesser in human intestine compared to cholesterol because of its selectivity and return through intestinal transporters. We searched PubMed, Scopus, Embase, Google scholar and major conference proceedings. Sixteen such therapeutically potent plant steroids were studied in this systematic review to assess the bioavailability issues of phytosterols. Swiss ADME web tool that gives free access to a pool of fast yet robust predictive models for physicochemical properties, pharmacokinetics, drug-likeness and medicinal chemistry friendliness was used for the study.

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“…E. Angustifolia leaves contain most useful constituents such as flavonoids, alkaloids, steroids, terpenoids, as well as beta-sitosterol (15). It has been shown that the amount of flavonoids in E. Angustifolia leaves is more than its flower (16).…”

Section: Introductionmentioning

confidence: 99%

Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous Extract on Memory of Male Rats

Alami¹,

Haidari²,

Ebrahimi³

et al. 2021

IJAM

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This study is aimed to evaluate the effect of Elaeagnus Angustifolia leaves extract (EALE) on the memory of male rats. Rats were divided into 7 groups: 4 groups in the first stage (Control, EALE 100, 200 and 400 mg/kg) to determine the effective-dose of EALE on memory; and 3 groups in the second stage (Normal, Scopolamine and EALE effective-dose) to evaluate the effect of EALE on scopolamine-induced memory impairment. Rats received EALE by i.p. administration for 14 days and the memory function of all groups was evaluated by the Y-maze test on days 8 and 15. Only scopolamine and effective dose of EALE groups were received scopolamine 30 min before Y-maze test. The total cholesterol and triglyceride levels of stage 2 rats were also measured. On day 8, the percentage of spontaneous alternation (%SA) was significantly increased in EALE 400 mg/kg group, as compared with the control group. On day 15, there was a significant difference in %SA only between EALE 100 mg/kg group and the control group. The %SA was significantly increased in the EALE effective-dose group only on day 15, as compared with scopolamine group (P<0.05). The effective-dose of EALE was also significantly decreased the total cholesterol (P<0.01) and triglyceride (P<0.001) levels in comparison with scopolamine group. In conclusion, a high dose of EALE only in a short-term administration period and its low dose in a long-term administration period had memory-enhancing effects. The low dose of EALE as an effective-dose of EALE could reverse the scopolamine-induced memory impairment.

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ISOLATION AND CHARACTERIZATION OF Β-Sitosterol FROM ELAEAGNUS ANGUSTIFOLIA CULTIVATED IN IRAQ

Cited by 14 publications

References 9 publications

Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats

Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats

Bioavailability Problems of Phytosterols: A Systematic Review

Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous Extract on Memory of Male Rats

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